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991 results
  • Acute dystonic reaction induced by a single dose of clebopride: A case report. [Case Reports]
    Medicine (Baltimore) 2019; 98(22):e15826Seo YW, Ko SH, … Kim GM
  • CONCLUSIONS: Although it is uncommon to experience extrapyramidal symptoms by clebopride, its chemical closeness to metoclopramide may induce such symptoms under certain clinical situations. Therefore, physicians should take in consideration of this effect and dwell in caution upon prescribing the drug.
  • Psychotropics in Your Medicine Cabinet: A Case Study of Dimenhydrinate Use. [Journal Article]
    J Addict Med 2019Wen X, Di Paola F, Chopra N
  • : Reporting of intoxication and withdrawal from aberrant use of over-the-counter medication has been sparse and inconsistent in literature. Attributed to their anticholinergic properties, medications such as dimenhydrinate (Gravol) taken in supratherapeutic doses have been associated with euphoria, anxiolysis, and hallucinations. We present a case of a woman in her forties, with a psychiatric his…
  • Lithium: contributor to movement disorder sensitivity after anoxic brain injury? [Case Reports]
    SAGE Open Med Case Rep 2019; 7:2050313X18823101Pikard JL, Oliver D, … Groll D
  • Although lithium-induced dystonia has been well documented in the literature, conflicting evidence discusses whether a patient may be susceptible to adverse effects from the drug after an anoxic brain injury. More recent literature discusses that lithium may, in fact, be neuroprotective. This case report presents a 35-year-old male who, after an anoxic brain injury after a suicide attempt, develo…
  • Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth. [Journal Article]
    Acta Neuropathol Commun 2019; 7(1):9Cerles O, Gonçalves TC, … Batteux F
  • The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are widely used as part of first line conventional cancer chemotherapy; their efficacy is however limited by peripheral neuropathy as a major side-effect. In a multiple sclerosis mouse model, benztropine, that a…
  • Tuftsin Combines With Remyelinating Therapy and Improves Outcomes in Models of CNS Demyelinating Disease. [Journal Article]
    Front Immunol 2018; 9:2784Thompson KK, Nissen JC, … Tsirka SE
  • Though promoting remyelination in multiple sclerosis (MS) has emerged as a promising therapeutic strategy, it does not address inflammatory signals that continue to induce neuronal damage and inhibit effectiveness of repair mechanisms. Our lab has previously characterized the immunomodulatory tetrapeptide, tuftsin, which induces an anti-inflammatory shift in microglia and macrophages. This target…
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