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870,718 results
  • Cardiac protection of Bauhinia championii against reperfusion injury. [Journal Article]
    Environ Toxicol 2020Chen YF, Chen WY, … Lee AS
  • This study aims to investigate the protective effects of the Bauhinia championii (BC) against ischemia/reperfusion (I/R)-induced injury in an isolated heart model. Langendorff-perfused C57BL/6JNarl mice hearts were performed with 30 minutes ischemia and 60 minutes reperfusion by left anterior descending artery ligation. Before reperfusion, boiling water extracts of BC (10 mg/L) was pretreated for…
  • Implication of in vivo circulating fibrocytes ablation in experimental pulmonary hypertension murine model. [Journal Article]
    Br J Pharmacol 2020Nikam VS, Nikam S, … Voswinckel R
  • CONCLUSIONS: Our data demonstrate that circulating fibrocytes ablation has a potential impact on right ventricular hypertrophy and vascular remodelling in the setting of experimental PH induced by hypoxia. The beneficial effects may be related to the direct contribution of fibrocytes or its paracrine effect on other resident cell types. Thus, clinical manipulation of circulating fibrocytes may represent a novel therapeutic approach to ameliorate disease state in PH.
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