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8,322 results
  • Aprotinin does not Impair Vascular Function in Patients Undergoing Coronary Artery Bypass Graft Surgery. [Journal Article]
    Horm Metab Res. 2023 Jan; 55(1):65-74.Tolkmitt J, Brendel H, … Morawietz H
  • Bleeding is a major complication in coronary artery bypass graft surgery. Antifibrinolytic agents like serine protease inhibitor aprotinin can decrease postoperative bleeding and complications of cardiac surgery. However, the effects of aprotinin on vascular function are not completely elucidated. We compared the ex vivo vascular function of left internal mammary arteries from patients undergoing…
  • Protein 3D Hydration: A Case of Bovine Pancreatic Trypsin Inhibitor. [Journal Article]
    Int J Mol Sci. 2022 Nov 26; 23(23)Kruchinin SE, Kislinskaya EE, … Fedotova MV
  • Characterization of the hydrated state of a protein is crucial for understanding its structural stability and function. In the present study, we have investigated the 3D hydration structure of the protein BPTI (bovine pancreatic trypsin inhibitor) by molecular dynamics (MD) and the integral equation method in the three-dimensional reference interaction site model (3D-RISM) approach. Both methods …
  • Lung injury following cardiopulmonary bypass: a clinical update. [Review]
    Expert Rev Cardiovasc Ther. 2022 Nov; 20(11):871-880.Nteliopoulos G, Nikolakopoulou Z, … Dimarakis I
  • Cardiopulmonary bypass (CPB) is an integral component of cardiac surgery; however, one of its most critical complications is acute lung injury induced by multiple factors including systemic inflammatory response.
  • Characterizing Metastable States with the Help of Machine Learning. [Journal Article]
    J Chem Theory Comput. 2022 Sep 13; 18(9):5195-5202.Novelli P, Bonati L, … Parrinello M
  • Present-day atomistic simulations generate long trajectories of ever more complex systems. Analyzing these data, discovering metastable states, and uncovering their nature are becoming increasingly challenging. In this paper, we first use the variational approach to conformation dynamics to discover the slowest dynamical modes of the simulations. This allows the different metastable states of the…
  • Methodological considerations for ghrelin isoforms assay in clinical evaluation in anorexia nervosa. [Journal Article]
    Compr Psychoneuroendocrinol. 2022 Aug; 11:100140.Tezenas du Montcel C, Duriez P, … Tolle V
  • The growing interest concerning the role of metabolic sensors in various eating disorders requires the implementation of a strict methodology to collect, store and process blood samples in clinical studies. In particular, measurement of isoforms of the appetite-stimulating hormone, ghrelin, has been challenging in clinical settings. Indeed the acyl ghrelin (AG) isoform is rapidly degraded into de…
  • Rodent models to study sodium retention in experimental nephrotic syndrome. [Review]
    Acta Physiol (Oxf). 2022 07; 235(3):e13844.Xiao M, Bohnert BN, … Artunc F
  • Sodium retention and edema are hallmarks of nephrotic syndrome (NS). Different experimental rodent models have been established for simulating NS, however, not all of them feature sodium retention which requires proteinuria to exceed a certain threshold. In rats, puromycin aminonucleoside nephrosis (PAN) is a classic NS model introduced in 1955 that was adopted as doxorubicin-induced nephropathy …
  • Rapid Rational Design of Cyclic Peptides Mimicking Protein-Protein Interfaces. [Journal Article]
    Methods Mol Biol. 2022; 2405:231-244.Santini BL, Zacharias M
  • The cPEPmatch approach is a rapid computational methodology for the rational design of cyclic peptides to target desired regions of protein-protein interfaces. The method selects cyclic peptides that structurally match backbone structures of short segments at a protein-protein interface. In a second step, the cyclic peptides act as templates for designed binders by adapting the amino acid side ch…
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