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1,226 results
  • Potential therapeutic effect of NK1R antagonist in diabetic non-healing wound and depression. [Journal Article]
    Front Endocrinol (Lausanne). 2022; 13:1077514.Li M, Ma H, … Min P
  • Diabetes is a global disease with huge impacts on patients due to its complications, among which non-healing wounds and depression are common and challenging. The neurokinin 1 receptor (NK1R) inhibitor, aprepitant has been broadly applied for an antidepressant effect in depressive patients. Recent literature has indicated a therapeutic effect of downregulation in NK1R to diabetes-related fracture…
  • Histamine skin prick tests: from established diagnostic technique to advanced experimental biomarker. [Journal Article]
    Skin Pharmacol Physiol. 2023 Jan 09 [Online ahead of print]Bamps D, Berdon K, … Luven KU
  • Introduction Skin prick tests have a long history as diagnostic and pharmacodynamic biomarker. Besides visual assessments of the wheal and flare, objective blood flow measurements using laser Doppler imaging (LDI) and laser speckle contrast imaging (LSCI) have been reported. In light of these advancements, an up-to-date characterization of the histamine-evoked response is worthwhile. Methods A si…
  • Improving Nursing Knowledge and Patient Education about Aprepitant's Effects on Hormonal Contraception: A Performance Improvement Project. [Journal Article]
    J Perianesth Nurs. 2023 Jan 02 [Online ahead of print]David AC, Pereira K, … Funk E
  • CONCLUSIONS: The findings suggest that providing a standardized presentation about aprepitant may improve the PACU nurses' ability to verbalize key information about aprepitant, including the need for patients to use a secondary form of birth control. This increase in nursing knowledge and confidence, along with improved written discharge instructions, may have led to improved patient comprehension of aprepitant discharge education. Additionally, there was an increase in the percentage of patients who were able to recall the need to use a secondary form birth control for 28 days, to reduce the likelihood of an unintentional pregnancy.
  • Novel inhibitors of breast cancer resistance protein (BCRP, ABCG2) among marketed drugs. [Journal Article]
    Eur J Pharm Sci. 2023 Feb 01; 181:106362.Deng F, Sjöstedt N, … Kidron H
  • Drug-drug interactions (DDIs) are a major concern for the safe use of medications. Breast cancer resistance protein (BCRP) is a clinically relevant ATP-binding cassette (ABC) transporter for drug disposition. Inhibition of BCRP increases the plasma concentrations of BCRP substrate drugs, which potentially could lead to adverse drug reactions. The aim of the present study was to identify BCRP inhi…
  • Cisplatin and AKI: an ongoing battle with new perspectives-a narrative review. [Review]
    Int Urol Nephrol. 2022 Dec 12 [Online ahead of print]Volovat S, Apetrii M, … Hogas S
  • Acute kidney injury (AKI) is a growing global health problem with increased mortality and morbidity. Cisplatin is achemotherapy drug first introduced in 1978, and since then, it became one of the most widely used and successful anti-cancer medication. However, there are risks associated with cisplatin administration, such as nephrotoxicity. Mechanisms of nephrotoxicity include proximal tubular in…
  • Cisplatin-Induced Nausea and Vomiting: Effect of Herbal Medicines. [Review]
    Plants (Basel). 2022 Dec 06; 11(23)Shin Y, Kim B, Kim W
  • Cisplatin is a chemotherapeutic agent that is widely used to treat various types of cancers. However, its side effects, most commonly nausea and vomiting, limit its widespread use. Although various drugs, such as ondansetron and aprepitant, are used to alleviate these side effects, their efficacy is still debated. This review aims to summarize the results of 14 studies on the effects of seven sin…
  • Preparation and Characterization of Aprepitant Solid Dispersion with HPMCAS-LF. [Journal Article]
    ACS Omega. 2022 Nov 08; 7(44):39907-39912.Liu J, Li Y, … Li S
  • This study focused on improving the physicochemical characteristics of aprepitant with poor water solubility by preparing solid dispersion (SD). To prepare the SD with HPMCAS-LF, the solvent evaporation method was applied. Based on dissolution analysis, the dissolution rate of SD increased by five times compared with aprepitant. In addition, scanning electron microscopy (SEM), X-ray powder diffra…
  • Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection. [Journal Article]
    Viruses. 2022 Oct 31; 14(11)McAuley AJ, Jansen van Vuren P, … Vasan SS
  • The repurposing of licenced drugs for use against COVID-19 is one of the most rapid ways to develop new and alternative therapeutic options to manage the ongoing pandemic. Given circa 7817 licenced compounds available from Compounds Australia that can be screened, this paper demonstrates the utility of commercially available ex vivo/3D airway and alveolar tissue models. These models are a closer …
  • Current understanding of the etiology of cyclic vomiting syndrome and therapeutic strategies in its management. [Review]
    Expert Rev Clin Pharmacol. 2022 Nov; 15(11):1305-1316.Frazier R, Venkatesan T
  • Cyclic vomiting syndrome (CVS) is a chronic-debilitating disorder of the gut-brain interaction and is characterized by recurrent episodes of nausea and vomiting.Recent studies indicate that it is common and affects 2% of the US population. Unfortunately, there is significant heterogeneity in the management of these patients in the medical community. This review article aims to bridge this gap and…
  • Fabrication of an aprepitant nanosuspension using hydroxypropyl chitosan to increase the bioavailability. [Journal Article]
    Biochem Biophys Res Commun. 2022 Nov 26; 631:72-77.Liu J, Li S, … Bai M
  • Aprepitant has been classified into BCS class IV, which has low permeability and poor water solubility, resulting in low bioavailability. This study focused on improving its permeability and solubility in order to improve the oral bioavailability of aprepitant. Hydroxypropyl chitosan (HPCS) was used as a stabilizer for the nanosuspension and wet milling was utilized for improving aprepitant's bio…
  • StatPearls: Aprepitant [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)RitchieMichael K.MKWest Virginia UniversityKohliArpanAWest Virginia UniversityBOOK
  • Aprepitant is a medication used in the management and treatment of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). It is in the neurokinin-1 antagonist class of medications. This activity outlines and reviews the indications, action, and contraindications for aprepitant as a valuable agent in the prevention and management of CINV and PONV. This activi…
  • Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth. [Journal Article]
    ACS Chem Neurosci. 2022 09 07; 13(17):2646-2657.Nathan Kochen N, Vasandani V, … Sachs JN
  • Recent high-resolution structures of alpha-synuclein (aSyn) fibrils offer promise for rational approaches to drug discovery for Parkinson's disease and Lewy body dementia. Harnessing the first such structures, we previously used molecular dynamics and free energy calculations to suggest that threonines 72 and 75─which line water-filled cavities within the fibril stacks─may be of central importanc…
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