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184,465 results
  • Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. [Journal Article]
    Nat Commun 2019; 10(1):5573Gusach A, Luginina A, … Cherezov V
  • Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. While selective inhibition of CysLT1R has been used for treating asthma and associated diseases for over two decades, CysLT2R has recently started to emerge as a potential drug target against atopic asthma, brain injury and central nervous system disorders, a…
  • Validation of an App-based Portable Spirometer in Adolescents with Asthma. [Journal Article]
    J Asthma 2019; :1-10Ring B, Burbank AJ, … Hernandez ML
  • Objectives: Objective measurements of asthma impairment could aid teens in recognition of changes in asthma status over time. Ready access to a conventional spirometer is not realistic outside of the clinical setting. In this proof-of-concept study, we compared the performance of the VitalFlo mobile spirometer to the nSpire KoKo® sx1000 spirometer for accuracy in measuring Forced Expiratory Volu…
  • NAT1 genetic variation increases asthma risk in children with secondhand smoke exposure. [Journal Article]
    J Asthma 2019; :1-9Brooks CC, Martin LJ, … Biagini Myers JM
  • CONCLUSIONS: Variation in the NAT1 gene modifies asthma risk in children exposed to secondhand-smoke. To our knowledge, this is the first report of a gene-environment interaction between NAT1 variants, smoke exposure, cotinine levels, and pediatric asthma. NAT1 genotype may have clinical utility as a biomarker of increased asthma risk in children exposed to smoke.
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