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1,214 results
  • Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma. [Journal Article]
    Redox Biol 2019; 28:101310Sze JH, Raninga PV, … Tonissen KF
  • Multiple myeloma (MM), the second most common haematological malignancy, is a clonal plasma B-cell neoplasm that forms within the bone marrow. Despite recent advancements in treatment, MM remains an incurable disease. Auranofin, a linear gold(I) phosphine compound, has previously been shown to exert a significant anti-myeloma activity by inhibiting thioredoxin reductase (TrxR) activity. A bis-che…
  • Antibiofilm efficacy of the gold compound auranofin on dual-species biofilms of Staphylococcus aureus and Candida spp. [Journal Article]
    J Appl Microbiol 2019She P, Liu Y, … Wu Y
  • CONCLUSIONS: In summary, auranofin could effectively inhibit S. aureus and C. albicans mono and dual biofilm formation in vitro.Coexistence between Staphylococcus aureus and Candida spp. in dual biofilms leads to increased resistance to some conventionally used antimicrobials, indicating a need for alternative treatments. This study demonstrates the potential for the Au-containing compound auranofin in the treatment of dual biofilm infections and encourages further investigation of this treatment for clinical use.
  • Ligand Exchange/Scrambling Study of Gold(I)-Phosphine Complexes in the Solid Phase by DESI-MS Analysis. [Journal Article]
    J Am Soc Mass Spectrom 2019Kazimi SGT, Iqbal MS, … Campbell IS
  • Only a few analytical techniques are available for the characterization of mechanochemical synthetic reaction products. We demonstrate here that DESI-MS is a powerful technique for this purpose, combining the selectivity of MS-based assays with the simplicity and in situ analysis capability of ambient ionization methods. In this work, we report that auranofin, a gold-based drug, and its precursor…
  • Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells. [Journal Article]
    Nat Commun 2019; 10(1):4073Balta E, Hardt R, … Samstag Y
  • Several antitumor therapies work by increasing reactive oxygen species (ROS) within the tumor micromilieu. Here, we reveal that L-plastin (LPL), an established tumor marker, is reversibly regulated by ROS-induced thiol oxidation on Cys101, which forms a disulfide bridge with Cys42. LPL reduction is mediated by the Thioredoxin1 (TRX1) system, as shown by TRX1 trapping, TRX1 knockdown and blockade …
  • Crosslinking Allosteric Sites on the Nucleosome. [Journal Article]
    Angew Chem Int Ed Engl 2019Batchelor LK, De Falco L, … Dyson PJ
  • Targeting defined histone protein sites in chromatin is an emerging therapeutic approach that can potentially be enhanced by allosteric effects within the nucleosome. Here we characterized a novel hetero-bimetallic compound with a design based on a nucleosomal allostery effect observed earlier for two unrelated drugs- the Ru(II) antimetastasis/antitumour RAPTA-T and the Au(I) anti-arthritic auran…
  • The leading established metal-based drugs: a revisitation of their relevant physico-chemical data. [Journal Article]
    Biometals 2019Cirri D, Fabbrini MG, … Messori L
  • The study of metal-based drugs represents an important branch of modern bioinorganic chemistry. The growing importance of this field is linked to the large success in medicine of a few metal based drugs, either in clinical use or still experimental. Moreover, these metal-based drugs are frequently used as reference compounds to assess comparatively the behavior of newly synthesized metallodrugs. …
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