- Comparison of different doses of atracurium for quality of muscle relaxation during modified rapid sequence induction in emergency laparotomy: A prospective randomised double blind study. [Journal Article]
- CONCLUSIONS: Acceptable intubating conditions can be achieved in a minute with the use of a high dose of atracurium (1 mg/kg) during RSI. Hence, atracurium can be used as an alternative drug for RSI.
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- Pectoral Nerve Blocks for Transvenous Subpectoral pacemaker insertion in Children: Randomized Controlled Trial. [Journal Article]Korean J Anesthesiol. 2023 Jan 12 [Online ahead of print]KJ
- CONCLUSIONS: Ultrasound guided PECs have a good intraoperative hemodynamic profile, reduce postoperative pain scores, and lower total opioid usage in children who underwent transvenous subpectoral pacemaker placement.
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- Anti-ageing effects of FDA-approved medicines: a focused review. [Review]J Basic Clin Physiol Pharmacol. 2023 Jan 13 [Online ahead of print]JB
- Ageing is the process generated by senescent cells, free radicals, inflammation and other relevant factors. Ageing contributes to age-related diseases that affect the quality of life. People are interested in anti-ageing intervention and many scientists attempt to search for anti-ageing medicines. This review focused on describing in vivo anti-ageing activity of US-FDA-approved drugs and found th…
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- Premedication Propofol Dose to Prevent Emergency Delirium. [Journal Article]
- Objective: One of the most common complications in general anesthesia is the Emergence delirium (ED). Many agents have been studied for prevention of ED, among which propofol has been successfully used. However, there is no information about the optimal dosage of this agent considering the ultimate outcome and the adverse effects; therefore, aimed to assess in this study. Method : 70 children und…
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- Drugs and Lactation Database (LactMed): Atracurium [BOOK]Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
- No information is available on the use of atracurium during breastfeeding. Because it is short acting, highly polar and poorly absorbed orally, it is not likely to reach the breastmilk in high concentration or to reach the bloodstream of the infant.[1,2] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the …
- Comparison of laryngeal mask airway (LMA) insertion with and without muscle relaxant in pediatric anesthesia; a randomized clinical trial. [Journal Article]
- CONCLUSIONS: In some pediatric anesthesia, the use of atracurium, as a muscle relaxant had no significant effect on capability of LMA insertion, maintaining airway patency, LMA seal pressure and oxygenation variations. Moreover, it did not have a preventive effect on the occurrence of complications such as laryngospasm.
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- Effects of midazolam co-induction to general anesthesia: A randomized clinical trial. [Randomized Controlled Trial]
- CONCLUSIONS: Midazolam co-induction prevented a marked decline in SAP/MAP/DAP immediately after induction of GA, led to reduced postoperative anxiety and cortisol response to surgery, and reduced propofol requirements for induction.
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- Comparison of onset time, duration of action, and intubating conditions after cisatracurium 0.15 mg/kg in young and elderly patients. [Journal Article]
- CONCLUSIONS: In elderly patients cisatracurium 0.15 mg/kg had significantly longer onset time and duration of action compared with younger patients. No difference was found in intubating conditions at a TOF count of 0.
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- Impact of intravenous dexamethasone on the initiation and recovery of atracurium in children: A double-blinded randomized controlled trial. [Randomized Controlled Trial]Paediatr Anaesth. 2023 02; 33(2):123-128.PA
- CONCLUSIONS: Application of a single bolus dose (0.15 mg/kg) of dexamethasone during induction does not attenuate atracurium-induced neuromuscular blockade in children.
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- Premedication with Diclofenac and Precurarization with Atracurium on Succinylcholine-Induced Myalgia in Laparoscopic Cholecystectomy: A Double-Blinded Randomized Study. [Journal Article]
- CONCLUSIONS: Succinylcholine-induced myalgia has a complex pathophysiology. However, the preemptive use of diclofenac in combination with precurarization can alleviate the incidence and severity of succinylcholine-induced myalgia. Therefore, its use may be considered in routine cases for induction of anesthesia for facilitating laryngoscopy and endotracheal intubation.
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- A Comparison of the Effect of Isoflurane and Propofol on Liver Enzymes. [Journal Article]
- CONCLUSIONS: Both agents had a varied effect on liver enzymes. Isoflurane resulted in a significantly higher increase in 24 hours post-operative serum AST than propofol. Propofol caused a significant increase in 24 hours post-operative total bilirubin. Caution is therefore recommended in their use in patients with altered liver enzymes.
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- StatPearls: Neuromuscular Blockade [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Neuromuscular blockade is frequently used in anesthesia to facilitate endotracheal intubation, optimize surgical conditions, and assist with mechanical ventilation in patients who have reduced lung compliance. Neuromuscular blocking agents (NMBAs) come in two forms: depolarizing neuromuscular blocking agents (e.g., succinylcholine) and nondepolarizing neuromuscular blocking agents (e.g., rocuroni…
- Can late- or two-step administration of neostigmine reduce the reversal time of cisatracurium-induced moderate neuromuscular blockade?: A prospective, randomised controlled clinical trial. [Randomized Controlled Trial]Eur J Anaesthesiol. 2023 02 01; 40(2):140-143.EJ
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- StatPearls: Non-depolarizing Neuromuscular Blockers [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Non-depolarizing neuromuscular blockers (nNMBs) are administered as primary therapy in facilitating endotracheal intubations and adjuvant therapy in the perioperative maintenance of anesthesia and care of the critically ill patient. Primarily nNMBs (rocuronium, vecuronium, pancuronium, atracurium, cisatracurium, mivacurium) are used to facilitate airway management and decrease the risk of larynge…
- Sample size considerations for studies comparing intubating conditions using quantitative monitoring versus a fixed interval during onset of neuromuscular blockade. [Journal Article]Anaesth Crit Care Pain Med. 2022 12; 41(6):101154.AC
- Data in the literature are still scarce to establish any recommendations on the use of quantitative monitoring during tracheal intubation.
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- A comparison between cisatracurium and rocuronium-induced neuromuscular block on laryngeal electromyography recovery after neostigmine reversal in a porcine model. [Journal Article]
- CONCLUSIONS: This porcine model demonstrated that neostigmine provides an adequate and timely IONM signal suppressed by both cisatracurium and rocuronium. These results can potentially expand the options for precision neuromuscular block management during IONM to improve vocal outcomes in thyroid surgery patients.
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- StatPearls: Atracurium [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Atracurium is indicated as an addition to general anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation. Atracurium is a non-depolarizing neuromuscular blocking drug of the benzylisoquinolinium class. It competes with acetylcholine for binding sites. This activity outlines the indications, mechanism of action, safe adminis…
- StatPearls: Pancuronium [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Pancuronium bromide is a long-acting, bis-quaternary aminosteroid, non-depolarizing, neuromuscular blocking drug (NMBD), which was first synthesized in 1964 and found to possess fewer adverse effects with regards to hemodynamic stability and histamine release as compared to the prototypical NMBD, d-tubocurarine. After the arrival of intermediate-acting NMBDs such as vecuronium, rocuronium, cisatr…
- Biosynthesis of tetrahydropapaverine and semisynthesis of papaverine in yeast. [Journal Article]
- Tetrahydropapaverine (THP) and papaverine are plant natural products with clinically significant roles. THP is a precursor in the production of the drugs atracurium and cisatracurium, and papaverine is used as an antispasmodic during vascular surgery. In recent years, metabolic engineering advances have enabled the production of natural products through heterologous expression of pathway enzymes …
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- [Does NoL monitoring affect opioid consumption during da Vinci prostatectomy?] [Randomized Controlled Trial]
- CONCLUSIONS: The use of PMD200 did not significantly reduce cumulative opioid consumption. Following on we must reject the initial hypothesis. The difference in sufentanil bolus variances may point to an individualized antinociceptive therapy when NoL monitoring is used. We suppose patients with high opioid demands are detected and patients with low opioid demands did not receive unnecessary opioids. This assumption is only true if the PMD200 measures the entity pain. Further studies with more participants during surgery with higher tissue damage could lead to more convincing data and conclusions.
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- Interactions of the protease inhibitor, ritonavir, with common anesthesia drugs. [Review]
- The protease inhibitor, ritonavir, is a strong inhibitor of CYP 3A. The drug is used for management of the human immunovirus and is currently part of an oral antiviral drug combination (nirmatrelvir-ritonavir) for the early treatment of SARS-2 COVID-19-positive patients aged 12 years and over who have recognized comorbidities. The CYP 3A enzyme system is responsible for clearance of numerous drug…
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- Residual neuromuscular blockade in the ICU: a prospective observational study and national survey. [Journal Article]Anaesthesia. 2022 09; 77(9):991-998.A
- Residual neuromuscular blockade is associated with significant morbidity. It has been widely studied in anaesthesia; however, the incidence of residual neuromuscular blockade in patients managed in the ICU is unknown. We conducted a prospective observational study in a tertiary ICU to determine the incidence of residual neuromuscular blockade using quantitative accelerographic monitoring. We test…
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- StatPearls: Cisatracurium [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Cisatracurium besylate is an intermediate-acting, non-depolarizing neuromuscular blocking drug (NMBD). Cisatracurium has a benzylisoquinolinium structure and is the 1R cis-1-prime R cis isomer of atracurium. As an NMBD, it has found use as an adjunct to general anesthesia facilitating tracheal intubation and providing skeletal muscle relaxation during surgery. It may also be used to provide skele…
- Malignant Hyperthermia and Cisatracurium During Severe SARS-CoV-2 Infection. [Letter]
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- Clinical Usage of Different Doses of Cis-Atracurium in Intracranial Aneurysm Surgery and Its Effect on Motor-Evoked Potentials. [Journal Article]
- The objective of this work was to investigate the effect of different doses of cis-atracurium on patients undergoing general anesthesia induction (GAI) during intracranial aneurysm surgery (ICAS). In this work, 90 patients who underwent ICAS under the elective motor-evoked potential (MEP) monitoring in the First Affiliated Hospital of Northwest University (Xi'an No. 1 Hospital) from January 2021 …
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- Comparing Important and Well-documented Potential Drug-Drug Interactions between Emergency, Medical, and Surgical ICUs of a Respiratory Referral Center. [Journal Article]
- CONCLUSIONS: The current study shows different frequency and nature of pDDIs between three types of ICUs. We recommend conducting similar studies in other settings to develop evidence-based guidance on clinically relevant pDDIs in different types of ICUs.
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- [Comparison of the anesthetic effects of mivacurium and cisatracurium besylate in laser laryngeal microsurgery]. [Journal Article]Zhonghua Yi Xue Za Zhi. 2022 Jun 07; 102(21):1574-1578.ZY
- Objective: To compare the anesthetic effects of mivacurium and cisatracurium besylate in laser laryngeal microsurgery, and to provide clinical evidence and reference for further optimization of muscle relaxation application. Methods: From October 2021 to January 2022, fifty-six patients of Beijing Tongren Hospital, Capital Medical University, scheduled for laser laryngeal microsurgery with genera…
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- Application of Intelligent Detection of Neural Signal in Depth Evaluation of Obstetrics and Gynecology Anesthesia. [Journal Article]
- In order to evaluate the application of EEG intelligent detection in gynecological anesthesia depth, the application of ANGEL-6000 EEG depth monitor in laparoscopic gynecological anesthesia was proposed. This method was applied to 60 patients who underwent elective laparoscopic gynecological surgery in our hospital from February to August 2016. Inclusion criteria were ASA i ∼ ii; the average age …
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- Redistribution of critical drugs in shortage during the first wave of COVID-19 in France: from operating theaters to intensive care units. [Journal Article]
- CONCLUSIONS: Variation of dispensations between CCU and others was directly related to the increase of COVID patients in CCU and the decrease in surgical activity. Each establishment could receive up to five or six different presentations and concentrations, leading to a major risk of medication error. This collaborative national survey provided accurate data on the drugs' usual consumption. This work emphasized the need for a strong collaboration between pharmacists and anesthesiologists and intensive care physicians. It was further used by the Health Ministry to adjust the drug distribution.
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- Effects of remifentanil on the recovery quality among pediatric candidates for dental procedures under general anesthesia. [Journal Article]
- CONCLUSIONS: Combination of propofol and remifentanil significantly reduced the time taken for recovery, discharge and agitation level compared to propofol.
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