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6 results
  • Retinoic acid-induced asymmetric craniofacial growth and cleft palate in the TO mouse fetus. [Journal Article]
    Reprod Toxicol 1997 Nov-Dec; 11(6):843-60Padmanabhan R, Ahmed I
  • The etiology and pathogenetic mechanisms of cleft palate (CP) are rather uncertain. Both genetic and environmental factors are known to cause failure of horizontalization and/or failure of fusion of the palatal shelves resulting in CP. Retinoic acid (RA)-induced CP in the mouse is reported to exhibit two peaks of incidence separated by a less sensitive window. The morphologic bases of the differe…
  • Astomia-agnathia-holoprosencephaly association. Prenatal diagnosis of a new case. [Case Reports]
    Prenat Diagn 1991; 11(3):199-203Rolland M, Sarramon MF, Bloom MC
  • A case of agnathia-astomia-holoprosencephaly with prenatal ultrasound diagnosis at 23 weeks is reported and discussed. This lethal neurocristopathy, well known in mammalians, is rarely observed in humans. Prenatal diagnosis features are intrauterine growth retardation, mandibular absence or major hypoplasia, holoprosencephaly, cyclopia or hypotelorism, and in some instances frontal proboscis. Thi…
  • Cyclopia-synotia: an unusual presentation. [Case Reports]
    J Craniofac Genet Dev Biol 1989; 9(3):231-8Kramer B, Stein BA, Grace HJ
  • An infant showing an unusual combination of craniofacial abnormalities is described. Synotia, astomia, a rudimentary proboscis, and a central placode in the hairline were observed. Serial sections of the head were examined microscopically. The proboscis contained a mass of striated muscle, but no bony or nervous tissue. Cyclopia was suggested by the central placode, the latter consisting of a thi…
  • Monozygotic twin aborted fetuses discordant for holoprosencephaly/synotia. [Case Reports]
    Teratology 1985; 31(2):203-15Machin GA, Sperber GH, Wootliffe J
  • A pair of monozygotic twin fetuses aborted at 15 weeks were found to be discordant for holoprosencephaly and synotia. They were studied grossly, radiologically, and histologically. Features of first brancial arch dysplasia (synotia, agnathia, and astomia) and holoprosencephaly (absent ethmoid bone and Rathke's pouch) observed in one twin were contrasted with minimal dysmorphology in the co-twin. …
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