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9,336 results
  • Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin. [Journal Article]
    Elife 2019; 8Stowe CL, Burley TA, … Pule MA
  • Bioluminescence imaging (BLI) is ubiquitous in scientific research for the sensitive tracking of biological processes in small animal models. However, due to the attenuation of visible light by tissue, and the limited set of near-infrared bioluminescent enzymes, BLI is largely restricted to monitoring single processes in vivo. Here we show, that by combining stabilised colour mutants of firefly l…
  • Current Approaches of Drug Discovery for Chagas Disease: Methodological Advances. [Journal Article]
    Comb Chem High Throughput Screen 2019Scarim CB, Chin CM
  • In recent years, there has been an improvement in the in vitro and in vivo methodology for the screening of anti-chagasic compounds. Millions of compounds can now have their activity evaluated (in large compound libraries) by means of high throughput in vitro screening assays. <p> Objective: Current approaches of drug discovery for Chagas disease. <p> Method: This review article examines the cont…
  • Insights Into Nitric Oxide Modulated Quorum Sensing Pathways. [Review]
    Front Microbiol 2019; 10:2174Heckler I, Boon EM
  • The emerging threat of drug resistant bacteria has prompted the investigation into bacterial signaling pathways responsible for pathogenesis. One such mechanism by which bacteria regulate their physiology during infection of a host is through a process known as quorum sensing (QS). Bacteria use QS to regulate community-wide gene expression in response to changes in population density. In order to…
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