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961 results
  • Public Health Aspects in the Prevention and Control of Vitamin Deficiencies. [Review]
    Curr Dev Nutr 2019; 3(9):nzz075Darnton-Hill I
  • Vitamin deficiencies remain major etiological factors in the global burden of disease, especially in low- and middle-income countries. The purpose of this state-of-the-art review was to update current information on deficiencies of vitamins and public health approaches to addressing them. Some stages of life present a higher risk of deficiency than others: risks are higher in pregnant women, chil…
  • Gastrointestinal Beriberi and Wernicke's Encephalopathy Triggered by One Session of Heavy Drinking. [Case Reports]
    Case Rep Neurol 2019 Jan-Apr; 11(1):124-131Tjong E, Peng YY
  • An otherwise healthy 30-year-old male acquired gastrointestinal beriberi and subsequent Wernicke's encephalopathy after 1 session of heavy drinking. Nausea, vomiting, and anorexia relentlessly progressed. The patient developed external ophthalmoplegia after 2 months. Intravenous 1,000 mg thiamine reversed both neurologic and gastrointestinal symptoms within hours. It is hard to diagnose gastroint…
  • Thiamine Deficiency in a Nondrinker and Secondary Pulmonary Edema after Thiamine Replenishment. [Journal Article]
    Intern Med 2019Nakamura H, Utsunomiya A, … Horita T
  • A 48-year-old man was brought to our emergency room with acute abdominal pain and systemic edema, indicating acute circulatory failure with lactic acidosis. Furosemide treatment paradoxically worsened the systemic edema and induced confusion. He had no drinking history but hardly ate legumes or meats containing thiamine. Administration of fursultiamine dramatically improved the symptoms and subse…
  • The In Vivo and In Vitro Toxicokinetics of Citreoviridin Extracted from Penicillium citreonigrum. [Journal Article]
    Toxins (Basel) 2019; 11(6)Uchiyama Y, Takino M, … Sugita-Konishi Y
  • Citreoviridin (CTVD), a mycotoxin called yellow rice toxin, is reported to be related to acute cardiac beriberi; however, its toxicokinetics remain unclear. The present study elucidated the toxicokinetics through in vivo experiments in swine and predicted the human toxicokinetics by comparing the findings to those from in vitro experiments. In vivo experiments revealed the high bioavailability of…
  • Thiamine and Heart Failure: Challenging Cases of Modern-Day Cardiac Beriberi. [Case Reports]
    Mayo Clin Proc Innov Qual Outcomes 2019; 3(2):221-225Helali J, Park S, … Lankarani-Fard A
  • Cardiac beriberi, or heart failure due to thiamine deficiency, is considered rare in the developed world. The diagnosis is often only considered in limited populations such as those with chronic alcoholism. Alternatively, the disease can be mislabeled as "alcoholic cardiomyopathy" or "nonischemic cardiomyopathy." The following 2 cases illustrate the need to expand our vigilance to other at-risk p…
  • Possible involvement of thiamine insufficiency in heart failure in the institutionalized elderly. [Journal Article]
    J Clin Biochem Nutr 2019; 64(3):239-242Ao M, Yamamoto K, … Tanaka K
  • Heart failure is a major manifestation of thiamine deficiency; beriberi. Even thiamine insufficiency, milder than deficiency, may be associated with increased heart failure risk. In this cross-sectional study, the relationship between thiamine insufficiency and heart failure was investigated in the Japanese institutionalized elderly from April to November 2017. Fifty-five subjects in four care fa…
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