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(benznidazole)
1,342 results
  • Trypanocidal Trixikingolides From Trixis Vauthieri. [Journal Article]
    Nat Prod Res 2019; :1-9Sales Junior PA, Zani CL, … Alves TMA
  • Chagas disease is an illness caused by the protozoan parasite Trypanosoma cruzi. Only two drugs are available, with the drawback of low rate of cure in the chronic phase of the disease and undesirable side effects. These facts highlight the need to find new compounds for Chagas disease chemotherapy. We describe the isolation and identification of an inseparable mixture of two new trixikingolides …
  • Antiprotozoal alkaloid principles of the plant family Amaryllidaceae. [Review]
    Bioorg Med Chem Lett 2019; 29(20):126642Nair JJ, van Staden J
  • Protozoan-borne diseases are prominent amongst diseases caused by parasites. Given their alarming morbidity and mortality statistics, there is ever growing interest in new therapies against these diseases. Whilst synthetic drugs such as benznidazole and melarsoprol have had a profound influence on the clinical setup, there has been significant interest in the phytochemical platform to also delive…
  • Hybrids of Cinchona Alkaloids and Bile Acids as Antiparasitic Agents Against Trypanosoma cruzi. [Journal Article]
    Molecules 2019; 24(17)Musikant D, Leverrier A, … Edreira MM
  • The current chemotherapy of Chagas disease needs to be urgently improved. With this aim, a series of 16 hybrids of Cinchona alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus by a radical attack of a norcholane substituent via a Barton-Zard decarboxylation reaction. The antitrypanosomal activity of the hybrids was tested on different stages and st…
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