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(atovaquone)
1,444 results
  • Single-Chain Polymer Nanoparticles Targeting the Ookinete Stage of Malaria Parasites. [Journal Article]
    ACS Infect Dis. 2023 Jan 13; 9(1):56-64.Hamelmann NM, Paats JD, … Paulusse JMJ
  • Malaria is an infectious disease transmitted by mosquitos, whose control is hampered by drug resistance evolution in the causing agent, protist parasites of the genus Plasmodium, as well as by the resistance of the mosquito to insecticides. New approaches to fight this disease are, therefore, needed. Research into targeted drug delivery is expanding as this strategy increases treatment efficacies…
  • Unveiling the membrane bound dihydroorotate: Quinone oxidoreductase from Staphylococcus aureus. [Journal Article]
    Biochim Biophys Acta Bioenerg. 2022 Dec 06; 1864(2):148948.Sousa FM, Pires P, … Pereira MM
  • Staphylococcus aureus is an opportunistic pathogen and one of the most frequent causes for community acquired and nosocomial bacterial infections. Even so, its energy metabolism is still under explored and its respiratory enzymes have been vastly overlooked. In this work, we unveil the dihydroorotate:quinone oxidoreductase (DHOQO) from S. aureus, the first example of a DHOQO from a Gram-positive …
  • A pharmacokinetic-pharmacodynamic model for chemoprotective agents against malaria. [Journal Article]
    CPT Pharmacometrics Syst Pharmacol. 2023 Jan; 12(1):50-61.Cherkaoui-Rbati MH, Andenmatten N, … Gobeau N
  • Chemoprophylactics are a vital tool in the fight against malaria. They can be used to protect populations at risk, such as children younger than the age of 5 in areas of seasonal malaria transmission or pregnant women. Currently approved chemoprophylactics all present challenges. There are either concerns about unacceptable adverse effects such as neuropsychiatric sequalae (mefloquine), risks of …
  • Rare Case of Persistently Depressed T Lymphocyte Subsets After SARS-CoV-2 Infection. [Case Reports]
    Am J Case Rep. 2022 Nov 01; 23:e937760.Alebna PL, Bellamy S, … Mangia A
  • BACKGROUND On rare occasions, viral infections are known to also depress immune cell lines, further worsening clinical outcomes. We describe a patient who presented 3 weeks after recovery from mild COVID-19 disease with clinical features of an atypical pneumonia and was found to have a low CD4+ T-cell count. CASE REPORT An 82-year-old man with a past medical history of coronary artery disease, rh…
  • Global scenario of Plasmodium vivax occurrence and resistance pattern. [Review]
    J Basic Microbiol. 2022 Dec; 62(12):1417-1428.Kaur D, Sinha S, Sehgal R
  • Malaria caused by Plasmodium vivax is comparatively less virulent than Plasmodium falciparum, which can also lead to severe disease and death. It shows a wide geographical distribution. Chloroquine serves as a drug of choice, with primaquine as a radical cure. However, with the appearance of resistance to chloroquine and treatment has been shifted to artemisinin combination therapy followed by pr…
  • Human Babesiosis. [Review]
    Infect Dis Clin North Am. 2022 09; 36(3):655-670.Waked R, Krause PJ
  • Babesiosis is caused by intraerythrocytic parasites that are transmitted primarily by ticks, infrequently through blood transfusion, and rarely through transplacental transmission or organ transplantation. Human babesiosis is found throughout the world, but the incidence is highest in the Northeast and upper Midwestern United States. Babesiosis has clinical features that resemble malaria and can …
  • Efficacy of three anti-malarial regimens for uncomplicated Plasmodium falciparum malaria in Cambodia, 2009-2011: a randomized controlled trial and brief review. [Review]
    Malar J. 2022 Sep 07; 21(1):259.Lek D, Rachmat A, … Rogers WO
  • CONCLUSIONS: This study was conducted at the epicentre of substantial multi-drug resistance that emerged soon thereafter. Occurring early in the national transition from AS/MQ to DHA/PPQ, both DHA/PPQ and ATQ/PG had acceptable efficacy against uncomplicated falciparum malaria. However, efficacy of AS/MQ was only 80% with apparent mefloquine resistance based on elevated Pfmdr1 copy number and IC50. By 2009, there was already significant evidence of artemisinin resistance not previously reported at the Northern Cambodia-Thai border. This study suggests the basis for early development of significant DHA/PPQ failures within 3 years of introduction. Artemisinin resistance likely occurred on the Northern border concurrently with that reported along the Western border in Pailin. Trial registration This legacy trial was conducted prior to International Committee of Medical Journal Editors' requirements for preregistration on ClinicalTrials.gov. The full protocol has been provided.
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