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7,053 results
  • Germline DDX41 mutations define a significant entity within adult MDS/AML patients. [Journal Article]
    Blood 2019Sébert M, Passet M, … Clappier E
  • Germline DDX41 mutations are involved in familial myelodysplastic syndromes (MDS) and acute myeloid leukemias (AML). We analyzed the prevalence and characteristics of DDX41-related myeloid malignancies in an unselected cohort of 1385 patients with MDS or AML. Using targeted next-generation sequencing, we identified 28 different germline DDX41 variants in 43 unrelated patients which we classified …
  • New drugs approved for acute myeloid leukemia (AML) in 2018. [Review]
    Br J Clin Pharmacol 2019Kucukyurt S, Eskazan AE
  • Acute myeloid leukemia (AML) is a hematopoietic stem cell disorder, that is characterized by the clonal expansion of myeloid blasts and suppression of normal hematopoiesis. The 3+7 regimen is the backbone of standard first-line induction therapy among young/fit patients. However, in elderly and/or unfit patients with newly diagnosed AML, who cannot receive intensive chemotherapy, low-dose cytarab…
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