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623 results
  • LEISHMANICIDAL ACTIVITY in vivo OF A MILTEFOSINE DERIVATIVE IN Mesocricetus auratus. [Journal Article]
    Acta Trop. 2020 May 24; 209:105539.da Silva JC, Nunes JB, … Marques MJ
  • Visceral leishmaniasis (VL) is a chronic and systemic disease; if untreated, it can cause death in a large number of cases. The therapy is based on the use of antimonials, which have been used for over 50 years. However, cases of resistance have been reported in some countries. In this context, miltefosine (MIL) was introduced to treat antimonial unresponsive cases. Nonetheless, in recent years M…
  • MRPA-independent mechanisms of antimony resistance in Leishmania infantum. [Journal Article]
    Int J Parasitol Drugs Drug Resist. 2020 Apr 02; 13:28-37.Douanne N, Wagner V, … Fernandez-Prada C
  • Control of both human and canine leishmaniasis is based on a very short list of chemotherapeutic agents, headed by antimonial derivatives (Sb). The utility of these molecules is severely threatened by high rates of drug resistance. The ABC transporter MRPA is one of the few key Sb resistance proteins described to date, whose role in detoxification has been thoroughly studied in Leishmania parasit…
  • A spotlight on the diagnostic methods of a fatal disease Visceral Leishmaniasis. [Review]
    Parasite Immunol. 2020 May 07 [Online ahead of print]Kumar A, Pandey SC, Samant M
  • Leishmania donovani (a causative agent of visceral leishmaniasis) poses a serious health threat to the human population which is fatal if left untreated. The life cycle of Leishmania alternates between vertebrate host and Phlebotomine fly as intermediate ones. Due to the difficulties linked to vector (sandfly) control and the lack of an effective vaccine, the control of leishmaniasis relies mostl…
  • Safety profile of meglumine antimoniate intralesional infiltration for cutaneous leishmaniasis. [Journal Article]
    Expert Rev Anti Infect Ther. 2020 Apr; 18(4):381-387.Fernandes HJ, da Silva RE, … Cota G
  • Objectives: Cutaneous leishmaniasis is a neglected disease, associated with high morbidity, which is partially due to the toxicity of available therapies. The pentavalent antimonial derivatives intralesional infiltration has proven to be as effective as the intravenous drug-based therapy, however, there is a lack of robust safety data.Methods: Phase II, uncontrolled, unicenter clinical trial to a…
  • Evaluation of antileishmanial drugs activities in an ex vivo model of leishmaniasis. [Journal Article]
    Parasitol Int. 2019 Aug; 71:163-166.Terreros MJS, de Luna LAV, Giorgio S
  • Leishmaniasis is a poverty-related disease, the chemotherapy of which is based on few drugs. The in vitro macrophage-amastigote model using mouse peritoneal cells, human-monocyte transformed macrophages and immortalized cell lines have been used to test new and safe antileishmanial drugs. Considering the differences for drug sensitivities between these Leishmania infected cells, the efficacy of a…
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