- Cuban Application of Two Methods for Analyzing Multiple Causes of Death. [Journal Article]
- MRMEDICC Rev 2018; 20(3):30-35
- CONCLUSIONS: The multiple causes of death approach affords more nuanced understanding of patterns of disease, comorbidity and death in the Cuban population. The indicators used fulfill different roles: the simple method brings to light the full range of ways in which a given cause contributes to mortality, and the cause-of-death association indicator enables exploration of links between different causes of death, not possible with the simple method. KEYWORDS Mortality, multifactorial causality, causes of death, diabetes mellitus, Cuba.
- Whole-exome sequencing identifies novel mutations in genes responsible for retinitis pigmentosa in 2 nonconsanguineous Chinese families. [Journal Article]
- IJInt J Ophthalmol 2019; 12(6):915-923
- CONCLUSIONS: We identify 2 novel mutations in genes responsible for autosomal recessive RP, and the mutation in FAM161A is reported for the first time in a Chinese population. Our result not only enriches the knowledge of the mutation frequency and spectrum in the genes responsible for nonsyndromic RP but also provides a new target for future gene therapy.
- Endothelin-1-Induced Microvascular ROS and Contractility in Angiotensin-II-Infused Mice Depend on COX and TP Receptors. [Journal Article]
- AAntioxidants (Basel) 2019 Jun 22; 8(6)
- CONCLUSIONS: Activation of vascular TPRs by COX products are required for ET-1 to increase vascular contractions and ROS generation from NADPH oxidase and reduce ROS metabolism by SOD. These effects require an increase in these systems by prior infusion of Ang II.
- Site specific absence of Microfibrillar protein 4 (MFAP4) from the internal elastic membrane of arterioles in the rheumatoid arthritis synovial membrane. An immunohistochemical study in patients with advanced rheumatoid arthritis versus osteoarthritis. [Journal Article]
- AAPMIS 2019 Jun 24
- Microfibrillar associated protein 4 (MFAP4) is a non-structural matrix protein with cell regulatory activities and a potential as seromarker for fibrosis. We aimed to study the occurrence of MFAP4 in…
Microfibrillar associated protein 4 (MFAP4) is a non-structural matrix protein with cell regulatory activities and a potential as seromarker for fibrosis. We aimed to study the occurrence of MFAP4 in the synovial membrane from patients with rheumatoid arthritis (RA) versus osteoarthritis (OA). Formaldehyde-fixed synovial tissue sections, from patients with RA (N=6) and OA (N=6) undergoing total hip arthroplasty, were deparaffinized and immunostained with monoclonal antibodies against MFAP4. Elastin was detected using ElastiKit. MFAP4 in serum (sMFAP4) and synovial fluid was measured by an immunoassay. MFAP4 was present in synovial biopsies from both RA and OA patients, particularly prominent in deep arterioles where it colocalized with elastin. Notably however, MFAP4 was absent from the internal elastic lamina in RA arterioles irrespective of disease duration and synovitis activity, while present although with irregular staining patterns in OA specimens. sMFAP4 was increased in RA and OA serum versus healthy controls: median (interquartile range) 29.8 (25.3-39.1) and 25.5 U/l (18.1-43.3) versus 17.7 U/l (13.7-21.2), p=0.006 and p=0.02, respectively The concentration of synovial fluid was lower than in serum in both RA and OA. These findings may suggest that MFAP4 is involved in adaptive vessel wall remodeling associated with chronic joint disease. This article is protected by copyright. All rights reserved.
- Subclassification and Treatment Results of Ethanol Embolotherapy of Type II Arteriovenous Malformations of the Extremity and Body. [Journal Article]
- JVJ Vasc Interv Radiol 2019 Jun 19
- CONCLUSIONS: The cure rate of type IIa AVMs was significantly better than that of type IIc AVMs, which also required significantly more treatment sessions than the other 2 types.
- A mathematical model for the first derivative wave analysis of the volumetric capnogram from the perspective of erythrocyte motion profiles. [Journal Article]
- HHeliyon 2019; 5(6):e01824
- Current trends in monitoring system are leading to the adoption of volumetric capnogram (Vcap). The first derivative wave analysis (FDWA) of Vcap represented the cardiogenic oscillations (CarO) as a …
Current trends in monitoring system are leading to the adoption of volumetric capnogram (Vcap). The first derivative wave analysis (FDWA) of Vcap represented the cardiogenic oscillations (CarO) as a propagated wave and the slope of phase III (SIII) as a constant. Until today the genesis of CarO and SIII is however under debate. In this study, we defined motion profiles of erythrocytes in the pulmonary parenchyma as pulsated-run and random-walk, on the basis of which we obtained a new mathematical expression describing FDWA of Vcap. The mathematical model of Vcap provided theoretical explanation concerned with motion profiles of erythrocytes about the genesis of CarO and SIII. As the results, the mathematical model predicted the close relationship between SIII and the transfer factor of carbon monoxide, which will be used for estimating validity of this mathematical model. In addition, the velocity of propagated wave in the phase III was suggested as a new physiological variable to estimate elastic properties of pulmonary arterioles, and a new measuring method of VD was proposed based on the theoretical reason, as well. Clinical investigations of the new VD to test its efficacy of monitoring are needed.
- Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes. [Journal Article]
- SciScience 2019 Jun 20
- Cerebral blood flow is reduced early in Alzheimer's disease (AD). Because most of the vascular resistance within the brain is in capillaries, this could reflect dysfunction of contractile pericytes o…
Cerebral blood flow is reduced early in Alzheimer's disease (AD). Because most of the vascular resistance within the brain is in capillaries, this could reflect dysfunction of contractile pericytes on capillary walls. Here we used live and rapidly-fixed biopsied human tissue to establish disease-relevance, and rodent experiments to define mechanism. We found that, in humans with cognitive decline, amyloid β (Aβ) constricts brain capillaries at pericyte locations. This was caused by Aβ generating reactive oxygen species, which evoked the release of endothelin-1 (ET) that activated pericyte ETA receptors. Capillary, but not arteriole, constriction also occurred in vivo in a mouse model of AD. Thus, inhibiting the capillary constriction caused by Aβ could potentially reduce energy lack and neurodegeneration in AD.
- Expression of a constitutively active human STING mutant in hematopoietic cells produces an Ifnar1-dependent vasculopathy in mice. [Journal Article]
- LSLife Sci Alliance 2019; 2(3)
- STING-associated vasculopathy with onset in infancy (SAVI) is an autoinflammatory disorder characterized by blood vessel occlusions, acral necrosis, myositis, rashes, and pulmonary inflammation that …
STING-associated vasculopathy with onset in infancy (SAVI) is an autoinflammatory disorder characterized by blood vessel occlusions, acral necrosis, myositis, rashes, and pulmonary inflammation that are the result of activating mutations in the STimulator of Interferon Genes (STING). We generated a transgenic line that recapitulates many of the phenotypic aspects of SAVI by targeting the expression of the human STING-N154S-mutant protein to the murine hematopoietic compartment. hSTING-N154S mice demonstrated failure to gain weight, lymphopenia, progressive paw swelling accompanied by inflammatory infiltrates, severe myositis, and ear and tail necrosis. However, no significant lung inflammation was observed. X-ray microscopy imaging revealed vasculopathy characterized by arteriole occlusions and venous thromboses. Type I interferons and proinflammatory mediators were elevated in hSTING-N154S sera. Importantly, the phenotype was prevented in hSTING-N154S mice lacking the type I interferon receptor gene (Ifnar1). This model, based on a mutant human STING protein, may shed light on the pathophysiological mechanisms operative in SAVI.
- Associations of Infant Sleep Duration with Body Composition and Cardiovascular Health to Mid-Adolescence: The PEAS Kids Growth Study. [Journal Article]
- COChild Obes 2019 Jun 20
- CONCLUSIONS: We found no evidence that sleep duration very early in life affects adolescent body composition or cardiovascular health.
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- Home-HIT improves muscle capillarisation and eNOS/NAD(P)Hoxidase protein ratio in obese individuals with elevated cardiovascular disease risk. [Journal Article]
- JPJ Physiol 2019 Jun 19
- CONCLUSIONS: Obesity and sedentary behaviour are associated with capillary rarefaction and impaired muscle microvascular vasoreactivity, due to reduced nitric oxide bioavailability. Low-volume high-intensity interval training (HIT) is a time-efficient alternative to traditional moderate-intensity continuous training (MICT), but its effect on the muscle microvasculature has not been studied. The applicability of current lab- and gym-based HIT protocols for obese individuals with low fitness and mobility has been disputed by public health experts, who cite the strenuous nature and complex protocols as major barriers. Therefore, we developed a virtually-supervised HIT protocol targeting this group that can be performed at home without equipment (Home-HIT). This study is the first to show that 12-weeks of virtually-supervised Home-HIT in obese individuals with elevated CVD risk leads to similar increases in capillarisation and eNOS/NAD(P)Hoxidase protein ratio within the muscle microvascular endothelium as virtually-supervised home-based MICT and laboratory-based HIT, while reducing many of the major barriers to exercise.