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34 results
  • Phenotypic Changes Exhibited by E. coli Cultured in Space. [Journal Article]
    Front Microbiol 2017; 8:1598Zea L, Larsen M, … Klaus D
  • Bacteria will accompany humans in our exploration of space, making it of importance to study their adaptation to the microgravity environment. To investigate potential phenotypic changes for bacteria grown in space, Escherichia coli was cultured onboard the International Space Station with matched controls on Earth. Samples were challenged with different concentrations of gentamicin sulfate to st…
  • Novel finding of optic nerve central T2 hypointensity utilizing 3 Tesla MR imaging. [Journal Article]
    Neuroradiol J 2015; 28(2):133-6Riascos R, Heymann JC, … Kramer LA
  • We sought to report a central T2 hypointensity within the optic nerve on 3 T MRI studies obtained as part of the NASA Flight Medicine Visual Impairment Intracranial Pressure Protocol that had not been described previously. Twenty-one astronauts, who had undergone MRI of both orbits with direct coronal T2 sequences between 2010 and 2012, were retrospectively included. Two of the astronauts did not…
  • Space physiology IV: mathematical modeling of the cardiovascular system in space exploration. [Review]
    Eur J Appl Physiol 2013; 113(8):1919-37Keith Sharp M, Batzel JJ, Montani JP
  • Mathematical modeling represents an important tool for analyzing cardiovascular function during spaceflight. This review describes how modeling of the cardiovascular system can contribute to space life science research and illustrates this process via modeling efforts to study postflight orthostatic intolerance (POI), a key issue for spaceflight. Examining this application also provides a context…
  • Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading. [Journal Article]
    J Bone Miner Res 2013; 28(4):865-74Spatz JM, Ellman R, … Bouxsein ML
  • Sclerostin, a product of the SOST gene produced mainly by osteocytes, is a potent negative regulator of bone formation that appears to be responsive to mechanical loading, with SOST expression increasing following mechanical unloading. We tested the ability of a murine sclerostin antibody (SclAbII) to prevent bone loss in adult mice subjected to hindlimb unloading (HLU) via tail suspension for 21…
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