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(bioassay)
144,990 results
  • One for All: A Pooled Approach to Classify Functional Impacts of Multiple Mutations. [Journal Article]
    Cell Stem Cell. 2020 Jul 02; 27(1):1-3.Jourdon A, Vaccarino FM
  • Understanding common biological consequences of heterogenous mutations in complex polygenic conditions is challenging. In this issue of Cell Stem Cell, Cederquist et al. (2020) implement an in vitro pooled assay where 30 high-confidence ASD mutations engineered in subclones of a human pluripotent stem cell line can be investigated in parallel to reveal their effects on prefrontal cortex neurogene…
  • Genetic structure and insecticide resistance characteristics of fall armyworm populations invading China. [Journal Article]
    Mol Ecol Resour. 2020 Jul 03 [Online ahead of print]Zhang L, Liu B, … Xiao Y
  • The rapid wide-scale spread of fall armyworm (Spodoptera frugiperda) has caused serious crop losses globally. However, differences in the genetic background of subpopulations and the mechanisms of rapid adaptation behind the invasion are still not well understood. Here we report the assembly of a 390.38Mb chromosome-level genome of fall armyworm derived from south-central Africa using Pacific Bio…
  • Genome-wide identification and expression profiling of the YUCCA gene family in Malus domestica. [Journal Article]
    Sci Rep. 2020 Jul 02; 10(1):10866.Song C, Zhang D, … An N
  • The plant hormone auxin is essential for plant growth and development. YUCCA proteins catalyse the rate-limiting step for endogenous auxin biosynthesis. In this study, we isolated 20 MdYUCCA genes from apple genome. MdYUCCA6a, MdYUCCA8a, and MdYUCCA10a were expressed in most organs and could support whole plant basal auxin synthesis. MdYUCCA4a, MdYUCCA10b, and MdYUCCA11a expression indicated role…
  • Multi-Task Learning Models for Predicting Active Compounds. [Journal Article]
    J Biomed Inform. 2020 Jun 29 [Online ahead of print]Zhao Z, Qin J, … Yang Y
  • The computational drug discovery methods can find potential drug-target interactions more efficiently and have been widely studied over past few decades. Such methods explore the relationship between the structural properties of compounds and their biological activity with the assumption that similar compounds tend to share similar biological targets and vice versa. However, traditional Quantitat…
  • A new method for identification of outliers in immunogenicity assay cut point data. [Journal Article]
    J Immunol Methods. 2020 Jun 29 [Online ahead of print]Zhang J, Arends R, … Yang H
  • The cut point is an important parameter for immunogenicity assay validation and critical to immunogenicity assessment in clinical trials. FDA (2019) recommends using a statistical approach to derive cut point, with an appropriate outlier removal procedure. In general, the industry follows the methods described in Shankar et al. (2008) and Zhang et al. (2013) to determine cut point. Outlier remova…
  • Precipitation-based colorimetric multiplex immunoassay in hydrogel particles. [Journal Article]
    Lab Chip. 2020 Jul 02 [Online ahead of print]Roh YH, Lee HJ, … Bong KW
  • Despite a growing demand for more accessible diagnostic technologies, current methods struggle to simultaneously detect multiple analytes with acceptable sensitivity and portability. Colorimetric assays have been widely used due to their simplicity of signal readout, but the lack of multiplexibility has been a perpetual constraint. Meanwhile, particle-based assays offer multiplex detection by ass…
  • Chemical, biological and in silico assessment of Ocimum viride essential oil. [Journal Article]
    Heliyon. 2020 Jun; 6(6):e04209.Bhagat M, Sangral M, … Arya K
  • Ocimum viride Willd. (family: Lamiaceae) is a member of the genus Ocimum, an aromatic annual and perennial herb with numerous culinary, horticultural and ethno-medicinal benefits. This study aims to explore the chemical properties of leaf essential oil (EO) from Ocimum viride and to evaluate its antimicrobial and anticancer potential.
  • Telomere Length Measurement by Molecular Combing. [Journal Article]
    Front Cell Dev Biol. 2020; 8:493.Kahl VFS, Allen JAM, … Pickett HA
  • Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks. Telomeric DNA is gradually eroded with each round of cell division, resulting in the accumulation of critically short or dysfunctional telomeres that eventually trigger cellular senescence. Consequent…
  • An ultra-sensitive and easy-to-use assay for sensing human UGT1A1 activities in biological systems. [Journal Article]
    J Pharm Anal. 2020 Jun; 10(3):263-270.Zhu YD, Pang HL, … Ge GB
  • The human UDP-glucuronosyltransferase 1A1 (UGT1A1), one of the most essential conjugative enzymes, is responsible for the metabolism and detoxification of bilirubin and other endogenous substances, as well as many different xenobiotic compounds. Deciphering UGT1A1 relevance to human diseases and characterizing the effects of small molecules on the activities of UGT1A1 requires reliable tools for …
  • Glycated albumin precipitation using aptamer conjugated magnetic nanoparticles. [Journal Article]
    Sci Rep. 2020 Jul 01; 10(1):10716.Fayazi R, Habibi-Rezaei M, … Taheri RA
  • To develop a strategy for the elimination of prefibrillar amyloid aggregates, a three-step non-modified DNA aptamer conjugation on silica-coated magnetic nanoparticles was carried out to achieve aptamer conjugated on MNP (Ap-SiMNP). Prefibrillar amyloid aggregates are generated under a diabetic condition which are prominently participated in developing diabetic complications. The binding properti…
  • Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue. [Journal Article]
    J Biol Chem. 2020 Jul 01 [Online ahead of print]Zoabi M, Zhang L, … Gozani O
  • Protein lysine methylation is a common posttranslational modification (PTM) throughout the human proteome that plays important roles in diverse biological processes. In humans, there are >100 known and candidate protein lysine methyltransferases (PKMTs), many of which are linked to human diseases. Methyltransferase-like protein 21C (METTL21C) is a PKMT implicated in muscle biology that has been r…
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