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13,089 results
  • Antiretroviral Levels in the Cerebrospinal Fluid: The Effect of Inflammation and Genetic Variants. [Journal Article]
    Diagnostics (Basel). 2023 Jan 12; 13(2)Cusato J, Avataneo V, … Calcagno A
  • Neurocognitive impairments are common in people living with HIV. Some conditions, such as chronic inflammation, astrocyte infection and an impaired blood-brain barrier (BBBi), along with host genetic variants in transporter genes, may affect antiretroviral (ARV) exposure in the cerebrospinal fluid (CSF). The aim of this study was to evaluate ARV CSF penetration according to compartmental inflamma…
  • Drugs and Lactation Database (LactMed): Zidovudine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Zidovudine has been well studied during breastfeeding. Milk levels are low and most breastfed infants do not have detectable blood levels. Some breastfed infants have developed anemia during maternal therapy.
  • Anti-ageing effects of FDA-approved medicines: a focused review. [Review]
    J Basic Clin Physiol Pharmacol. 2023 Jan 13 [Online ahead of print]Thanapairoje K, Junsiritrakhoon S, … Supharattanasitthi W
  • Ageing is the process generated by senescent cells, free radicals, inflammation and other relevant factors. Ageing contributes to age-related diseases that affect the quality of life. People are interested in anti-ageing intervention and many scientists attempt to search for anti-ageing medicines. This review focused on describing in vivo anti-ageing activity of US-FDA-approved drugs and found th…
  • The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy. [Review]
    Molecules. 2022 Dec 03; 27(23)Bianco MDCAD, Inacio Leite D, … Bastos MM
  • The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug). A polypharmacology approach is widely applied in the treatment of acquired immunodeficiency syndrome (AIDS), providing life-saving therapies for millions of people living wit…
  • StatPearls: Zidovudine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EdwardsZacharyZCampbell University School of Osteopathic MedicineIngoldCurtis J.CJUniversity HospitalsAzmatChaudhary EhtshamCERawalpindi Medical College and Allied HospitalsBOOK
  • Zidovudine is a medication used in the management and treatment of HIV-1. It is in the nucleoside reverse transcriptase inhibitor class of medications. This activity reviews the indications, mechanism of action, and contraindications for zidovudine as a valuable agent in the treatment of HIV-1. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Antiviral Agents [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The antivirals are a large and diverse group of agents that are typically classified by the virus infections for which they are used, their chemical structure and their mode of action. Most antiviral agents have been developed in the last 20 to 25 years, many as a result of the major research efforts to develop therapies and means of prevention of human immunodeficiency virus (HIV) infection and …
  • In Situ Super-Resolution Imaging of Telomeres with DNA-PAINT. [Journal Article]
    ACS Omega. 2022 Nov 08; 7(44):40512-40519.Liu Y, Ye X, … Cui Y
  • Telomeres are located at the ends of chromosomes and play an important role in maintaining the integrity of chromosomes and controlling the cycle of cell division. Studies have shown that abnormal telomere length may lead to the occurrence of some diseases. Therefore, accurate measurement of telomere length will be helpful for the prediction and diagnosis of related diseases. DNA point accumulati…
  • Parvovirus Infection Leading to Severe Anemia in an Adult Patient With HIV Disease. [Case Reports]
    Cureus. 2022 Sep; 14(9):e29148.Tun MM, Chowdhury T, … Htet SY
  • Individuals with human immunodeficiency virus (HIV) disease frequently suffer from anemia. The causes include anemia of chronic disease, vitamin B12 and iron deficiency, opportunistic infections (Mycobacterium tuberculosis, Pneumocystis jiroveci), HIV-related bone marrow suppression, AIDS-associated malignancies, and antiretroviral therapy (ART), specifically zidovudine. In HIV patients with adva…
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