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1,609 results
  • [Supervised off-label prescribing of methylphenidate in adult ADHD]. [Journal Article]
  • EEncephale 2018 Aug 16
  • Carton L, Dondaine T, … Ménard O
  • CONCLUSIONS: When an off-label prescription is being considered, it must comply with the basic rules of good clinical practice, and the benefit/risk ratio should be constantly reassessed. The proposed multidisciplinary framework, adapted to the characteristics of adult ADHD and the pharmacological properties of methylphenidate, appears to be an interesting strategy to meet the requirements of the good clinical practice. The complementary assessments carried out and the collegial framework allow enhancing the patient's follow-up and minimize the drug risk, particularly in the psychiatric, addictive and cardiovascular adverse events. Finally, this framework could also help the monitoring of other off-label treatments for ADHD, such as atomoxetine or guanfacine.
  • Drugs and Lactation Database (LactMed) [BOOK]
  • BOOKNational Library of Medicine (US): Bethesda (MD)
  • There is no published experience with atomoxetine during breastfeeding, although reports from the manufacturer found no serious advese effects in two breastfed infants. An alternate drug may be prefe...
  • Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders. [Review]
  • CDCochrane Database Syst Rev 2018 06 26; 6:CD007990
  • Osland ST, Steeves TD, Pringsheim T
  • CONCLUSIONS: Following an updated search of potentially relevant studies, we found no new studies that matched our inclusion criteria and thus our conclusions have not changed.Methylphenidate, clonidine, guanfacine, desipramine, and atomoxetine appear to reduce ADHD symptoms in children with tics though the quality of the available evidence was low to very low. Although stimulants have not been shown to worsen tics in most people with tic disorders, they may, nonetheless, exacerbate tics in individual cases. In these instances, treatment with alpha agonists or atomoxetine may be an alternative. Although there is evidence that desipramine may improve tics and ADHD in children, safety concerns will likely continue to limit its use in this population.
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