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44,350 results
  • Multilayered rule-based expert system for diagnosing uveitis. [Journal Article]
    Artif Intell Med 2019; 99:101691Mutawa AM, Alzuwawi MA
  • Uveitis is a condition caused by inflammation of the uvea, which is the middle layer of the eye. Uveitis can result in swelling or destruction of the eye tissue, which can lead to visual impairment or blindness [1]. Many diseases, either systemic or localized to the eye, are associated with the symptoms of uveitis. Thus, it is often hard to determine the underlying disease responsible for uveitis…
  • Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy. [Journal Article]
    Mol Ther 2019Gardiner KL, Cideciyan AV, … Aguirre GD
  • The form of hereditary childhood blindness Leber congenital amaurosis (LCA) caused by biallelic RPE65 mutations is considered treatable with a gene therapy product approved in the US and Europe. The resulting vision improvement is well accepted, but long-term outcomes on the natural history of retinal degeneration are controversial. We treated four RPE65-mutant dogs in mid-life (age = 5-6 years) …
  • Blindness, Psychosis, and the Visual Construction of the World. [Journal Article]
    Schizophr Bull 2019Pollak TA, Corlett PR
  • The relationship between visual loss and psychosis is complex: congenital visual loss appears to be protective against the development of a psychotic disorder, particularly schizophrenia. In later life, however, visual deprivation or visual loss can give rise to hallucinosis, disorders of visual insight such as blindsight or Anton syndrome, or, in the context of neurodegenerative disorders, more …
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