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7,827 results
  • Guidelines for the treatment of dysentery (shigellosis): a systematic review of the evidence. [Journal Article]
  • PIPaediatr Int Child Health 2018; 38(sup1):S50-S65
  • Williams PCM, Berkley JA
  • CONCLUSIONS: Current WHO guidelines support the use of fluoroquinolones (first-line), β-lactams (second-line) and cephalosporins (second-line) which accords with currently available evidence and other international guidelines, and there is no strong evidence for changing this guidance. Azithromycin is appropriate as a second-line therapy in regions where the rate of non-susceptibility of ciprofloxacin is known to be high, and research suggests that, from a cardiac point of view, azithromycin is safer than other macrolide antibiotics. Cefixime is also a reasonable alternative, although its use must be weighed against the risk of dissemination of extended-spectrum β-lactamase-producing organisms.
  • What are Canadian primary care physicians prescribing for the treatment of gonorrhea? [Journal Article]
  • CCCan Commun Dis Rep 2017 Feb 02; 43(2):33-37
  • Ha S, Pogany L, … Gale-Rowe M
  • CONCLUSIONS: This convenience sample suggests that although knowledge of pharmaceutical management, partner notification, and public health reporting is high, the use of combination therapy to deter the development of antimicrobial resistant gonorrhea may not be widespread among primary care physicians. In light of both the growing incidence of N. gonorrhea and the rising rates of antimicrobial resistance in Canada, consideration on how to improve awareness and update of best prescribing practices in primary care may be indicated.
  • Antimicrobial resistance to Neisseria gonorrhoeae in Canada: 2009-2013. [Journal Article]
  • CCCan Commun Dis Rep 2015 Feb 05; 41(2):35-41
  • Martin I, Sawatzky P, … Mulvey MR
  • CONCLUSIONS: Resistance to erythromycin, penicillin, tetracycline and ciprofloxacin is common. Decreased susceptibility to ceftriaxone and/or cefixime is now almost 4% and azithromycin resistance is emerging but remains low at 1.2%. These results have informed the gonococcal infection treatment recommendations in the Canadian Guidelines on Sexually Transmitted Infections.
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