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Unbound Medicine.
(antimycotic)
2,611 results
  • Natural antioxidant pterostilbene as an effective antibiofilm agent, particularly for gram-positive cocci. [Journal Article]
    World J Microbiol Biotechnol. 2020 Jul 01; 36(7):101.Vaňková E, Paldrychová M, … Masák J
  • Pterostilbene (PTE), a dimethylated analogue of resveratrol, mostly contained in Vitis vinifera leaves or in other plant sources is well-known for its antioxidant activity. Due to its bioavailability, low hydrophilicity and thus ability to penetrate hydrophobic biological membranes it was found to be an antimicrobial agent. These properties of PTE offer the possibility of its use in the treatment…
  • Rhizoferrin Glycosylation in Rhizopus microsporus. [Journal Article]
    J Fungi (Basel). 2020 Jun 18; 6(2)Škríba A, Patil RH, … Havlíček V
  • Rhizopus spp. are the most common etiological agents of mucormycosis, causing over 90% mortality in disseminated infections. The diagnosis relies on histopathology, culture, and/or polymerase chain reaction. For the first time, the glycosylation of rhizoferrin (RHF) was described in a Rhizopus microsporus clinical isolate by liquid chromatography and accurate tandem mass spectrometry. The ferment…
  • Phase I Study in Healthy Women of a Novel Antimycotic Vaginal Ovule Combining Econazole and Benzydamine. [Journal Article]
    Infect Dis Obstet Gynecol. 2020; 2020:7201840.Di Stefano AFD, Radicioni MM, … Comandini A
  • CONCLUSIONS: The tested fixed-dose combination showed a good safety profile consistently with the known tolerability of both active substances. In addition, the confirmed low bioavailability of the drugs excludes the possibility of any accumulation effects and limits the risk of undesired systemic effects. This trial is registered at ClinicalTrials.gov with the identifier NCT02720783 last updated on 07 February 2017.
  • Review on Current Status of Echinocandins Use. [Review]
    Antibiotics (Basel). 2020 May 02; 9(5)Mroczyńska M, Brillowska-Dąbrowska A
  • Fungal infections are rising all over the world every year. There are only five medical compound classes for treatment: triazoles, echinocandins, polyenes, flucytosine and allylamine. Currently, echinocandins are the most important compounds, because of their wide activity spectrum and much lower sides effects that may occur during therapy with other drugs. Echinocandins are secondary metabolites…
  • Invasive Rhino-Orbito-Cerebral Mucormycosis in Pediatric Patient with Acute Leukemia. [Journal Article]
    Klin Onkol. 2020 Spring; 33(2):138-144.Bačová E, Chovanec F, … Kolenová A
  • CONCLUSIONS: Mucormycosis is an invasive fungal infection with high morbidity and mortality. Early diagnosis and initiation of effective therapy using a combination of amphotericin B administration and surgery are necessary to obtain a favorable outcome. The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.
  • Ozonized Gel Against Four Candida Species: A Pilot Study and Clinical Perspectives. [Journal Article]
    Materials (Basel). 2020 Apr 08; 13(7)Monzillo V, Lallitto F, … Colombo M
  • Ozone therapy can display a wide range of clinical beneficial effects, including antimicrobial, immune-stimulant, analgesic, anti-hypoxic actions. However, there is still a paucity of data regarding the ozone fungicide activity. Oral Candida is the most common fungal infection in the mouth among denture wearers and people with weakened immune systems. In the case of generalized candidiasis or imm…
  • Vulvar pruritus-Causes, Diagnosis and Therapeutic Approach. [Review]
    Dtsch Arztebl Int. 2020 02 21; 116(8):126-133.Woelber L, Prieske K, … Jaeger A
  • CONCLUSIONS: As vulvar pruritus has multiple causes, standard- ization of its diagnostic evaluation and treatment would be l efficacy and to meet the diverse needs of women who suffer from this condition.
  • Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent. [Journal Article]
    Acta Pharm Sin B. 2020 Mar; 10(3):434-446.Feng H, Hu L, … Zhang H
  • Ischemic stroke is a severe disorder resulting from acute cerebral thrombosis. Here we demonstrated that post-ischemic treatment with ciclopirox olamine (CPX), a potent antifungal clinical drug, alleviated brain infarction, neurological deficits and brain edema in a classic rat model of ischemic stroke. Single dose post-ischemic administration of CPX provided a long-lasting neuroprotective effect…
  • [Bilateral periocular necrotizing fasciitis with unilateral orbital involvement]. [Journal Article]
    Ophthalmologe. 2020 Mar 04 [Online ahead of print]Heichel J, Griebsch M, … Viestenz A
  • The case of an 82-year-old woman with bilateral necrotizing fasciitis and unilateral orbital involvement is presented. A mixed infection consisting of Streptococcus pyogenes, Staphylococcus aureus, and Aspergillus fumigatus could be verified. The latter was detected by molecular pathological investigations. Treatment consisted of repeated surgical debridement in combination with systemic broad-sp…
  • [Scedosporium apiospermum-a rare pathogen of keratomycosis]. [Journal Article]
    Ophthalmologe. 2020 Mar 03 [Online ahead of print]Lenk J, Raiskup F, … Röβler S
  • This article presents the case of a 44-year-old contact lens wearer who presented with acute keratitis resistant to antibacterial treatment in the right eye. The anterior segment of the eye showed circular conjunctival hyperemia, a corneal white cell infiltrate with radiating margins and a central corneal erosion. Microbiological investigation of a corneal scraping revealed growth of Scedosporium…
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