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173 results
  • Vasopressin & Oxytocin In Control Of The Cardiovascular System: An Updated Review. [Journal Article]
    Curr Neuropharmacol 2019Japundžić-Žigon N, Lozić M, … Murphy D
  • Since the discovery of vasopressin (VP) and oxytocin (OT) in 1953, considerable knowledge has been gathered about their roles in cardiovascular homeostasis. Unraveling VP vasoconstrictor properties and V1a receptors in blood vessels generated powerful hemostatic drugs and drugs effective in the treatment of certain forms of circulatory collapse (shock). Recognition of the key role of VP in water …
  • quareticctivity of S olidago canadensiscultivated ingypt and etermination of theostioactiveraction. [Journal Article]
    Iran J Pharm Res 2019; 18(2):922-937Abdel Baki PM, El-Sherei MM, … Ibrahim Abdallah HM
  • Despite the traditional use of Solidago canadensis L. (Asteraceae) as a diuretic drug, there is a scarcity in scientific data concerning the activity of its different extracts and fractions as well as the class of constituents responsible for this diuretic action. A comparative study was carried out for the diuretic activities of the different standardized extracts and fractions of the flowering …
  • Tolvaptan use in children and adolescents with autosomal dominant polycystic kidney disease: rationale and design of a two-part, randomized, double-blind, placebo-controlled trial. [Journal Article]
    Eur J Pediatr 2019; 178(7):1013-1021Schaefer F, Mekahli D, … Shoaf SE
  • CONCLUSIONS: This will be the first clinical study to evaluate tolvaptan in pediatric ADPKD. What is Known: • Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder causing the development of cysts that impede kidney function over time and eventually induce renal failure • There are few data on the effects of tolvaptan, the only treatment approved for adults to slow disease progression, in pediatric ADPKD patients with early-stage disease What is New: • A phase 3, placebo-controlled study is evaluating tolvaptan over 3 years in children and adolescents with ADPKD • This study is designed to account for challenges of tolvaptan dosing and outcome assessment specific to the pediatric population.
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