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41,240 results
  • Electrocardiogram Recordings in Anesthetized Mice using Lead II. [Journal Article]
    J Vis Exp. 2020 Jun 20Ha TW, Oh B, Kang JO
  • The electrocardiogram is a valuable tool for evaluating the cardiac conduction system. Animal research has helped generate novel genetic and pharmacological information regarding the electrocardiogram. However, making electrocardiogram measurements in small animals in vivo, such as mice, has been challenging. To this end, we used an electrocardiogram recording method in anesthetized mice with man…
  • Roles of motor and cortical activity in sleep rebound in rat. [Journal Article]
    Eur J Neurosci. 2020 Jun 25 [Online ahead of print]Wen Y, Lv Y, … Lu J
  • Sleep pressure that builds up gradually during the extended wakefulness results in sleep rebound. Several lines of evidence, however, suggest that wake per se may not be sufficient to drive sleep rebound and that rapid eye movement (REM) and non-rapid eye movement (NREM) sleep rebound may be differentially regulated. In this study, we investigated the relative contribution of brain vs physical ac…
  • Broad spectrum treatment for ocular Insult induced by organophosphate chemical warfare agents. [Journal Article]
    Toxicol Sci. 2020 Jun 24 [Online ahead of print]Gore A
  • Warfare organophosphates (OP) nerve agents constitute one of the prime threats to mankind on the battlefield and in the scenario of civilian terror. Exposure to OP nerve agents dose-dependently result in incapacitation. They affect multiple organs, but the eye is one of the first and most frequently affected. Ocular OP insult may result in long-term miosis, impaired visual function and ocular pai…
  • Severe Intraoperative Bradycardia during Laparoscopic Cholecystectomy due to Rapid Peritoneal Insufflation. [Case Reports]
    Case Rep Anesthesiol. 2020; 2020:8828914.Heyba M, Khalil A, Elkenany Y
  • Laparoscopy is becoming increasingly popular in gynecological and general surgical operations. There are complications that are inherent to the laparoscopy techniques; amongst them is intraoperative vagal-mediated bradycardia that results from peritoneal stretching. This can occur due to high flow rate of gas during peritoneal insufflation, a practice still happening nowadays. We report a case of…
  • Functional atropine sensitive purinergic responses in the healthy rat bladder. [Journal Article]
    Auton Neurosci. 2020 Jun 09; 227:102693.Stenqvist J, Carlsson T, … Aronsson P
  • While acetylcholine is regarded to be the main directly contractile transmitter substance in the urinary bladder, interactions with other transmitters likely occur. Presently, the interplay between purinergic and cholinergic signalling was investigated to unravel the involvement of the urothelium and efferent neurons in the functionally important purinergically evoked release of acetylcholine in …
  • Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs. [Journal Article]
    Pharmaceutics. 2020 Jun 16; 12(6)Hellinen L, Bahrpeyma S, … Urtti A
  • Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissues, such as melanoma. As melanin is present in many pigmented tissues in the human body, investigation of pigment binding is relevant in drug discovery and development. Convention…
  • Carbachol dimers with primary carbamate groups as homobivalent modulators of muscarinic receptors. [Journal Article]
    Eur J Pharmacol. 2020 Jun 10 [Online ahead of print]Matucci R, Bellucci C, … Romanelli MN
  • Although agonists and antagonists of muscarinic receptors have been known for long time, there is renewed interest in compounds (such as allosteric or bitopic ligands, or biased agonists) able to differently and selectively modulate these receptors. As a continuation of our previous research, we designed a new series of dimers of the well-known cholinergic agonist carbachol. The new compounds wer…
  • Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro. [Journal Article]
    Can J Physiol Pharmacol. 2020 Jun 09 [Online ahead of print]Xing H, Xu S, … Han X
  • Levetiracetam(LEV) has been demonstrated to improve cognitive function. Hippocampal theta rhythm (4-12 Hz) is associated with a variety of cognitively related behaviors, such as exploration in both humans and animal models. We investigated the effects of LEV on the theta rhythm in the rat hippocampal CA3 in hippocampal slices in vitro. We found that LEV increased the theta power in a dose-depende…
  • Organophosphorus compounds and oximes: a critical review. [Review]
    Arch Toxicol. 2020 Jun 06 [Online ahead of print]Worek F, Thiermann H, Wille T
  • Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP-inhibited acetylcholinesterase and is virtually unchanged since more than six decades. Established oximes, i.e. pralidoxime, obidoxime, TMB-4, HI-6 …
  • Simultaneous quantification of ergot and tropane alkaloids in bread in the Netherlands by LC-MS/MS. [Journal Article]
    Food Addit Contam Part B Surveill. 2020 Jun 01 [Online ahead of print]Veršilovskis A, Mulder PPJ, … de Nijs M
  • Atropine and scopolamine are tropane alkaloids (TAs), which are regulated for cereal-based foods for children in the EU. For ergot alkaloids (EAs) in cereals and cereal-based food harmonised legislation is not yet established. A fast and straightforward method, which employs extraction by acidified water/methanol followed by ultra-filtration prior to analysis by LC-MS/MS, was validated in bread f…
  • Atropine eye-drop-induced acute delirium: a case report. [Case Reports]
    Gen Psychiatr. 2020; 33(3):e100125.Maravi P, Mishra DK, … Niranjan V
  • Atropine is an anticholinergic drug which is used in both parental and topical routes. Topical eye-drops of atropine sulfate are used as mydriatic and cycloplegics. Parental atropine-induced delirium is well known but topical atropine eye-drop-induced delirium cases are very limited in literature. In this case report, an elderly man underwent cataract surgery and developed delirium after the use …
  • Irinotecan inducing sinus pause bradycardia in a patient with small round cell cancer. [Journal Article]
    BMJ Case Rep. 2020 May 31; 13(5)Mir TA, Yassin AS, … Lohia P
  • Irinotecan is a novel anticancer drug that has worked wonders in combination with other anticancer drugs. It can be used as a single chemotherapy agent in colonic cancer treatment or in combination with 5-fluorouracil. Irinotecan has been found a better salvage therapy in patients who are resistant to 5-fluorouracil. It is also used in combination with cisplatin and other drugs for cancers such a…
  • In vivo paracrine effects of ATP-induced urothelial acetylcholine in the rat urinary bladder. [Journal Article]
    Auton Neurosci. 2020 May 23; 227:102689.Stenqvist J, Aronsson P, … Tobin G
  • Mechanical stretch of the urothelium induces the release of ATP that activates bladder afferent nerves. In the rat urinary bladder, ATP is also a contractile co-transmitter in the parasympathetic innervation. In isolated preparations, ATP evokes a urothelial release of acetylcholine that substantially contributes to ATP-evoked contractile responses. Currently we aimed to further examine the inter…
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