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214 results
  • Effects of Achyranthes bidentata alcohol on proliferation capacity of osteoblasts and miRNA in Runx2. [Journal Article]
    Exp Ther Med. 2019 Sep; 18(3):1545-1550.Hua S, Zhang X
  • Achyranthes bidentata is a herbal plant commonly used in the treatment of osteoporosis and bone nonunion with traditional Chinese medicine. Achyranthes bidentata alcohol is a major component extracted from Achyranthes bidentata, which has been proved to be able to exert a variety of pharmacological effects, such as anti-inflammation, antipyresis, anti-rheumatism, diuresis and anti-osteoporosis. T…
  • A novel pH-controlled hydrogen sulfide donor protects gastric mucosa from aspirin-induced injury. [Journal Article]
    J Cell Mol Med. 2017 10; 21(10):2441-2451.Yang CT, Lai ZZ, … Zhang H
  • Hydrogen sulphide (H2 S) serves as a vital gastric mucosal defence under acid condition. Non-steroidal anti-inflammatory drugs (NSAIDs) are among widely prescribed medications with effects of antipyresis, analgesia and anti-inflammation. However, their inappropriate use causes gastric lesions and endogenous H2 S deficiency. In this work, we reported the roles of a novel pH-controlled H2 S donor (…
  • Anti-allergic effect of Artemisia extract in rats. [Journal Article]
    Exp Ther Med. 2016 Aug; 12(2):1130-1134.Deng Y, Liu Z, Geng Y
  • Artemisia apiacea (also known as Artemisia annua L) is a herb commonly used in traditional Chinese medicine. In the early 1970s, artemisinin was isolated and identified as the active antimalarial ingredient, and thereafter, A. apiacea and artemisinin have been studied extensively, such as anti-inflammation and antipyresis, antibacteria, antiparasitic and immunosuppression effects of A. apiacea ex…
  • Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria. [Randomized Controlled Trial]
    Malar J. 2016 Apr 27; 15:244.Wattanakul T, Teerapong P, … Tarning J
  • CONCLUSIONS: Paracetamol plasma concentrations after oral syrup and intramuscular administration in patients with acute falciparum malaria were described successfully by a two-compartment disposition model. Relative oral bioavailability compared to intramuscular dosing was estimated as 84.4 % (95 % CI 68.2-95.1 %). Dosing simulations showed that a loading dose followed by six-hourly dosing intervals reduced the time delay to reach therapeutic drug levels after both routes of administration. The safety and efficacy of loading dose paracetamol antipyretic regimens now needs to be established in larger studies.
  • The Effect of Antipyretic Temperature Reduction on Heart Rate in Febrile Infants: a Pilot Study. [Journal Article]
    Am J Ther. 2017 Sep/Oct; 24(5):e540-e543.Mitelpunkt A, Heitner S, … Glatstein M
  • It is generally accepted that fever is associated with tachycardia and that the relationship, of an approximate increase of 10 beats/minute per °Celsius rise in temperature, is particularly pronounced in infants. It would be useful to determine how closely pulse and fever are associated during pharmacological temperature reduction, and whether it is influenced by the infectious status of the infa…
  • Are Recommended Doses of Acetaminophen Effective for Children Aged 2 to 3 Years? A Pharmacokinetic Modeling Answer. [Journal Article]
    Pediatr Emerg Care. 2016 Jan; 32(1):6-8.Abourbih DA, Gosselin S, … Kazim S
  • CONCLUSIONS: With the use of this model, the 10 mg/kg dose does not reach the plasma concentration value for antipyresis (10-20 μg/mL), whereas 15 mg/kg is adequate only if assuming a greater absorption constant. The 160 mg dose is effective only for children weighing 10.9 kg. Individual differences in drug bioavailability, volume of distribution, and absorption/elimination constants undoubtedly exist, and future studies directly measuring plasma APAP concentration and pharmacokinetics are needed. However, these results indicate that dosages for APAP in children should be weight based and manufacturers should review their dosing recommendations.
  • Fever and antipyresis in infection. [Journal Article]
    Med J Aust. 2011 Oct 17; 195(8):458-9.Young PJ, Saxena MK, Beasley RW
  • Fever is an important mechanism of intrinsic resistance against infectious disease. A variety of studies point to a potential detrimental effect of temperature lowering in infectious disorders, but high-quality evidence from randomised controlled trials is lacking. In ambulatory care settings, we need to know whether antipyretics influence the severity and duration of illnesses and, in critically…
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