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203,626 results
  • Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis. [Review]
  • APAnn Phys Rehabil Med 2019 May 20
  • Goh SL, Persson MS, … Zhang W
  • CONCLUSIONS: Exercise significantly reduces pain and improves function, performance and QoL in people with knee and hip OA as compared with usual care at 8 weeks. The effects are maximal around 2 months and thereafter slowly diminish, being no better than usual care at 9 to 18 months. Participants with younger age, knee OA and not awaiting joint replacement may benefit more from exercise therapy. These potential determinants, identified by study-level analyses, may have implied ecological bias and need to be confirmed with individual patient data.
  • Prevalence of trial registration varies by study characteristics and risk of bias. [Review]
  • JCJ Clin Epidemiol 2019 May 20
  • Tan AC, Jiang I, … Seidler AL
  • CONCLUSIONS: Trial registration is an imperfect proxy for risk of bias. Systematic reviewers should assess risk of bias on a case-by-case basis and conduct sensitivity analyses excluding high risk of bias studies. In the longer term, mechanisms should be implemented to facilitate prospective registration of all trials.
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