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27,295 results
  • [Drug Repositioning for Alzheimer's Disease]. [Journal Article]
    Brain Nerve 2019; 71(9):961-970Ihara M, Saito S
  • To date, all clinical trials of disease-modifying drugs for Alzheimer's disease (AD) have been unsuccessful, making investments into AD drug development very risky despite the high unmet need. Drug repositioning or repurposing approaches are relatively less expensive and more promising compared to novel drug development in AD. About 40% of clinical trials for AD currently in progress across the w…
  • Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease. [Randomized Controlled Trial]
    N Engl J Med 2019; 381(12):1103-1113Yasuda S, Kaikita K, … AFIRE Investigators
  • CONCLUSIONS: As antithrombotic therapy, rivaroxaban monotherapy was noninferior to combination therapy for efficacy and superior for safety in patients with atrial fibrillation and stable coronary artery disease. (Funded by the Japan Cardiovascular Research Foundation; AFIRE UMIN Clinical Trials Registry number, UMIN000016612; and ClinicalTrials.gov number, NCT02642419.).
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