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4,816 results
  • The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. [Journal Article]
    J Pharmacol Exp Ther 2019Chen YC, Fowler JP, … Fowler CD
  • During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by CYP2A6. Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies sought to validate a novel CYP2A6 inhibitor, (5-(4-ethylpyridin-3-yl)thiophen-2-yl)methanamine (DLCI-1), for its effects on intravenous nicotine self-administration. Ma…
  • A review of systemic medications that may modulate the risk of glaucoma. [Review]
    Eye (Lond) 2019Wu A, Khawaja AP, … Stein JD
  • With increasing longevity, patients are developing more and more chronic diseases that require treatment with medications. Yet, it is not fully understood the extent by which these systemic medications affect ocular structures and whether they may increase or decrease the risk of sight-threatening ocular diseases. This review provides a summary of reported associations between different systemic …
  • Management Strategies for Antidepressant-Related Sexual Dysfunction: A Clinical Approach. [Review]
    J Clin Med 2019; 8(10)Montejo AL, Prieto N, … Montejo L
  • Major depressive disorder is a serious mental disorder in which treatment with antidepressant medication is often associated with sexual dysfunction (SD). Given its intimate nature, treatment emergent sexual dysfunction (TESD) has a low rate of spontaneous reports by patients, and this side effect therefore remains underestimated in clinical practice and in technical data sheets for antidepressan…
  • Cytochrome P450-Mediated Metabolic Characterization of a Mono-Carbonyl Curcumin Analog WZ35. [Journal Article]
    Pharmacology 2019; :1-11Wang G, Li Y, … Zhang X
  • WZ35 is a monocarbonyl analog of curcumin, which had been proved advantage over curcumin in chemical stability and antitumor activity. However, its pharmacokinetic profile has not been determined. In the present study, an ultraperformance liquid chromatography-tandem mass spectrometry assay was developed to detect concentration of WZ35 in rat plasma. Subsequently, pharmacokinetic study showed tha…
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