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3,296 results
  • Homogeneous DNA-only keypad locks enable one-pot assay of multi-inputs. [Journal Article]
    Chem Commun (Camb). 2020 Jun 03 [Online ahead of print]Wei B, Sun X, … Liang H
  • Homogeneous DNA-only keypad locks were built with multi-stranded scalable junction substrates and a series of double-stranded eliminators to differentially process correctly- and wrongly-added DNA inputs, respectively. Unlike conventional strategies that employed solid-phase platforms, one-pot assay of multiple DNA inputs was achieved, showing merits in fabricating complicated information securit…
  • Bioinspired Adhesive and Antibacterial Microneedles for Versatile Transdermal Drug Delivery. [Journal Article]
    Research (Wash D C). 2020; 2020:3672120.Zhang X, Chen G, … Zhao Y
  • Microneedles have attracted increasing interest among various medical fields due to their painless, noninvasive, and efficient way of drug delivery. However, practical applications of these microneedles in different epidermal locations and environments are still restricted by their low adhesion and poor antimicrobial activity. Here, inspired by the antibacterial strategy of Paenibacillus polymyxa…
  • Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration. [Journal Article]
    Int J Mol Sci. 2020 May 30; 21(11)Sharma A, Liu H, … Herwig-Carl MC
  • Emerging evidence suggests an inverse association between cancer and neurodegenerative diseases (NDD). Although phenotypically different, both diseases display a significant imbalance in the ubiquitination/deubiquitination processes. Therefore, we particularly investigated the expression of ubiquitin C-terminal hydrolases (UCHs: UCH-L1, UCH-L3, UCH-L5 and BAP1), a subfamily of deubiquitinating en…
  • Electrical energy harvesting from ferritin biscrolled carbon nanotube yarn. [Journal Article]
    Biosens Bioelectron. 2020 May 22; 164:112318.Kim H, Park JW, … Kim SJ
  • Various studies about harvesting energy for future energy production have been conducted. In particular, replacing batteries in implantable medical devices with electrical harvesting is a great challenge. Here, we have improved the electrical harvesting performance of twisted carbon nanotube yarn, which was previously reported to be an electrical energy harvester, by biscrolling positively charge…
  • Assembly of Foldable 3D Microstructures Using Graphene Hinges. [Journal Article]
    Adv Mater. 2020 May 27 [Online ahead of print]Lim S, Luan H, … Ahn JH
  • Origami/kirigami-inspired 3D assembly approaches have recently attracted attention for a variety of applications, such as advanced optoelectronic devices and biomedical sensors. The results reported here describe an approach to construct classes of multiple foldable 3D microstructures that involve deformations that typical conductive materials, such as conventional metal films, cannot tolerate. A…
  • Oriented boronate affinity-imprinted inverse opal hydrogel for glycoprotein assay via colorimetry. [Journal Article]
    Mikrochim Acta. 2020 May 27; 187(6):348.Wang H, Wang J, … Kong T
  • A biomimetic antibody is described for colorimetric determination of glycoprotein, and horseradish peroxidase (HRP) is used as model analyte. Use is made of oriented surface imprinted inverse opal hydrogel particles functionalized with phenylboronic acid. The inverse opal hydrogel particles were negatively replicated from silica colloidal crystal beads (SCCBs), so that they were endowed with larg…
  • Personalized analysis of breast cancer using sample-specific networks. [Journal Article]
    PeerJ. 2020; 8:e9161.Zhu K, Pian C, … Chen Y
  • Breast cancer is a disease with high heterogeneity. Cancer is not usually caused by a single gene, but by multiple genes and their interactions with others and surroundings. Estimating breast cancer-specific gene-gene interaction networks is critical to elucidate the mechanisms of breast cancer from a biological network perspective. In this study, sample-specific gene-gene interaction networks of…
  • Materials for flexible bioelectronic systems as chronic neural interfaces. [Review]
    Nat Mater. 2020 Jun; 19(6):590-603.Song E, Li J, … Rogers JA
  • Engineered systems that can serve as chronically stable, high-performance electronic recording and stimulation interfaces to the brain and other parts of the nervous system, with cellular-level resolution across macroscopic areas, are of broad interest to the neuroscience and biomedical communities. Challenges remain in the development of biocompatible materials and the design of flexible implant…
  • Emerging Implantable Energy Harvesters and Self-Powered Implantable Medical Electronics. [Journal Article]
    ACS Nano. 2020 Jun 01 [Online ahead of print]Jiang D, Shi B, … Li Z
  • Implantable energy harvesters (IEHs) are the crucial component for self-powered devices. By harvesting energy from organisms such as heartbeat, respiration, and chemical energy from the redox reaction of glucose, IEHs are utilized as the power source of implantable medical electronics. In this review, we summarize the IEHs and self-powered implantable medical electronics (SIMEs). The typical IEHs…
  • Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition. [Journal Article]
    Biosci Rep. 2020 May 26 [Online ahead of print]Yi R, Wang H, … Zhaba W
  • It has been demonstrated from previous studies about the killing effect of dihydroartemisinin(DHA) on glioblastoma, which involves multiple aspects: cytotoxicity, cell cycle arrest and invasion inhibition. DHA has the advantages of low cytotoxicity to normal cells, selective killing effect and low drug resistance, making it one of the popular anti-tumor research directions. Ferroptosis is a newly…
  • An Ordered and Fail-Safe Electrical Network in Cable Bacteria. [Journal Article]
    Adv Biosyst. 2020 May 25 [Online ahead of print]Thiruvallur Eachambadi R, Bonné R, … Manca JV
  • Cable bacteria are an emerging class of electroactive organisms that sustain unprecedented long-range electron transport across centimeter-scale distances. The local pathways of the electrical currents in these filamentous microorganisms remain unresolved. Here, the electrical circuitry in a single cable bacterium is visualized with nanoscopic resolution using conductive atomic force microscopy. …
  • Sensitive Aflatoxin B1 Detection Using Nanoparticle-Based Competitive Magnetic Immunodetection. [Journal Article]
    Toxins (Basel). 2020 May 20; 12(5)Pietschmann J, Spiegel H, … Schröper F
  • Food and crop contaminations with mycotoxins are a severe health risk for consumers and cause high economic losses worldwide. Currently, different chromatographic- and immuno-based methods are used to detect mycotoxins within different sample matrices. There is a need for novel, highly sensitive detection technologies that avoid time-consuming procedures and expensive laboratory equipment but sti…
  • Ubiquitous Electron Transport in Non-Electron Transfer Proteins. [Review]
    Life (Basel). 2020 May 20; 10(5)Lindsay S
  • Many proteins that have no known role in electron transfer processes are excellent electronic conductors. This surprising characteristic is not generally evident in bulk aggregates or crystals, or in isolated, solvated peptides, because the outer hydrophilic shell of the protein presents a barrier to charge injection. Ligands that penetrate this barrier make excellent electrical contacts, yieldin…
  • Electrochemical ELISA Protein Biosensing in Undiluted Serum Using a Polypyrrole-Based Platform. [Letter]
    Sensors (Basel). 2020 May 18; 20(10)Arya SK, Estrela P
  • An electrochemical enzyme-linked immunosorbent assay (ELISA) biosensor platform using electrochemically prepared ~11 nm thick carboxylic functionalized popypyrrole film has been developed for bio-analyte measurement in undiluted serum. Carboxyl polypyrrole (PPy-COOH) film using 3-carboxy-pyrrol monomer onto comb-shaped gold electrode microarray (Au) was prepared via cyclic voltammetry (CV). The p…
  • Finding the equilibrium of organic electrochemical transistors. [Journal Article]
    Nat Commun. 2020 May 20; 11(1):2515.Kaphle V, Paudel PR, … Lüssem B
  • Organic Electrochemical Transistors are versatile sensors that became essential for the field of organic bioelectronics. However, despite their importance, an incomplete understanding of their working mechanism is currently precluding a targeted design of Organic Electrochemical Transistors and it is still challenging to formulate precise design rules guiding materials development in this field. …
  • Bioelectrical understanding and engineering of cell biology. [Journal Article]
    J R Soc Interface. 2020 May; 17(166):20200013.Schofield Z, Meloni GN, … Soyer OS
  • The last five decades of molecular and systems biology research have provided unprecedented insights into the molecular and genetic basis of many cellular processes. Despite these insights, however, it is arguable that there is still only limited predictive understanding of cell behaviours. In particular, the basis of heterogeneity in single-cell behaviour and the initiation of many different met…
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