- Target-based drug repurposing against Candida albicans-A computational modeling, docking, and molecular dynamic simulations study. [Journal Article]J Cell Biochem. 2022 02; 123(2):289-305.JC
- The emergence of multidrug-resistant strains of Candida albicans has become a global threat mostly due to co-infection with immune-compromised patients leading to invasive candidiasis. The life-threatening form of the disease can be managed quickly and effectively by drug repurposing. Thus, the study used in silico approaches to evaluate Food and Drug Administration (FDA) approved drugs against t…
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- Factors Influencing Non-cardiac Side Effects of Dipyridamole When Used for Myocardial Perfusion Stress Testing. [Journal Article]J Med Imaging Radiat Sci. 2012 Mar; 43(1):43-51.JM
- CONCLUSIONS: Side effects of dipyridamole are generally known, but the factors influencing incidence and severity are not. This study has shown that patient demographic information normally gathered before MPI procedures can help determine the frequency and severity of some side effects. Providing more accurate information to a patient on the possible side effects could help reduce patient anxiety and improve patient cooperation.
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- A co-module approach for elucidating drug-disease associations and revealing their molecular basis. [Journal Article]
- Understanding how drugs and diseases are associated in the molecular level is of critical importance to unveil disease mechanisms and treatments. Until recently, few studies attempt end to discover important gene modules shared by both drugs and diseases.
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- Asymmetric hydrogenation of alpha-primary and secondary amino ketones: efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine. [Journal Article]
- Two beta-receptor agonists (-)-denopamine and (-)-arbutamine were prepared in good yields and enantioselectivities by asymmetric hydrogenation of unprotected amino ketones for the first time by using Rh catalysts bearing electron-donating phosphine ligands. A series of alpha-primary and secondary amino ketones were synthesized and hydrogenated to produce various 1,2-amino alcohols in good yields …
- Sonovue improves endocardial border detection and variability in assessing wall motion score and ejection fraction during stress echocardiography. [Clinical Trial, Phase III]
- CONCLUSIONS: Sonovue significantly improved EBD and reduced intra-observer variability of EF at rest and during peak arbutamine infusion.
- [Comparison of usefulness of dobutamine-atropine and dobutamine-adenosine stress echocardiography in detection of coronary artery disease]. [Journal Article]Pol Merkur Lekarski. 2004 Apr; 16(94):313-5.PM
- Stress echocardiography is valuable, non-invasive method useful for detection of coronary artery disease. In stress echocardiography myocardial ischemia is most commonly induced by exercise or pharmacological agents like dobutamine, dypiridamole, arbutamine or adenosine. The aim of the study was to compare usefulness of dobutamine-atropine stress echocardiography (DATR) with dobutamine-adenosine …
- Use of pharmaceuticals in noninvasive cardiovascular diagnosis. [Review]Heart Dis. 2002 Sep-Oct; 4(5):315-30.HD
- A number of pharmaceuticals are employed as diagnostic agents for cardiovascular diseases. Four groups of agents are reviewed here: 1) vasoactive substances employed as adjuncts to physical maneuvers in diagnosis of structural heart disease; 2) vasodilators used to produce heterogeneity of coronary flow; 3) sympathomimetic agents simulating the effects of exercise on the heart for the purpose of …
- Effect of ligand structure on the zinc-catalyzed Henry reaction. Asymmetric syntheses of (-)-denopamine and (-)-arbutamine. [Journal Article]
- [reaction: see text] Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the beta-receptor agonists (-)-denopamine and (-)-arbutamine.
- Pharmacologic interventions in nuclear radiology: indications, imaging protocols, and clinical results. [Review]
- Nuclear radiology is valuable in assessing pathophysiology of a variety of organ systems. Pharmacologic interventions are often employed in radionuclide imaging to monitor the physiologic changes, which in turn facilitate the diagnosis. Metoclopramide, erythromycin, and cisapride have been used for gastric emptying studies. To overcome false-negative results, cimetidine, pentagastrin, and glucago…
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- Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. [Journal Article]
- CONCLUSIONS: In the presence of coronary stenoses that abolished regional flow reserve, myocardial uptake of MIBI, compared with (201)Tl, significantly underestimated the arbutamine-induced flow heterogeneity. The attenuation of MIBI uptake and diminished defect contrast during arbutamine stress were comparable with those previously reported for dobutamine stress.
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- Identification of viable myocardium early after acute myocardial infarction using closed-loop arbutamine echocardiography: comparison with positron emission tomography. [Journal Article]Acta Cardiol. 2001 Dec; 56(6):387-94.AC
- CONCLUSIONS: Low-dose arbutamine stress testing is safe early after AMI. Contractile reserve can be rapidly identified by echocardiography and is specific, but moderately sensitive for predicting reversible dysfunction.
- Pharmacological stress agents for evaluation of ischemic heart disease. [Review]
- Ischemic heart disease is the leading cause of death in the developed countries for those older than 65 years of age. In patients suspected to have coronary artery disease a stress test should be performed to identify the vulnerability of the myocardium to ischemia. As a rule of thumb, the evaluation of coronary artery disease is best done by exercise stress test. In patients who are not able to …
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- Assessment of adenosine, arbutamine and dobutamine as pharmacological stress agents during (99m)Tc-tetrofosmin SPECT imaging: a randomized study. [Randomized Controlled Trial]Nucl Med Commun. 2001 Dec; 22(12):1305-11.NM
- We evaluated the use of adenosine, dobutamine and arbutamine with (99m)Tc-tetrofosmin myocardial perfusion imaging. Forty patients under investigation for suspected coronary artery disease were recruited. Each had a resting scan and two separate stress scans on different days, in a randomized cross-over study. Resultant images were blindly reported in 13 segments per scan as normal, reversible or…
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- Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing: a comparison with clinical and perfusion variables. [Journal Article]
- CONCLUSIONS: For hard cardiac events, RNA ejection fraction provides prognostic information besides that provided by clinical and myocardial perfusion imaging. In patients who cannot exercise and are undergoing noninvasive evaluation with pharmacologic stress testing and myocardial perfusion imaging, ejection fraction should be measured simultaneously for risk assessment optimization.
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- Advances in Pharmacological Cardiac Stress Testing: Arbutamine Closed-Loop Feedback System. [Journal Article]
- In less than a decade, the use of stress echocardiography has grown dramatically, with both exercise and, for patients unable to exercise adequately, pharmacological stressors, such as dobutamine. A new pharmacological stress agent, arbutamine, administered using a closed-loop computerized feedback system, has recently received approval by the Food and Drug Administration for use with echocardiog…
- Arbutamine stimulation detects viable myocardium 4 weeks after coronary occlusion. [Journal Article]J Am Soc Echocardiogr. 2001 Feb; 14(2):138-48.JA
- At low doses, dobutamine has potent inotropic, but limited chronotropic, effects-properties that may be necessary for detection of hibernating myocardium. The efficacy of other catecholamines, which have more closely coupled inotropic and chronotropic effects, for the detection of viable myocardium is unknown. This study evaluated the efficacy of arbutamine, a catecholamine with potent chrono-tro…
- Diagnostic efficacy of SonoVue. [Review]
- SonoVue is a second-generation ultrasound contrast agent consisting of phospholipid-stabilized microbubbles filled with sulfur hexafluoride, with outstanding stability and resistance to pressure. The efficacy of SonoVue (0.5, 1, 2, 4 mL) was compared with Albunex (doses 0.08 and 0.22 mL/kg) in patients with suspected ischemic disease and suboptimal endocardial-border delineation on unenhanced ech…
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- [Stress echocardiography]. [Review]Z Kardiol. 2000; 89 Suppl 1:78-85.ZK
- Within the last decade of this millennium, stress echocardiography has been established for the diagnosis and follow-up of coronary artery disease. The basis is the technical development of the echo machines: first, the improved echocardiographic resolution and, second, the digital image storage of a whole cineloop, which may be interpreted frame-by-frame in an ECG synchronized manner for several…
- Changes of QT dispersion in patients with coronary artery disease dependent on different methods of stress induction. [Journal Article]
- CONCLUSIONS: Patients with CAD can be identified on the basis of QTd under stress. These changes were not as marked in patients with MI as their rest values were already increased. Overall, drug-induced stress produced greater differences than dynamic exercise, suggesting that the ischemic threshold might be lower in the former.
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- Comparative physiological study of arbutamine with exercise in humans. [Controlled Clinical Trial]Clin Sci (Lond). 2000 Apr; 98(4):489-94.CS
- Pharmacological stress testing may be used in the diagnosis of coronary artery disease when there are contra-indications to the use of conventional exercise protocols. The responses to such testing using arbutamine and to conventional treadmill exercise were compared in eight patients. Respiratory gas analysis and cardiovascular observations were performed during both tests. For an equivalent inc…
- Pharmacological stress testing. [Review]
- Pharmacological stress in conjunction with radionuclide myocardial perfusion imaging has become a widely used noninvasive method of assessing patients with known or suspected coronary artery disease. In the United States, over one third of perfusion imaging studies are performed with pharmacological stress. Pharmacological stress agents fall into two categories: coronary vasodilating agents such …
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- Spatial distribution of QT dispersion measured by magnetocardiography under stress in coronary artery disease. [Journal Article]
- This study investigated changes in spatial distribution of QT duration in patients with and without coronary artery disease (CAD) using magnetocardiography. Thirty-six-channel magnetocardiograms (MCGs) were registered at rest and under stress in 15 patients with chest pain, seven of whom had significant coronary stenosis. QT dispersion (QTd) was calculated for MCG and 12-lead electrocardiogram (E…
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- Pharmacologic stress echocardiography. Dobutamine and arbutamine stress testing. [Review]
- Pharmacologic stress testing is an important noninvasive method for evaluating patients with known or suspected coronary artery disease who are unable to adequately exercise. Pharmacologic stress echocardiography using dobutamine has been developed over the last 10 to 15 years as an alternative to vasodilator stress testing using nuclear perfusion imaging. As experience has grown, digital subtrac…
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- Combined Tc-99m sestamibi first-pass radionuclide angiography and cardiac SPECT imaging during arbutamine infusion delivered by a computerized closed-loop system. [Journal Article]Clin Nucl Med. 1999 Jan; 24(1):42-7.CN
- CONCLUSIONS: Simultaneous cardiac radionuclide angiography and SPECT imaging are feasible during arbutamine infusion. This potent beta agonist increases cardiac output through a chronotropic effect with no significant changes in EDV. The discordance in SPECT and radionuclide angiography results may represent incremental diagnostic and prognostic information provided by both studies.
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- [Cardiology in 1997]. [Journal Article]Cas Lek Cesk. 1998 Oct 05; 137(19):585-9.CL
- A review of the most important findings published during 1997 in cardiovascular papers is presented: Chlamydia pneumoniae was recognised as a potential risk factor for coronary artery disease (CAD) and possible pathogenic agent for valvular aortic stenosis. Valvular changes similar to the valvular disease reported after ergotamine and methylsergide were also detected in obese women treated with a…
- Effect of atenolol or metoprolol on arbutamine stress echocardiography in patients suspected of having coronary artery disease. [Clinical Trial]Am J Cardiol. 1998 Sep 15; 82(6):830-2, A10.AJ
- Arbutamine stress echocardiography was performed in 81 patients with suspected coronary artery disease. Arbutamine infusion, using a dedicated closed-loop delivery device, provided comparable myocardial stress in patients receiving beta-1 blockers versus those who were not.
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- Hemodynamic effects of arbutamine. [Journal Article]Am J Cardiol. 1998 Sep 01; 82(5):699-702, A9.AJ
- This study examined the hemodynamic effects of arbutamine, a synthetic catecholamine, in 12 patients with and 7 patients without coronary artery disease. Arbutamine produced a balanced positive inotropic (increase in left ventricular dp/dt) and chronotropic effect (increase in heart rate).
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- A comparison of adenosine and arbutamine for myocardial perfusion imaging. [Journal Article]Eur J Nucl Med. 1998 Apr; 25(4):394-400.EJ
- We have compared our standard stress protocol (adenosine combined with exercise) with the new stress agent arbutamine, for thallium-201 myocardial perfusion imaging (MPI) in order to assess the comparative value of arbutamine. We studied 23 patients referred for MPI, and each patient had two studies (18 males, median age 66 years, five with previous myocardial infarction). Uptake scores were assi…