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297 results
  • Discovery and replication of cerebral blood flow differences in major depressive disorder. [Journal Article]
    Mol Psychiatry 2019Cooper CM, Chin Fatt CR, … Trivedi MH
  • Major depressive disorder (MDD) is a serious, heterogeneous disorder accompanied by brain-related changes, many of which are still to be discovered or refined. Arterial spin labeling (ASL) is a neuroimaging technique used to measure cerebral blood flow (CBF; perfusion) to understand brain function and detect differences among groups. CBF differences have been detected in MDD, and may reveal biosi…
  • HSPB1 rs2070804 polymorphism is associated with the depth of primary tumor. [Journal Article]
    J Cell Biochem 2019Hung CS, Huang CY, … Wei PL
  • CONCLUSIONS: The polymorphisms of HSPB1 seemed to change the tumor behavior of colorectal cancer. HSPB1 rs2070804 polymorphism is associated with the depth of the primary tumor. But, there is no further correlation with other to the clinical parameters such as cancer invasiveness, local recurrence, or distant metastasis.
  • Metabolic Disturbances Identified in Plasma Samples from ST-Segment Elevation Myocardial Infarction Patients. [Journal Article]
    Dis Markers 2019; 2019:7676189Goulart VAM, Santos AK, … Resende RR
  • ST-segment elevation myocardial infarction (STEMI) is the most severe form of myocardial infarction (MI) and the main contributor to morbidity and mortality caused by MI worldwide. Frequently, STEMI is caused by complete and persistent occlusion of a coronary artery by a blood clot, which promotes heart damage. STEMI impairment triggers changes in gene transcription, protein expression, and metab…
  • Salivary metabolomics of total body irradiated non-human primates reveals long term normal tissue responses to radiation. [Journal Article]
    Int J Radiat Oncol Biol Phys 2019Laiakis EC, Nishita D, … Fornace AJ
  • CONCLUSIONS: Untargeted metabolomic analysis revealed significant and persistent effects up to the 60 days evaluated in this study. Biomarkers spanning primarily amino acids and nucleotides were identified with a significant number of them showing long term responses. Fifteen biomarkers showed high statistical significance in the first week after irradiation, and sixteen at >7 days after irradiation [false discovery rate (FDR) adjusted p<0.05]. The combination of the biomarkers in a single biosignature was able to accurately show the diagnostic ability of the signature in a binary classifier system with ROC curves. Radiation therefore can alter the metabolome in saliva and metabolomics could effectively be used to monitor radiation responses, as a biodosimetry method, in the event of a radiological incident; saliva metabolomics also has potential relevance in a clinical setting.
  • Deciphering Biosignatures in Planetary Contexts. [Journal Article]
    Astrobiology 2019Chan MA, Hinman NW, … Cleaves HJ
  • Microbial life permeates Earth's critical zone and has likely inhabited nearly all our planet's surface and near subsurface since before the beginning of the sedimentary rock record. Given the vast time that Earth has been teeming with life, do astrobiologists truly understand what geological features untouched by biological processes would look like? In the search for extraterrestrial life in th…
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