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1,480 results
  • Auranofin inhibits virulence pathways in Pseudomonas aeruginosa. [Journal Article]
    Bioorg Med Chem. 2023 Feb 01; 79:117167.Yam JKH, Tan LZW, … Chng SS
  • Pseudomonas aeruginosa is widely attributed as the leading cause of hospital-acquired infections. Due to intrinsic antibiotic resistance mechanisms and the ability to form biofilms, P. aeruginosa infections are challenging to treat. P. aeruginosa employs multiple virulence mechanisms to establish infections, many of which are controlled by the global virulence regulator Vfr. An attractive strateg…
  • Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria. [Journal Article]
    J Biol Inorg Chem. 2023 Jan 20 [Online ahead of print]Zhang Q, Wang M, … Sun H
  • The emergence and rapid spread of the mobile colistin resistance gene mcr-1 among bacterial species and hosts significantly challenge the efficacy of "last-line" antibiotic colistin. Previously, we reported silver nitrate and auranofin serve as colistin adjuvants for combating mcr-1-positive bacteria. Herein, we uncovered more gold-based drugs and nanoparticles, and found that they exhibited vary…
  • Menadione Potentiates Auranofin-Induced Glioblastoma Cell Death. [Journal Article]
    Int J Mol Sci. 2022 Dec 11; 23(24)Szeliga M, Rola R
  • Glioblastoma (GBM) is the most aggressive primary brain tumor. Recently, agents increasing the level of oxidative stress have been proposed as anticancer drugs. However, their efficacy may be lowered by the cytoprotective activity of antioxidant enzymes, often upregulated in neoplastic cells. Here, we assessed the mRNA and protein expression of thioredoxin reductase 1 (TrxR1), a master regulator …
  • Autophagic checks and balances of cellular immune responses. [Journal Article]
    Autophagy Rep. 2022; 1(1):83-87.Chakravarty S, Fan S, … Chattopadhyay S
  • IRF3 (interferon regulatory factor 3) is a critical component of the antiviral innate immune response. IRF3 deficiency causes detrimental effects to the host during virus infection. Dysregulation of IRF3 functions is associated with viral, inflammatory, and hepatic diseases. Both transcriptional and pro-apoptotic activities of IRF3 are involved in the exacerbated inflammation and apoptosis in liv…
  • Evaluation of Auranofin Loading within Ferritin Nanocages. [Journal Article]
    Int J Mol Sci. 2022 Nov 16; 23(22)Lucignano R, Pratesi A, … Merlino A
  • Auranofin (AF), a gold(I) compound that is currently used for the treatment of rheumatoid arthritis and is in clinical trials for its promising anticancer activity, was encapsulated within the human H-chain and the horse spleen ferritin nanocages using the alkaline disassembly/reassembly protocol. The aim of the work was to highlight possible differences in their drug loading capacity and efficac…
  • Combined Targeting of the Glutathione and Thioredoxin Antioxidant Systems in Pancreatic Cancer. [Journal Article]
    ACS Pharmacol Transl Sci. 2022 Nov 11; 5(11):1070-1078.Fazzari F, Chow S, … Hedley D
  • Pancreatic ductal adenocarcinoma is characterized by increased generation of reactive oxygen species that can cause lethal oxidative stress. Here, we evaluated the combined inhibition of the glutathione and thioredoxin antioxidant systems in preclinical models of pancreatic ductal adenocarcinoma, using buthionine sulfoximine (BSO) that targets glutathione synthesis, and auranofin that targets thi…
  • Protein kinase Cι mediates immunosuppression in lung adenocarcinoma. [Journal Article]
    Sci Transl Med. 2022 11 16; 14(671):eabq5931.Yin N, Liu Y, … Fields AP
  • Lung adenocarcinoma (LUAD) is the most prevalent form of non-small cell lung cancer (NSCLC) and a leading cause of cancer death. Immune checkpoint inhibitors (ICIs) of programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) signaling induce tumor regressions in a subset of LUAD, but many LUAD tumors exhibit resistance to ICI therapy. Here, we identified Prkci as a major determinant of response …
  • Developing Bi-Gold Compound BGC2a to Target Mitochondria for the Elimination of Cancer Cells. [Journal Article]
    Int J Mol Sci. 2022 Oct 12; 23(20)Cui Q, Ding W, … Wen S
  • Reactive oxygen species (ROS) homeostasis and mitochondrial metabolism are critical for the survival of cancer cells, including cancer stem cells (CSCs), which often cause drug resistance and cancer relapse. Auranofin is a mono-gold anti-rheumatic drug, and it has been repurposed as an anticancer agent working by the induction of both ROS increase and mitochondrial dysfunction. Hypothetically, in…
  • Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death. [Journal Article]
    Cancers (Basel). 2022 Oct 05; 14(19)Hatem E, El Banna N, … Huang ME
  • Auranofin (Ridaura®, AUF) is a gold complex originally approved as an antirheumatic agent that has emerged as a potential candidate for multiple repurposed therapies. The best-studied anticancer mechanism of AUF is the inhibition of thioredoxin reductase (TrxR). However, a number of reports indicate a more complex and multifaceted mode of action for AUF that could be cancer cell type- and dose-de…
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