- Friction Blister by Climbing Harness: A Case Report. [Journal Article]
- WEWilderness Environ Med 2019 Jun 20
- An experienced 24-y-old climber on Mount Everest presented to the Base Camp medical clinic with a friction blister on his right flank. The blister was filled with clear fluid and was located about 3 …
An experienced 24-y-old climber on Mount Everest presented to the Base Camp medical clinic with a friction blister on his right flank. The blister was filled with clear fluid and was located about 3 cm posterior and 3 cm superior to the highest point of the right iliac crest, the site where a climbing harness would support the climber while hanging. A diagnosis of friction blister caused by a climbing harness used while traversing between Camp 2 and Camp 3 of Mount Everest was made. The blister was managed with hydrocolloid dressing, and the patient resumed climbing after 1 wk. The lesion healed with scarring at 2 wk. Friction blisters of the feet are common in climbers wearing ill-fitting shoes, but friction blisters caused by climbing harnesses are unusual and have not been reported in the literature as far as the authors are aware. All existing guidelines for blister management pertain to blisters of the feet, and there are inconsistencies in recommendations made by various authors. This unusual case in an extreme environment provides a good learning opportunity.
- Cultured Epidermal Melanocyte Transplantation in Vitiligo: A Review Article. [Review]
- IJIran J Public Health 2019; 48(3):388-399
- CONCLUSIONS: In this review, autologous cultured melanocyte transplantation has been considered to be the most viable, safe, and effective method in the history of vitiligo treatments.
- Buckling morphology of an elastic ring confined in an annular channel. [Journal Article]
- SMSoft Matter 2019 Jun 20
- This paper studies the buckling morphology transition of an elastic ring confined in an annular channel. Under uniform axial strain, the ring would first form one inward blister and then transit to a…
This paper studies the buckling morphology transition of an elastic ring confined in an annular channel. Under uniform axial strain, the ring would first form one inward blister and then transit to an "S" shape, but does not induce more blisters due to an energy barrier caused by the annular shape of the channel. In order to overcome the energy barrier, external perturbation is employed and a stable morphology with multiple blisters may be obtained. A theoretical framework is then established to calculate the bifurcation points of the shape transition, which agrees well with finite-element (FEM) simulation results. The diagrams of the stable buckling morphologies with respect to the geometrics of the elastic rings are presented, which may provide useful insights for practical applications, for example, the design of a peristaltic pump.
- Blue Blister on Forearm. [Journal Article]
- DADtsch Arztebl Int 2019 May 03; 116(18):316
- A new ex vivo human oral mucosa model reveals that p38MAPK inhibition is not effective to prevent autoantibody-induced mucosal blistering in pemphigus. [Journal Article]
- BJBr J Dermatol 2019 Jun 19
- CONCLUSIONS: In contrast to human epidermis, PV-IgG and AK23 induced blisters and desmosome ultrastructural changes in labial mucosa via a mechanism not dependent on p38MAPK. This article is protected by copyright. All rights reserved.
- Clipping on Crossed Wrapping Method for Ruptured Blood Blister-Like Aneurysm of the Internal Carotid Artery: Technical Note and Long-Term Results. [Journal Article]
- WNWorld Neurosurg X 2019; 2:100005
- CONCLUSIONS: It is suggested that COCW is a treatment that enables safe and long-term management of lesions in IC-BLAs.
- Tamoxifen affects the histology and hepatopancreatic lipid metabolism of swimming crab Portunus trituberculatus. [Journal Article]
- ATAquat Toxicol 2019 Jun 03; 213:105220
- Tamoxifen (TAM) is an antiestrogenic agent and can enter the aquatic environment in wastewater. It has been reported that TAM can induce hepatic steatosis in vertebrates, however, the effects of TAM …
Tamoxifen (TAM) is an antiestrogenic agent and can enter the aquatic environment in wastewater. It has been reported that TAM can induce hepatic steatosis in vertebrates, however, the effects of TAM exposure on lipid metabolism of hepatopancreas in crustaceans remains unclear. In this study, four TAM concentrations (0, 6.7, 13.4 and 20 μg g-1 crab body weight) were injected into the swimming-leg of swimming crabs Portunus trituberculatus, as a means of evaluating the effects of TAM on the expression levels of lipid metabolism-related genes, lipid composition, and hepatopancreas histology. The results showed that the mRNA levels of three lipogenic related genes (diacylglycerol acyltransferase 1 (DGAT1), acetyl-CoA carboxylase (ACC) and fatty acyl desaturase (FAD)) decreased significantly in the 6.7 μg g-1 and 20 μg g-1 TAM treatments compare to the control. The mRNA levels of fatty acid synthase (FAS) decreased significantly in a dose-dependent manner as TAM concentration increased. The mRNA levels of two lipid catabolism-related genes (acyl-CoA oxidase (ACOX) and fatty acid transport protein (FATP)) were down-regulated among the three TAM treatments, while the enzyme activity and mRNA level of carnitine palmitoyltransferase I (CPT-I) was up-regulated by TAM treatments. Compared to the control, the lowest levels of total lipids and phospholipids were detected in the 6.7 μg g-1 TAM treatment, while the 20 μg g-1 TAM treatment had the lowest free fatty acids concentration. The 6.7 μg g-1 TAM treatment had the lowest percentages of 16:1n-7, 18:1n-9, 18:1n-7 and total monounsaturated fatty acids (∑MUFA), whilst simultaneously recording the highest percentages of 18:2n-6 and 20:2n-6 in this treatment. Moreover, histological observations indicated that TAM caused the walls of the hepatopancreatic tubules to become brittle, with a concurrent increase in the number of blister-like cells. These results suggest that TAM damages the hepatopancreas and leads to a reduction in hepatopancreatic lipid deposition in P. trituberculatus.
- Cerebral arterial gas embolism in a scuba diver with a primary lung bulla. [Case Reports]
- DHDiving Hyperb Med 2019 Jun 30; 49(2):141-144
- Primary lung bullae have been reported to cause pulmonary barotrauma and lead to cerebral arterial gas embolism (CAGE) in the context of diving; however, a lack of symptoms and often minimal radiogra…
Primary lung bullae have been reported to cause pulmonary barotrauma and lead to cerebral arterial gas embolism (CAGE) in the context of diving; however, a lack of symptoms and often minimal radiographic findings often preclude a diagnosis of lung bullae prior to undertaking diving activity. We present the case of a healthy 27-year-old Caucasian male who presented following the second of two introductory resort dives with neurological symptoms attributable to CAGE. Investigations revealed a previously undiagnosed large primary lung bulla. This case highlights the clinical sequelae of primary lung bullae in the context of pulmonary barotrauma related to recreational diving activity.
- Bullous Lupus Under Nivolumab Treatment for Lung Cancer: A Case Report With Systematic Literature Review. [Case Reports]
- ARAnticancer Res 2019; 39(6):3003-3008
- CONCLUSIONS: To our knowledge, this is the first description of a bullous lupus exacerbated by nivolumab.
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- Occupational therapy for epidermolysis bullosa: clinical practice guidelines. [Review]
- OJOrphanet J Rare Dis 2019 Jun 07; 14(1):129
- The purpose of this article is to summarize the Dystrophic Epidermolysis Bullosa Research Association (DEBRA) International evidence-based Clinical Practice Guidelines (CPGs) for the provision of occ…
The purpose of this article is to summarize the Dystrophic Epidermolysis Bullosa Research Association (DEBRA) International evidence-based Clinical Practice Guidelines (CPGs) for the provision of occupational therapy (OT) for children and adults living with inherited epidermolysis bullosa (EB). This is a rare genetic disorder characterized by skin fragility leading to blister formation occurring spontaneously or following minor trauma. Current OT practice for persons with EB is based on anecdotal care, clinical expertise and trial and error with collaboration between caregiver and patient. Intervention based on research is needed to establish a foundation of knowledge to guide international practitioners to create and improve standards of care and to be able to work effectively with those living with the rare diagnosis of this condition.This CPG was created by an international panel with expertise working with persons with EB. The panel was made up of 11 members including OT's, a physiotherapist, a medical doctor, social worker, person with EB and a carer of a person with EB. It describes the development of recommendations for 5 outcomes determined by survey of persons with EB, caregivers, and experienced healthcare professionals. The outcomes include independence in activities of daily living (ADL), independence in instrumental ADL, maximization of hand function (non-surgical), fine motor development and retention, and oral feeding skills. The recommendations are supplemented with additional files that include photos and specific examples to further guide occupational therapists or, in situations where an OT is not available, other members of the healthcare team.As the disorder of EB is rare, evidence-based CPGs are needed to provide a base of knowledge and practice for OTs throughout the world with the goal of providing quality care to patients, while improving their functional independence and quality of life. In addition, this information is valuable as a basis for further research.