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Unbound Medicine.
(azatadine)
77 results
  • Drugs and Lactation Database (LactMed): Azatadine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Small occasional doses of azatadine are probably acceptable during breastfeeding. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. The nonsedating antihistamines are preferred alternatives.
  • Report: A comparative study of loratidine physiochemical properties from different brands. [Journal Article]
    Pak J Pharm Sci. 2018 Nov; 31(6):2569-2574.Naveed S, Dilshad H
  • Loratidine is a piperidine derivative resemble to azatadine long acting non sedating commonly used for the treatment of allergic condition like watery or itchy eyes, runny nose, chronic urticaria or throat itching. In the present study different brands of loratidine were evaluated for the weight variation, hardness, friability, disintegration time and dissolution. Dissolution release study perfor…
  • Determination of azatadine in human plasma by liquid chromatography/tandem mass spectrometry. [Journal Article]
    J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Aug 01; 879(23):2189-93.Zhu YR, Jia YY, … Wen AD
  • A sensitive method using liquid chromatography with tandem mass spectrometric detection (LC-MS/MS) was developed and validated for the analysis of antihistamine drug azatadine in human plasma. Loratadine was used as internal standard (IS). Analytes were extracted from human plasma by liquid/liquid extraction using ethyl acetate. The organic phase was reduced to dryness under a stream of nitrogen …
  • Antiallergic anti-inflammatory effects of H1-antihistamines in humans. [Review]
    Clin Allergy Immunol. 2002; 17:101-39.Assanasen P, Naclerio RM
  • Data from in vitro, in vivo, and ex vivo studies suggest that second-generation antihistamines have a number of antiallergic, anti-inflammatory properties that appear to be independent of their H1-blockade activity. First-generation antihistamines also have antiallergic, anti-inflammatory properties, as suggested by the studies with azatadine, chlorpheniramine, mepyramine, and promethazine; most …
  • Antiallergic effects of H1-receptor antagonists. [Review]
    Allergy. 2000; 55 Suppl 64:17-27.Baroody FM, Naclerio RM
  • The primary mechanism of antihistamine action in the treatment of allergic diseases is believed to be competitive antagonism of histamine binding to cellular receptors (specifically, the H1-receptors), which are present on nerve endings, smooth muscles, and glandular cells. This notion is supported by the fact that structurally unrelated drugs antagonize the H1-receptor and provide clinical benef…
  • Hydroxyzine inhibits neurogenic bladder mast cell activation. [Journal Article]
    Int J Immunopharmacol. 1998 Oct; 20(10):553-63.Minogiannis P, El-Mansoury M, … Theoharides TC
  • CONCLUSIONS: Hydroxyzine reduced carbachol-induced serotonin release from rat bladder in vitro through a mechanism which was unrelated to its H-1 receptor antagonistic properties. The ability of hydroxyzine to inhibit bladder mast cell activation by neurogenic stimuli along with its anticholinergic, anxiolytic and analgesic properties, may explain the clinical efficacy of this drug in reducing IC symptoms. Other, nonsedating, hydroxyzine analogues able to inhibit bladder mast cell activation may provide potentially new therapeutic approaches for IC.
  • Fungal biotransformation of the antihistamine azatadine by Cunninghamella elegans. [Journal Article]
    Appl Environ Microbiol. 1996 Sep; 62(9):3477-9.Zhang D, Hansen EB, … Cerniglia CE
  • The metabolism of the antihistamine azatadine by the zygomycete fungus Cunninghamella elegans ATCC 9245 was investigated. Within 72 h from the addition of the drug to 48-h-old cultures grown in Sabouraud dextrose broth, 95% of azatadine was biotransformed. Two major metabolites, 7-hydroxyazatadine (25%) and 8-hydroxyazatadine (50%), and two minor metabolites, N-desmethylazatadine and 9-hydroxyaza…
  • An algorithmic approach to chronic cough. [Journal Article]
    Ann Intern Med. 1993 Nov 15; 119(10):977-83.Pratter MR, Bartter T, … DuBois J
  • CONCLUSIONS: A sequential approach to chronic cough that emphasizes initial treatment with an antihistamine-decongestant is effective. Bronchoprovocation challenge is useful in evaluating patients with chronic cough but can be delayed until the initial response to antihistamine-decongestant therapy has been assessed. The 18% incidence of recurrence highlights the fact that cough often is the manifestation of a chronic or recurring process that requires chronic or episodic therapy.
  • Chloroquine-potentiating action of antihistaminics in Plasmodium falciparum in vitro. [Journal Article]
    Ann Trop Med Parasitol. 1991 Apr; 85(2):223-8.Basco LK, Ringwald P, Le Bras J
  • Tricyclic antihistaminics have relatively few side-effects compared to other agents that enhance the susceptibility to chloroquine of chloroquine-resistant strains of Plasmodium falciparum. Their efficacy was tested in vitro against resistant and sensitive culture-adapted strains of P. falciparum. Isobologram analysis showed that both cyproheptadine and azatadine exert a marked synergistic action…
  • The effects of antihistamines beyond H1 antagonism in allergic inflammation. [Randomized Controlled Trial]
    J Allergy Clin Immunol. 1990 Dec; 86(6 Pt 2):1019-24.Massey WA, Lichtenstein LM
  • Antigen and cold dry air were used to challenge the upper and lower airways, skin, and conjunctiva. In each of these four systems an immediate and late-phase reaction to antigen is well characterized. Although the pattern of mediator release is different in these four areas, the degree of infiltration of basophils and eosinophils in the late-phase reaction appears to be constant. Of a number of d…
  • Nonsedating histamine H1-receptor antagonists. [Review]
    Clin Pharm. 1989 May; 8(5):331-44.Mann KV, Crowe JP, Tietze KJ
  • The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosages of the nonsedating histamine H1-receptor antagonists terfenadine, astemizole, loratadine, and acrivastine are reviewed. Terfenadine and astemizole are chemically unrelated to histamine H1-receptor antagonists such as diphenhydramine and chlorpheniramine. Loratadine is structurally related to the antihis…
  • Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy. [Review]
    Drugs. 1989 Jan; 37(1):42-57.Clissold SP, Sorkin EM, Goa KL
  • Loratadine is a long acting antihistamine which has a high selectivity for peripheral histamine H1-receptors and lacks the central nervous system depressant effects often associated with some of the older antihistamines. Results from controlled clinical trials have shown that loratadine (usually 10mg once daily) is a well-tolerated and effective antihistamine which will be beneficial in patients …
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