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305,289 results
  • Ratiometric GPCR signaling enables directional sensing in yeast. [Journal Article]
    PLoS Biol 2019; 17(10):e3000484Henderson NT, Pablo M, … Lew DJ
  • Accurate detection of extracellular chemical gradients is essential for many cellular behaviors. Gradient sensing is challenging for small cells, which can experience little difference in ligand concentrations on the up-gradient and down-gradient sides of the cell. Nevertheless, the tiny cells of the yeast Saccharomyces cerevisiae reliably decode gradients of extracellular pheromones to find thei…
  • Reliability of Protein Abundance and Synthesis Measurements in Human Skeletal Muscle. [Journal Article]
    Proteomics 2019; :e1900194Srisawat K, Hesketh K, … Burniston JG
  • We investigated the repeatability of dynamic proteome profiling (DPP), which is a novel technique for measuring the relative abundance (ABD) and fractional synthesis rate (FSR) of proteins in humans. LC-MS analysis was performed on muscle samples taken from male participants (n = 4) that consumed 4 × 50 ml doses of deuterium oxide (2 H2 O) per day for 14 d. ABD was measured by label-free quantita…
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