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403,244 results
  • Functional role of hedgehog pathway in osteoarthritis. [Review]
    Cell Biochem Funct 2019Xiao WF, Li YS, … He M
  • The hedgehog signalling pathway is one of the key regulators of metazoan development, and it plays an important role in the regulation of a variety of developmental and physiological processes. But it is aberrantly activated in many human diseases, including osteoarthritis (OA). In this study, we have reviewed the association of hedgehog signalling pathway in the development and progression of OA…
  • Exploring inflammatory signatures in arthritic joint biopsies with Spatial Transcriptomics. [Journal Article]
    Sci Rep 2019; 9(1):18975Carlberg K, Korotkova M, … Malmström V
  • Lately it has become possible to analyze transcriptomic profiles in tissue sections with retained cellular context. We aimed to explore synovial biopsies from rheumatoid arthritis (RA) and spondyloarthritis (SpA) patients, using Spatial Transcriptomics (ST) as a proof of principle approach for unbiased mRNA studies at the site of inflammation in these chronic inflammatory diseases. Synovial tissu…
  • Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases. [Journal Article]
    PLoS One 2019; 14(12):e0226479Svanteson M, Rollefstad S, … Semb AG
  • CONCLUSIONS: A progression of total atherosclerotic plaque volume in statin-treated patients with IJD was observed. However, soft/mixed plaque volume was reduced, suggesting an alteration in plaque composition. Patients with recommended LDL-c levels at follow-up had reduced atherosclerotic progression compared to patients with LDL-c levels above the treatment target, suggesting a beneficial effect of treatment to guideline-recommended lipid targets in IJD patients.
  • Impact of cadmium toxicity on cartilage loss in a 3D in vitro model. [Journal Article]
    Environ Toxicol Pharmacol 2019; 74:103307Yessica Eduviges ZC, Martínez-Nava G, … Martínez-Flores K
  • Osteoarthritis (OA) is the gradual loss of articular cartilage and decrease in subchondral space. One of the risk factors Exposure to cadmium (Cd) through tobacco smoke has been identified as a major OA risk factor. There are no reports addressing the role of Cd in OA progression at the molecular level. Our findings revealed that Cd can promote the activation of metalloproteinases (MMP1, MMP3, MM…
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