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(basal ganglion)
114,970 results
  • Unusual cause of treatable Parkinsonism. [Journal Article]
    Pract Neurol 2019Wiblin L, Mitra D, Warren N
  • A 78-year-old woman presented with features of bilateral, asymmetric Parkinsonism for 1 year, with prominent difficulties with continence, swallowing and apathy. Brain imaging showed evidence of chronic venous sinus thrombosis with dilated serpiginous vessels over the brain surface in keeping with a dural arteriovenous fistula, together with high T2 signal on MRI in the basal ganglia. Having resp…
  • Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons. [Journal Article]
    J Physiol 2019Krajeski RN, Macey-Dare A, … Ellender TJ
  • CONCLUSIONS: Imbalances in the activity of the D1-expressing direct-pathway and D2-expressing indirect-pathway striatal projection neurons (SPNs) are thought to contribute to many basal ganglia disorders, including early-onset neurodevelopmental disorders such as OCD, ADHD and Tourette's syndrome. This study provides the first detailed quantitative investigation of D1 and D2 SPN development, including their cellular properties and connectivity within neural circuits, during the first postnatal weeks. This period is highly dynamic with many properties changing, but it is possible to make three main observations. Firstly, that many aspects of D1 and D2 SPNs progressively mature in parallel. Secondly, that there are notable exceptions when they diverge. Thirdly, that many of the defining properties of mature striatal SPNs and circuits are already established by the first and second postnatal weeks, suggesting guidance through intrinsic developmental programs. These findings provide an experimental framework for future studies of striatal development in both health and disease.
  • A Cortico- Basal Ganglia Model for choosing an optimal rehabilitation strategy in Hemiparetic Stroke. [Journal Article]
    Sci Rep 2019; 9(1):13472Narayanamurthy R, Jayakumar S, … Chakravarthy VS
  • To facilitate the selection of an optimal therapy for a stroke patient with upper extremity hemiparesis, we propose a cortico-basal ganglia model capable of performing reaching tasks under normal and stroke conditions. The model contains two hemispherical systems, each organized into an outer sensory-motor cortical loop and an inner basal ganglia (BG) loop, controlling their respective hands. The…
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