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47 results
  • Autosplenectomy in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH). [Case Reports]
    Case Rep Hematol 2019; 2019:3146965Burns E, Anand K, … Rice L
  • Autosplenectomy (AS) is a known complication of diseases such as sickle cell anemia, celiac disease, and inflammatory bowel disease. We report the first known case of AS due to paroxysmal nocturnal hemoglobinuria (PNH). A 24-year-old Caucasian male had evidence of hemolytic anemia at the age of 14 and was diagnosed with PNH at the age of 16. He had recurrent episodes of sepsis due to dialysis lin…
  • Inflammation in sickle cell disease. [Journal Article]
    Clin Hemorheol Microcirc 2018; 68(2-3):263-299Conran N, Belcher JD
  • The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant pathophysiological consequences that result in hemolytic events and the induction of the inflammatory processes that ultimately lead to vaso-occlusion. In addition to their role in the initiation of the acute painful vaso-occlusive episodes that are characteristic of SCD, inflammatory processes are also key c…
  • A Case of Autosplenectomy in Sickle Cell Trait Following an Exposure to High Altitude. [Case Reports]
    Wilderness Environ Med 2018; 29(1):85-89Yanamandra U, Das R, … Varma S
  • A 24-year-old man presented with acute abdominal pain upon ascent to moderate altitude (3500 m). An immediate evaluation revealed a splenic infarct, and he was evacuated to sea level. Upon recovery, he was sent back to 3500 m without detailed etiological evaluation, whereupon he experienced recurrent episodes of left-side subcostal pain. Imaging suggested autosplenectomy, and workup revealed a ne…
  • The case of the mysterious vanishing spleen: autosplenectomy complicating pneumococcal sepsis. [Case Reports]
    BMJ Case Rep 2017; 2017Moritz G, Jenkins M, … Blundell J
  • A 57-year-old previously healthy fisherman was admitted in fulminant pneumococcal septic shock, with disseminated intravascular coagulation, requiring aggressive management including bilateral below-knee amputations for ischaemic necrosis. He began to recover and was discharged for rehabilitation, however during his convalescence was found to be hypercalcaemic. No malignancy was found on CT scan,…
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