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4,133 results
  • Serum cytokine, chemokine, and growth factor profiles and their modulation in inflammatory bowel disease. [Journal Article]
    Medicine (Baltimore) 2019; 98(38):e17208Martinez-Fierro ML, Garza-Veloz I, … Ortiz-Castro Y
  • Ulcerative colitis (UC) and Crohn disease (CD) are the most common forms of inflammatory bowel disease (IBD). Because these subtypes of IBD are characterized by periods of activity and remission, an understanding of the modulation of biochemical markers with the clinical features of IBD or its treatment, may be useful for determining the correct treatment protocol.This study aimed to evaluate the…
  • Twiner: correlation-based regularization for identifying common cancer gene signatures. [Journal Article]
    BMC Bioinformatics 2019; 20(1):356Lopes MB, Casimiro S, Vinga S
  • CONCLUSIONS: Our analysis led to the identification of genes that show a similar correlation pattern in BRCA and PRAD transcriptomic data, and are selected as key players in the classification of breast and prostate samples into ER+ BRCA/AR+ TNBC/PRAD tumor and normal tissues, and also associated with survival time distributions. The results obtained are supported by the literature and are expected to unveil the similarities between the diseases, disclose common disease biomarkers, and help in the definition of new strategies for more effective therapies.
  • A health needs assessment of adults with diabetic foot disease in the US. [Journal Article]
    Diabetes Metab Syndr 2019 May - Jun; 13(3):2152-2157Shi H
  • Diabetic foot disease has been considered as an important complication of diabetes mellitus. The main risk factor to cause diabetic foot disease is peripheral neuropathy. Diabetic foot disease usually started from diabetic foot ulceration, it would develop to diabetic foot infection and amputation even death when conducting the poor prognosis and management of diabetic foot ulceration. Despite th…
  • Proximity hybridization-induced on particle DNA walker for ultrasensitive protein detection. [Journal Article]
    Anal Chim Acta 2019; 1074:142-149Gan H, Wu J, Ju H
  • A simple proximity hybridization-induced on particle DNA walker was designed for ultrasensitive detection of proteins, for example platelet-derived growth factor (PDGF-BB) secreted by cancer cells, in which the DNA walker was activated by specific target binding and powered by an enzymatic cleavage to produce amplified signal. High-density FAM-labeled hairpin oligonucleotides (FAM-DNA1) were func…
  • Pericytes in Primary Familial Brain Calcification. [Review]
    Adv Exp Med Biol 2019; 1147:247-264Zarb Y, Franzoso FD, Keller A
  • Pericytes are perivascular cells along capillaries that are critical for the development of a functional vascular bed in the central nervous system and other organs. Pericyte functions in the adult brain are less well understood. Pericytes have been suggested to mediate functional hyperemia at the capillary level, regulate the blood-brain barrier and to give rise to scar tissue after spinal cord …
  • Advancing pharmacotherapy for diabetic foot ulcers. [Review]
    Expert Opin Pharmacother 2019; 20(9):1153-1160Eleftheriadou I, Tentolouris A, … Papanas N
  • Standard treatment for diabetic foot ulcers (DFUs) includes off-loading, debridement, moisture balance, management of infection and peripheral arterial disease (PAD) as well as adequate glycemic control. The outcomes so far are unsatisfactory.
  • Influence of drugs on the prospective diagnostic method for coronary heart disease with urine. [Journal Article]
    Spectrochim Acta A Mol Biomol Spectrosc 2019; 217:176-181Yang H, Luo C, … Cai X
  • The morbidity of coronary heart disease (CHD) with high risks has been rising in recent years. A novel and noninvasive method based on surface-enhanced Raman spectroscopy (SERS) was proposed by Yang et al. (Analyst 143: 2235, 2018) to prospectively diagnose the arterial blockage by detecting platelet-derived growth factor-BB (PDGF-BB) in urine. Clinically, anti-platelet drugs (such as aspirin, st…
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