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Unbound Medicine.
(arsenic trioxide)
4,421 results
  • Arsenic Trioxide-Induced Mandibular Osteomyelitis Associated with Mycotic Infestation: A Case Report. [Case Reports]
    J Maxillofac Oral Surg. 2023 Mar; 22(1):146-149.Mrad S, Menhall A, … Bassil J
  • Arsenic trioxide used in endodontic treatments has been shown to cause severe damages to surrounding bone and periodontal tissues. This report describes a case of alveolar osteomyelitis triggered by arsenic trioxide pulp devitalization and associated with mycotic infestation. Following clinical and radiological examinations, the concerned tooth was extracted, bone sequestrum was removed and granu…
  • Acute Promyelocytic Leukemia with Rare Genetic Aberrations: A Report of Three Cases. [Case Reports]
    Genes (Basel). 2022 Dec 23; 14(1)Liu G, Liu L, … Li X
  • Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) that is characterized by the PML::RARA fusion or, more rarely, a variant RARA translocation. While APL can be clinically suspected, diagnosis of APL requires genetic confirmation. Targeted therapy such as all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has dramatically improved the prognosis of APL pa…
  • Bio-fabricated nanodrugs with chemo-immunotherapy to inhibit glioma proliferation and recurrence. [Journal Article]
    J Control Release. 2023 Jan 20; 354:572-587.Wang R, Zhang X, … Di L
  • Glioblastoma multiforme (GBM) is the most malignant brain tumor with high mortality. Knowledge of the stemness concept has developed recently, giving rising to a novel hallmark with therapeutic potential that can help in management of GBM recurrence and prognosis. However, limited blood-brain barrier (BBB) penetration, non-discriminatory distribution, and deficiency of diagnosis remain three majo…
  • Metabolic and genetic derangement: a review of mechanisms involved in arsenic and lead toxicity and genotoxicity. [Review]
    Arh Hig Rada Toksikol. 2022 Dec 01; 73(4):244-255.Sadiku OO, Rodríguez-Seijo A
  • Urbanisation and industrialisation are on the rise all over the world. Environmental contaminants such as potentially toxic elements (PTEs) are directly linked with both phenomena. Two PTEs that raise greatest concern are arsenic (As) and lead (Pb) as soil and drinking water contaminants, whether they are naturally occurring or the consequence of human activities. Both elements are potential carc…
  • Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America. [Review]
    Hematology. 2023 Dec; 28(1):2158015.Gómez-De León A, Demichelis-Gómez R, … Rego EM
  • CONCLUSIONS: Disparities in access to technologies, supportive care capacity, and availability of novel agents and HSCT hinder results in our region, reflecting barriers common to other LMICs. Recent developments in the diagnosis and treatment of this disease must be implemented through education, collaborative clinical research, and advocacy to improve outcomes.
  • In silico mechanisms of arsenic trioxide-induced cardiotoxicity. [Journal Article]
    Front Physiol. 2022; 13:1004605.Li Y, Wan R, … Zhang H
  • It has been found that arsenic trioxide (ATO) is effective in treating acute promyelocytic leukemia (APL). However, long QT syndrome was reported in patients receiving therapy using ATO, which even led to sudden cardiac death. The underlying mechanisms of ATO-induced cardiotoxicity have been investigated in some biological experiments, showing that ATO affects human ether-à-go-go-related gene (hE…
  • Sodium arsenite and dimethylarsenic acid induces apoptosis in OC3 oral cavity cancer cells. [Journal Article]
    Mol Med Rep. 2023 02; 27(2)Wu SZ, Lan YY, … Huang BM
  • Although arsenic is an environmental toxicant, arsenic trioxide (ATO) is used to treat acute promyelocytic leukemia (APL) with anticancer effects. Studies have demonstrated oral cancer is in the top 10 cancers in Taiwan. High rate of oral cancers is linked to various behaviors, such as excessive alcohol consumption and tobacco use. Similarly, betel chewing is a strong risk factor in oral cancer. …
  • Clinical characteristics of a patient with de novo acute promyelocytic leukemia with JAK2 v617f mutation. [Case Reports]
    Hematology. 2022 Dec; 27(1):1290-1293.Jiang YZ, Wei ZL, … Huang DP
  • CONCLUSIONS: A de novo APL patient presented initially with JAK2 V617F. After ATRA and ATO dual induction and chemotherapy consolidation, the patient achieved complete remission (CR) with undetectable PML/RARα. However, the JAK2 V617F remained positive, and the patient developed MPN (PV/ET) 22 months later, which responded well to interferon therapy.AML, acute myeloid leukemia; APL, acute promyelocytic leukemia; ATRA, all-trans retinoic acid; ATO, arsenic trioxide; BM, bone marrow; CR, complete remission; ET, essential thrombocythemia; Hb, hemoglobin; JAK2, Janus-associated kinase 2; MPN, myeloproliferative neoplasms; PLT, platelets; PMF, primary myelofibrosis; PML/RARα; PV, polycythemia vera; WBC, white blood cells.
  • Development of Acute Promyelocytic Leukemia in a Patient with Granulomatosis with Polyangiitis: A Case Report. [Case Reports]
    Tohoku J Exp Med. 2023 Jan 20; 259(2):107-112.Sumichika Y, Yokose K, … Migita K
  • Granulomatosis with polyangiitis (GPA) is a rare disorder of unknown etiology, which is characterized by necrotizing granulomatous inflammation of the upper respiratory system and kidneys. Immunosuppressive treatment (cyclophosphamide or azathioprine with glucocorticoids) improved the outcome of GPA, however, latent comorbidity (cancers and hematologic malignancies) has become more prevalent in r…
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