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(arsenic trioxide)
3,736 results
  • Ceritinib-Induced Regression of an Insulin-Like Growth Factor-Driven Neuroepithelial Brain Tumor. [Journal Article]
    Int J Mol Sci 2019; 20(17)Russo A, Paret C, … Faber J
  • The insulin-like growth factor (IGF) pathway plays an important role in several brain tumor entities. However, the lack of inhibitors crossing the blood-brain barrier remains a significant obstacle for clinical translation. Here, we targeted the IGF pathway using ceritinib, an off-target inhibitor of the IGF1 receptor (IGF1R) and insulin receptor (INSR), in a pediatric patient with an unclassifie…
  • Arsenic trioxide inhibits angiogenesis in vitro and in vivo by upregulating FoxO3a. [Journal Article]
    Toxicol Lett 2019; 315:1-8Sun Z, Li M, … Wu Y
  • Arsenic trioxide (As2O3) has been used clinically for the treatment of acute promyelocytic leukemia and some solid tumors. However, the mechanisms of its anti-tumor effects are still elusive. Angiogenesis is a key process for tumor initiation, and increasing evidence has supported the role of anti-angiogenesis caused by arsenic in tumor suppression, although the detailed mechanism is not well und…
  • Synergy between arsenic trioxide and JQ1 on autophagy in pancreatic cancer. [Journal Article]
    Oncogene 2019Xu C, Wang X, … Zhang J
  • Pancreatic cancer is a deadliest type of malignancy and lacks effective intervention. We here report a potential strategy for treatment of this malignancy by the combination of arsenic trioxide (ATO) and BET bromodomain inhibitor JQ1. These two agents synergistically modulate multistages of autophagy and thus induce apoptosis effectively in pancreatic cancer cells. Our genomic and biochemical dat…
  • Differentiation syndrome in acute promyelocytic leukaemia. [Review]
    Br J Haematol 2019Stahl M, Tallman MS
  • Acute promyelocytic leukaemia differentiation syndrome (APL DS) is seen when patients with APL are treated with all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO). Presenting symptoms are varied but frequently include dyspnoea, unexplained fever, weight gain >5 kg, unexplained hypotension, acute renal failure and a chest radiograph demonstrating pulmonary infiltrates or pleural or peric…
  • The SUMO Pathway in Hematomalignancies and Their Response to Therapies. [Review]
    Int J Mol Sci 2019; 20(16)Boulanger M, Paolillo R, … Bossis G
  • SUMO (Small Ubiquitin-related MOdifier) is a post-translational modifier of the ubiquitin family controlling the function and fate of thousands of proteins. SUMOylation is deregulated in various hematological malignancies, where it participates in both tumorigenesis and cancer cell response to therapies. This is the case for Acute Promyelocytic Leukemias (APL) where SUMOylation, and subsequent de…
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