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Unbound Medicine.
(antilymphocyte globulin)
12,996 results
  • Optimum timing of antithymocyte globulin in relation to adoptive regulatory T cell therapy. [Journal Article]
    Am J Transplant. 2023 Jan; 23(1):84-92.Muckenhuber M, Mucha J, … Wekerle T
  • Reducing the recipient's T cell repertoire is considered to increase the efficacy of regulatory T cell (Treg) therapy. This necessitates timing the administration of antithymocyte globulin (ATG) early enough before adoptive cell therapy (ACT) so that residual serum ATG does not deplete the transferred Tregs. The optimum time point in this regard has not been defined. Herein, we report the effects…
  • Controversies and expectations for the prevention of GVHD: A biological and clinical perspective. [Review]
    Front Immunol. 2022; 13:1057694.Watkins B, Williams KM
  • Severe acute and chronic graft versus host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation. Historically, cord blood and matched sibling transplantation has been associated with the lowest rates of GVHD. Newer methods have modified the lymphocyte components to minimize alloimmunity, including: anti-thymocyte globulin, post-transp…
  • B-Cell Reconstitution After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis. [Journal Article]
    Neurol Neuroimmunol Neuroinflamm. 2022 11; 9(6)von Niederhäusern V, Ruder J, … Trück J
  • Autologous hematopoietic stem cell transplantation (aHSCT) is increasingly used to treat aggressive forms of multiple sclerosis (MS). This procedure is believed to result in an immune reset and restoration of a self-tolerant immune system. Immune reconstitution has been extensively studied for T cells, but only to a limited extent for B cells. As increasing evidence suggests an important role of …
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