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(black cohosh)
852 results
  • Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract. [Journal Article]
    Environ Mol Mutagen 2019Bernacki DT, Bryce SM, … Smith-Roe SL
  • Black cohosh extract (BCE) is a popular botanical dietary supplement marketed to relieve symptoms of various gynecological ailments. Studies conducted by the National Toxicology Program (NTP) showed that BCE induces micronucleated erythrocytes in female rats and mice. Subsequently, the NTP showed that a variety of BCEs, including the sample that induced micronuclei (MN) in vivo ("NTP BCE") had a …
  • Profiles of Phenolic Acids and Triterpene Glycosides in Commercial and Cultivated Black Cohosh. [Journal Article]
    Planta Med 2019Bittner M, Schenk R, … Melzig MF
  • The medicinal plant Actaea racemosa is a perennial, whose rhizome (black cohosh rhizome) is usually wild harvested on a multiton scale to meet market requirements. Since this North American species is increasingly endangered, cultivation is needed. Even though studies prove that cultivation is possible, it has not been widely established. This may be due to a different quality of cultivated mater…
  • One new and seven known triterpene glycosides from the aerial parts of Cimicifuga dahurica. [Journal Article]
    J Asian Nat Prod Res 2019; :1-6Hao YM, Luo W, … Lu JC
  • One new triterpene glycoside, asiaticoside I (1), along with seven known ones (2-8), were isolated from the aerial parts of Cimicifuga dahurica (Turcz.) Maxim. The structure of 1 was elucidated on the basis of extensive spectroscopic methods including 1D-NMR, 2D-NMR and MS data. The structures of known compounds were determined by comparison with the literature data. Compound 1 exhibited moderate…
  • Cytotoxic 9,19-cycloartane Triterpenoids from the Roots of Actaea dahurica. [Journal Article]
    Fitoterapia 2019; 137:104262Wang XY, Li CJ, … Zhang DM
  • Eight undescribed 9,19-cycloartane type triterpenoid glycosides (cimdalglnoside A-H) and ten known analogues were obtained from the phytochemical research on the roots of Actaea dahurica (syn. Cimicifuga dahurica). All compounds were characterised by spectroscopic experiments, and chemical method. All the compounds isolated were assayed for cytotoxicity to five human cancer cell lines. Cimdalglno…
  • Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida. [Journal Article]
    Nat Prod Bioprospect 2019; 9(4):303-310Lu J, Peng XR, … Qiu MH
  • To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1-8) were isolated from the mother liquid. The chemical structures of new compounds (1-4) were elucidated by 1D and 2D…
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