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Unbound Medicine.
(breath actuation)
74 results
  • Asthma management with breath-triggered inhalers: innovation through design. [Review]
    Asthma Res Pract. 2020; 6:4.Morais-Almeida M, Pité H, … Marques JA
  • CONCLUSIONS: BTI R&D can bring advantage over current available inhalers, avoiding the two most common identified critical errors in inhalation technique. K-haler® BTI is currently available, without an increased cost, and approved for adolescents and adults with asthma in whom treatment with inhaled combined therapy with long-acting beta2-agonists and corticosteroids is indicated. Its attractive and practical design to facilitate its use has been awarded. K-haler® represents added value through innovation to fulfill actual asthma patient needs, thus with potential relevant impact in asthma management and effective control.
  • Wet-Side Breath-Enhanced Jet Nebulization: Controlling Drug Delivery During Mechanical Ventilation. [Journal Article]
    Respir Care. 2020 Mar 24 [Online ahead of print]Cuccia AD, Ashraf S, … Smaldone GC
  • CONCLUSIONS: Breath enhancement with breath actuation provided a predictable dose at any ventilator setting or type of humidification. Preservation of drug delivery during active humidification is a new finding, compared with previous studies. The use of wall gases and stand alone breath actuation standardizes conditions that drive the nebulizer independent of ventilator design. Wet-side nebulizer placement at the humidifier outlet allows delivery without introducing aerosol into the humidification chamber.
  • Recent advances in aerosol devices for the delivery of inhaled medications. [Journal Article]
    Expert Opin Drug Deliv. 2020 Feb; 17(2):133-144.Ari A, Fink JB
  • Introduction: Aerosolized medications are commonly prescribed for the treatment of patients with pulmonary diseases, and there has been an increased interest in the development of aerosol delivery devices over the years. Technical innovations have advanced device design, novel features such as breath actuation, dose tracking, portability, and feedback mechanism during treatment that improved the …
  • Development of a novel digital breath-activated inhaler: Initial particle size characterization and clinical testing. [Clinical Trial]
    Pulm Pharmacol Ther. 2018 12; 53:27-32.Kesten S, Israel E, … Stern T
  • CONCLUSIONS: The DBAI generated highly respirable aerosols containing albuterol sulfate that were similar to the MDI and SMI in respirable fraction but lower in dose. Subsequent pharmacodynamic studies delivering albuterol sulfate alone and in combination with ipratropium bromide confirmed similar responses for the DBAI compared with the other inhalers, which could possibly be related to a response ceiling. The DBAI breath-activated capability combined with the ability to monitor actual delivery of medication may improve effectiveness by overcoming patient miscoordination.
  • Investigation of multiphase multicomponent aerosol flow dictating pMDI-spacer interactions. [Journal Article]
    Int J Pharm. 2017 Aug 30; 529(1-2):264-274.Sarkar S, Peri SP, Chaudhuri B
  • The use of Pressurized metered dose inhalers (pMDIs) for the treatment of asthma and other chronic obstructive pulmonary diseases is frequently associated with breath-actuation synchronization problems and poor pulmonary delivery, particularly amongst the pediatric and geriatric population groups. Spacers, or Valved Holding Chambers (VHCs), are frequently used to address these problems. However, …
  • Pharmacokinetics, pharmacodynamics, and clinical efficacy of albuterol RespiClick(™) dry-powder inhaler in the treatment of asthma. [Review]
    Expert Opin Drug Metab Toxicol. 2016 Sep; 12(9):1109-19.Welch MJ
  • CONCLUSIONS: The albuterol mDPI has an efficacy/tolerability profile consistent with other inhaled forms of albuterol, and is reliable, easy to use, and associated with a high level of patient satisfaction. This is the first albuterol dry-powder inhaler (DPI) to become available in the USA, with most other formulations being delivered using a pressurized metered-dose inhaler (pMDI). The availability of a breath-actuated device avoids the challenge of coordinating actuation and breathing when using pMDIs, and could simplify treatment for patients also using a DPI for controller medication. Additional features of RespiClick, such as an integrated dose counter and minimal pre-inhalation preparation, facilitate its use.
  • Pulmonary monoclonal antibody delivery via a portable microfluidic nebulization platform. [Journal Article]
    Biomicrofluidics. 2015 Sep; 9(5):052603.Cortez-Jugo C, Qi A, … Yeo LY
  • Nebulizers have considerable advantages over conventional inhalers for pulmonary drug administration, particularly because they do not require coordinated breath actuation to generate and deliver the aerosols. Nevertheless, besides being less amenable to miniaturization and hence portability, some nebulizers are prone to denature macromolecular drugs due to the large forces generated during aeros…
  • [Influence of inhaler and fine particle on efficacy of inhalation therapy in COPD]. [Review]
    Pneumonol Alergol Pol. 2014; 82(3):300-10.Sliwiński P, Chazan R, … Pirożyński M
  • Orally inhaled products delivered via inhalation exert their effect directly to the target organ. This allows to administer a very low dose of a drug compared with an oral route with similar clinical effect and significantly reduced toxicity. However inhalation therapy is also limited by several factors. Delivery of the desired dose of the drug to the airways depends on a type of the inhaler - pr…
  • Overcoming dose limitations using the orbital(®) multi-breath dry powder inhaler. [Journal Article]
    J Aerosol Med Pulm Drug Deliv. 2014 Apr; 27(2):138-47.Young PM, Crapper J, … Traini D
  • CONCLUSIONS: The systems were different in terms of morphology, thermal response, moisture sorption, and stability; however, they had similar sizes when measured by laser diffraction, making them suitable for comparison in the Orbital and RS01 devices. The aerosolization performance from the Orbital device and RS01 was dependent on the formulation type; however, the fine particle fraction (FPF) produced by the Orbital device was higher than that by the RS01. The FPFs for ciprofloxacin, mannitol, and co-spray-dried formulation were 67.1±1.8, 47.1±2.2, and 42.0±1.8, respectively. For the Orbital, 90% of the loaded dose was delivered within 10 inhalation maneuvers, with the profile being dependent on the formulation type.The Orbital provides a means of delivering high doses of medicine to the respiratory tract through multiple breath maneuvers after a single actuation. This approach will allow the delivery of a wide range of high-payload formulations (>100 mg) for the treatment of a variety of lung disorders. To date, no such passive device exists that meets these crucial criteria.
  • A new methodology for intra-breath control of mechanical ventilation. [Journal Article]
    Med Eng Phys. 2012 Mar; 34(2):256-60.Cecchini S, Sardellitti I, Silvestri S
  • Recent improvements in digital control strategies are driving the implementation of innovative pulmonary ventilation modalities able to support the physician in the intensive care through a better management of the patient's respiratory pathologies. New control strategies, such as intra-breath ones, which guarantee successful patient-machine synchronization and dynamic adjustment to the patient, …
  • Aerosol drug delivery: developments in device design and clinical use. [Review]
    Lancet. 2011 Mar 19; 377(9770):1032-45.Dolovich MB, Dhand R
  • Aerosolised drugs are prescribed for use in a range of inhaler devices and systems. Delivering drugs by inhalation requires a formulation that can be successfully aerosolised and a delivery system that produces a useful aerosol of the drug; the particles or droplets need to be of sufficient size and mass to be carried to the distal lung or deposited on proximal airways to give rise to a therapeut…
  • Ultrasonic nebulization platforms for pulmonary drug delivery. [Review]
    Expert Opin Drug Deliv. 2010 Jun; 7(6):663-79.Yeo LY, Friend JR, … Morton DA
  • CONCLUSIONS: Recent advances in ultrasonic nebulization technology demonstrate significant potential for the development of smart, portable inhalation therapy platforms for the future. Nevertheless, there remain considerable challenges that need to be addressed before such personalized delivery systems can be realized. These have to be addressed across the spectrum from fundamental physics through to in vivo device testing and dealing with the relevant regulatory framework.
  • Inhaled corticosteroid therapy with nebulized beclometasone dipropionate. [Review]
    Pulm Pharmacol Ther. 2010 Jun; 23(3):145-55.Nicolini G, Cremonesi G, Melani AS
  • Inhaled corticosteroids (ICS) are the most effective anti-inflammatory agents for the management of chronic persistent asthma and are therefore recommended as first-line antiasthmatic therapy in children and adults. In various settings, the administration of ICS via nebulizer rather than hand-held inhaler (HHI) may have certain advantages, as many patients with HHI fail to use these devices prope…
  • Optimized aerosol delivery to a mechanically ventilated rodent. [Journal Article]
    J Aerosol Med Pulm Drug Deliv. 2009 Dec; 22(4):323-32.MacLoughlin RJ, Higgins BD, … O'Brien T
  • CONCLUSIONS: This optimized experimental setup allows for greater inhaled mass than previously reported. The addition of a recycling step may prove to be a significant improvement in achieving higher deposition in mechanically ventilated lungs; however, the suitability of the test agent for repeated nebulization needs assessment.
  • Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. [Review]
    Respir Med. 2008 Apr; 102(4):593-604.Lavorini F, Magnan A, … Crompton GK
  • CONCLUSIONS: This review demonstrates that incorrect DPI technique with established DPIs is common among patients with asthma and COPD, and suggests that poor inhalation technique has detrimental consequences for clinical efficacy. Regular assessment and reinforcement of correct inhalation technique are considered by health professionals and caregivers to be an essential component of successful asthma management. Improvement of asthma and COPD management could be achieved by new DPIs that are easy to use correctly and are forgiving of poor inhalation technique, thus ensuring more successful drug delivery.
  • Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children. [Journal Article]
    Eur Respir J. 2007 Feb; 29(2):299-306.Roller CM, Zhang G, … Devadason SG
  • The aim of the present study was to measure airway, oropharyngeal and gastrointestinal deposition of (99m)Tc-labelled hydrofluoroalkane-beclomethasone dipropionate after inhalation via a pressurised metered-dose inhaler and spacer (Aerochamber Plus) in asthmatic children. A group of 24 children (aged 5-17 yrs) with mild asthma inhaled the labelled drug. A total of 12 children took five tidal brea…
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