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1,692 results
  • Menadione Potentiates Auranofin-Induced Glioblastoma Cell Death. [Journal Article]
    Int J Mol Sci. 2022 Dec 11; 23(24)Szeliga M, Rola R
  • Glioblastoma (GBM) is the most aggressive primary brain tumor. Recently, agents increasing the level of oxidative stress have been proposed as anticancer drugs. However, their efficacy may be lowered by the cytoprotective activity of antioxidant enzymes, often upregulated in neoplastic cells. Here, we assessed the mRNA and protein expression of thioredoxin reductase 1 (TrxR1), a master regulator …
  • Evaluation of Auranofin Loading within Ferritin Nanocages. [Journal Article]
    Int J Mol Sci. 2022 Nov 16; 23(22)Lucignano R, Pratesi A, … Merlino A
  • Auranofin (AF), a gold(I) compound that is currently used for the treatment of rheumatoid arthritis and is in clinical trials for its promising anticancer activity, was encapsulated within the human H-chain and the horse spleen ferritin nanocages using the alkaline disassembly/reassembly protocol. The aim of the work was to highlight possible differences in their drug loading capacity and efficac…
  • Developing Bi-Gold Compound BGC2a to Target Mitochondria for the Elimination of Cancer Cells. [Journal Article]
    Int J Mol Sci. 2022 Oct 12; 23(20)Cui Q, Ding W, … Wen S
  • Reactive oxygen species (ROS) homeostasis and mitochondrial metabolism are critical for the survival of cancer cells, including cancer stem cells (CSCs), which often cause drug resistance and cancer relapse. Auranofin is a mono-gold anti-rheumatic drug, and it has been repurposed as an anticancer agent working by the induction of both ROS increase and mitochondrial dysfunction. Hypothetically, in…
  • Efficacy of auranofin as an inhibitor of desmoid progression. [Journal Article]
    Sci Rep. 2022 07 13; 12(1):11918.Ito K, Nishida Y, … Imagama S
  • Anticancer drugs and molecular targeted therapies are used for refractory desmoid-type fibromatosis (DF), but occasionally cause severe side effects. The purpose of this study was to identify an effective drug with fewer side effects against DF by drug repositioning, and evaluate its efficacy. FDA-approved drugs that inhibit the proliferation of DF cells harboring S45F mutations of CTNNB1 were sc…
  • Bringing the Spotlight to Tau and TDP-43 in Frontotemporal Dementia: A Review of Promising Chemical Compounds. [Review]
    Curr Med Chem. 2022; 29(38):5903-5924.Villalobos-Nova K, Monroy-Moya S, … Cornejo A
  • There is a wide variety of neurodegenerative diseases, among which frontotemporal dementia stands out. These are the second most frequent cause of dementia in the world and demand the search for an effective treatment. This disease is linked to the abnormal behavior of proteins, which group together to form insoluble aggregates. It has been shown that the tau protein and TDP-43 are the main prote…
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