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(antihemophilic factor)
25,536 results
  • The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus. [Journal Article]
    PLoS Genet 2019; 15(9):e1008379Misslinger M, Scheven MT, … Haas H
  • Efficient adaptation to iron starvation is an essential virulence determinant of the most common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the cytosolic monothiol glutaredoxin GrxD plays an essential role in iron sensing in this fungus. Our studies revealed that (i) GrxD is essential for growth; (ii) expression of the encoding gene, grxD, is repressed by the transcript…
  • Clinical pattern of hemophilia and causes of variability. [Journal Article]
    Blood Coagul Fibrinolysis 2019; 30(1S Suppl 1):S4-S6Mingot-Castellano ME
  • : In persons with hemophilia, the severity and spontaneity of bleeding episodes depends on the degree of factor deficiency present in the patients. Severe hemophilia is classically characterized by a factor VIII (FVIII) or factor IX (FIX) coagulant activity below 1% of normal (spontaneous and severe bleeds). Moderate hemophilia is associated with factor activity between 1 and 5% of normal (milder…
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