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2,728 results
  • Anti-ageing effects of FDA-approved medicines: a focused review. [Review]
    J Basic Clin Physiol Pharmacol. 2023 Jan 13 [Online ahead of print]Thanapairoje K, Junsiritrakhoon S, … Supharattanasitthi W
  • Ageing is the process generated by senescent cells, free radicals, inflammation and other relevant factors. Ageing contributes to age-related diseases that affect the quality of life. People are interested in anti-ageing intervention and many scientists attempt to search for anti-ageing medicines. This review focused on describing in vivo anti-ageing activity of US-FDA-approved drugs and found th…
  • Premedication Propofol Dose to Prevent Emergency Delirium. [Journal Article]
    Iran J Psychiatry. 2022 Jul; 17(3):304-311.Shafa A, Rajabi F, … Habibzadeh MR
  • Objective: One of the most common complications in general anesthesia is the Emergence delirium (ED). Many agents have been studied for prevention of ED, among which propofol has been successfully used. However, there is no information about the optimal dosage of this agent considering the ultimate outcome and the adverse effects; therefore, aimed to assess in this study. Method : 70 children und…
  • Drugs and Lactation Database (LactMed): Atracurium [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • No information is available on the use of atracurium during breastfeeding. Because it is short acting, highly polar and poorly absorbed orally, it is not likely to reach the breastmilk in high concentration or to reach the bloodstream of the infant.[1,2] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the …
  • A Comparison of the Effect of Isoflurane and Propofol on Liver Enzymes. [Journal Article]
    J West Afr Coll Surg. 2022 Apr-Jun; 12(2):28-33.Oladimeji MA, Desalu I, … Adesida AA
  • CONCLUSIONS: Both agents had a varied effect on liver enzymes. Isoflurane resulted in a significantly higher increase in 24 hours post-operative serum AST than propofol. Propofol caused a significant increase in 24 hours post-operative total bilirubin. Caution is therefore recommended in their use in patients with altered liver enzymes.
  • StatPearls: Neuromuscular Blockade [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)CookDanielleDUPMC PinnacleSimonsDavid J.DJUPMC LititzBOOK
  • Neuromuscular blockade is frequently used in anesthesia to facilitate endotracheal intubation, optimize surgical conditions, and assist with mechanical ventilation in patients who have reduced lung compliance. Neuromuscular blocking agents (NMBAs) come in two forms: depolarizing neuromuscular blocking agents (e.g., succinylcholine) and nondepolarizing neuromuscular blocking agents (e.g., rocuroni…
  • StatPearls: Non-depolarizing Neuromuscular Blockers [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)ClarDerek T.DTCampbell University SOMLiuMarkMSan Antonio Military Medical CenterBOOK
  • Non-depolarizing neuromuscular blockers (nNMBs) are administered as primary therapy in facilitating endotracheal intubations and adjuvant therapy in the perioperative maintenance of anesthesia and care of the critically ill patient. Primarily nNMBs (rocuronium, vecuronium, pancuronium, atracurium, cisatracurium, mivacurium) are used to facilitate airway management and decrease the risk of larynge…
  • StatPearls: Atracurium [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)RitzMatthew L.MLMayo Clinic Hospital ArizonaDerianArmenAMayo ClinicBOOK
  • Atracurium is indicated as an addition to general anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation. Atracurium is a non-depolarizing neuromuscular blocking drug of the benzylisoquinolinium class. It competes with acetylcholine for binding sites. This activity outlines the indications, mechanism of action, safe adminis…
  • StatPearls: Pancuronium [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)DasGyan N.GNSan Antonio Military Medical CenterSharmaPiyushPSaint James School Of MedicineMaaniChristopher V.CVUS ArmyBOOK
  • Pancuronium bromide is a long-acting, bis-quaternary aminosteroid, non-depolarizing, neuromuscular blocking drug (NMBD), which was first synthesized in 1964 and found to possess fewer adverse effects with regards to hemodynamic stability and histamine release as compared to the prototypical NMBD, d-tubocurarine. After the arrival of intermediate-acting NMBDs such as vecuronium, rocuronium, cisatr…
  • Biosynthesis of tetrahydropapaverine and semisynthesis of papaverine in yeast. [Journal Article]
    Proc Natl Acad Sci U S A. 2022 08 16; 119(33):e2205848119.Jamil OK, Cravens A, … Smolke CD
  • Tetrahydropapaverine (THP) and papaverine are plant natural products with clinically significant roles. THP is a precursor in the production of the drugs atracurium and cisatracurium, and papaverine is used as an antispasmodic during vascular surgery. In recent years, metabolic engineering advances have enabled the production of natural products through heterologous expression of pathway enzymes …
  • [Does NoL monitoring affect opioid consumption during da Vinci prostatectomy?] [Randomized Controlled Trial]
    Anaesthesiologie. 2022 09; 71(9):683-688.Niebhagen F, Golde C, … Hübler M
  • CONCLUSIONS: The use of PMD200 did not significantly reduce cumulative opioid consumption. Following on we must reject the initial hypothesis. The difference in sufentanil bolus variances may point to an individualized antinociceptive therapy when NoL monitoring is used. We suppose patients with high opioid demands are detected and patients with low opioid demands did not receive unnecessary opioids. This assumption is only true if the PMD200 measures the entity pain. Further studies with more participants during surgery with higher tissue damage could lead to more convincing data and conclusions.
  • Interactions of the protease inhibitor, ritonavir, with common anesthesia drugs. [Review]
    Paediatr Anaesth. 2022 10; 32(10):1091-1099.Svedmyr A, Hack H, Anderson BJ
  • The protease inhibitor, ritonavir, is a strong inhibitor of CYP 3A. The drug is used for management of the human immunovirus and is currently part of an oral antiviral drug combination (nirmatrelvir-ritonavir) for the early treatment of SARS-2 COVID-19-positive patients aged 12 years and over who have recognized comorbidities. The CYP 3A enzyme system is responsible for clearance of numerous drug…
  • Residual neuromuscular blockade in the ICU: a prospective observational study and national survey. [Journal Article]
    Anaesthesia. 2022 09; 77(9):991-998.Ross J, Ramsay DP, … Moore JE
  • Residual neuromuscular blockade is associated with significant morbidity. It has been widely studied in anaesthesia; however, the incidence of residual neuromuscular blockade in patients managed in the ICU is unknown. We conducted a prospective observational study in a tertiary ICU to determine the incidence of residual neuromuscular blockade using quantitative accelerographic monitoring. We test…
  • StatPearls: Cisatracurium [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)StrawbridgeAndrew D.ADSan Antonio Uniformed Services HECKhannaNiloufar R.NRCalifornia Northstate UniversityHauserJoshua M.JMBrooke Army Medical CenterBOOK
  • Cisatracurium besylate is an intermediate-acting, non-depolarizing neuromuscular blocking drug (NMBD). Cisatracurium has a benzylisoquinolinium structure and is the 1R cis-1-prime R cis isomer of atracurium. As an NMBD, it has found use as an adjunct to general anesthesia facilitating tracheal intubation and providing skeletal muscle relaxation during surgery. It may also be used to provide skele…
  • Redistribution of critical drugs in shortage during the first wave of COVID-19 in France: from operating theaters to intensive care units. [Journal Article]
    J Pharm Policy Pract. 2022 Apr 01; 15(1):28.Chapuis C, Collomp R, … Albaladejo P
  • CONCLUSIONS: Variation of dispensations between CCU and others was directly related to the increase of COVID patients in CCU and the decrease in surgical activity. Each establishment could receive up to five or six different presentations and concentrations, leading to a major risk of medication error. This collaborative national survey provided accurate data on the drugs' usual consumption. This work emphasized the need for a strong collaboration between pharmacists and anesthesiologists and intensive care physicians. It was further used by the Health Ministry to adjust the drug distribution.
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