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Unbound Medicine.
(butalbital acetaminophen†)
34 results
  • Posterior Reversible Encephalopathy Syndrome Caused by Fioricet (Butalbital-Acetaminophen-Caffeine). [Case Reports]
    Case Rep Med. 2019; 2019:5410872.Cret N, Halalau M, … Halalau A
  • A common side effect of Fioricet (butalbital-acetaminophen-caffeine) is high blood pressure caused by the caffeine content. We report a case of a 54-year-old female who developed the worst headache of her life after taking 2 tablets of butalbital-acetaminophen-caffeine every six hours for three days before presenting to the emergency department, where her blood pressure was 178/87 mmHg. A brain M…
  • Headache in Pregnancy and the Puerperium. [Review]
    Neurol Clin. 2019 02; 37(1):31-51.Burch R
  • Migraine is the most common cause of headache during pregnancy. Pregnancy increases risk for many causes of headache, including pathologic vascular processes. Headache associated with neurologic signs or symptoms or that is progressive and refractory to treatment; acute in onset; and severe, postural, or different from typical headaches should be evaluated. Work-up should include cerebral and cer…
  • Migraine Treatment in Pregnant Women Presenting to Acute Care: A Retrospective Observational Study. [Journal Article]
    Headache. 2019 02; 59(2):173-179.Hamilton KT, Robbins MS
  • CONCLUSIONS: While the majority of pregnant women with acute migraine received medications considered relatively safe in pregnancy, there was variation in treatment choice and sequence. Some acute medications considered potentially hazardous for fetal health and less effective for migraine (opioids and butalbital) were used frequently, whereas other treatments that may have low teratogenic risk (nerve blocks, IV fluid boluses, and triptans) were used less or not at all. These results indicate a need for developing guidelines and protocols to standardize acute treatment of migraine in pregnancy.
  • Medication Overuse Headache Due to Butalbital, Acetaminophen, and Caffeine Tablets. [Journal Article]
    J Pain Palliat Care Pharmacother. 2016 Jun; 30(2):148-9.Feeney R
  • Questions from patients about pain conditions and analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. Medication overuse headache is a relatively common cause for chronic daily headache in the migraine patient. In reply to a question, medication overuse headache is reviewed, acute and preventive medications are d…
  • Managing Migraine During Pregnancy and Lactation. [Review]
    Curr Neurol Neurosci Rep. 2016 Apr; 16(4):40.Wells RE, Turner DP, … Strauss L
  • While over half of women with migraine report improvement during pregnancy, having a history of migraine may increase the chance of negative health outcomes. The state of pregnancy increases the risk of several dangerous secondary headache disorders, especially those associated with hypertensive disorders of pregnancy, and providers need to know the red flags to diagnose and treat emergently. Non…
  • Sustained hypotension following intravenous metoclopramide. [Case Reports]
    Ann Pharmacother. 2013 Nov; 47(11):1577-80.Nguyen TT, Petzel Gimbar RM
  • CONCLUSIONS: There are few published case reports of metoclopramide-induced hypotension in the current literature. Of those published, all showed transient hypotension with metoclopramide, lasting seconds to minutes. An objective causality assessment for drug-associated adverse drug reaction showed metoclopramide as a probable cause of the patient's hypotension (Naranjo score of 5). In this case, several indicators of metoclopramide induced hypotension were evident, including the timing of the hypotension after drug administration and the lack of any other possible causes of hypotension. This is the first published case report of sustained hypotension due to intravenous metoclopramide.Intravenous metoclopramide may cause sustained episodes of hypotension.
  • Canadian Headache Society Guideline: acute drug therapy for migraine headache. [Guideline]
    Can J Neurol Sci. 2013 Sep; 40(5 Suppl 3):S1-S80.Worthington I, Pringsheim T, … Canadian Headache Society Acute Migraine Treatment Guideline Development Group
  • CONCLUSIONS: This guideline provides evidence-based advice on acute pharmacological migraine therapy, and should be helpful to both health professionals and patients, The available medications have been organized into a series of strategies based on patient clinical features. These strategies may help practitioners make appropriate acute medication choices for patients with migraine.
  • Clinical aspects of medication overuse headaches. [Review]
    Headache. 2014 Jan; 54(1):211-7.Da Silva AN, Lake AE
  • Medication overuse headache (MOH) is a subset of chronic daily headache, occurring from overuse of 1 or more classes of migraine abortive medication. Acetaminophen, combination analgesics (caffeine combinations), opioids, barbiturates (butalbital), non-steroidal anti-inflammatory drugs, and triptans are the main classes of drugs implicated in the genesis of MOH. Migraine seems to be the most comm…
  • Sumatriptan-naproxen and butalbital: a double-blind, placebo-controlled crossover study. [Randomized Controlled Trial]
    Headache. 2012 Apr; 52(4):530-43.Derosier F, Sheftell F, … Peykamian M
  • CONCLUSIONS: This study primarily included subjects whose migraines significantly impacted their lives. Before the study, these subjects used butalbital-containing medications as part of their current migraine treatment regimen and were satisfied with it, suggesting they were butalbital responders who had found a workable treatment strategy for themselves. When treated with SumaRT/Nap versus BCM in this study, however, a significant proportion of subjects reported better treatment outcomes for themselves for both migraine pain and associated symptoms. Use of SumaRT/Nap was also associated with less rescue medication use and a longer time before use of rescue medication compared with both BCM and placebo.
  • Renal infarction during the use of rizatriptan and zolmitriptan: two case reports. [Case Reports]
    Clin Toxicol (Phila). 2006; 44(2):177-80.Fulton JA, Kahn J, … Hoffman RS
  • Rizatriptan and zolmitriptan are both used to relieve acute migraine and cluster headaches. The mechanism of action is similar to the other triptans, in that they reverse abnormal cerebral vasodilation through their activity as 5-HT1B receptor agonists. Triptan-induced vasoconstriction is attributed to its activity on peripheral 5-HT1B receptors and has rarely been reported to result in stroke, m…
  • Glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephrotic syndrome. [Case Reports]
    Am J Kidney Dis. 2005 Oct; 46(4):e55-8.Sekhon I, Munjal S, … Ejaz AA
  • Glomerular tip lesion and its relation to different glomerular diseases is a subject of controversy. The therapeutic and prognostic clinical implications of glomerular tip lesions are ambiguous. We present a case of glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephrotic syndrome that further complicates this issue. To our knowledge, this is the first case repo…
  • Barbiturate withdrawal following Internet purchase of Fioricet. [Case Reports]
    Arch Neurol. 2004 Jul; 61(7):1111-2.Romero CE, Baron JD, … Ropper AH
  • CONCLUSIONS: The withdrawal state from barbiturates is similar to that from ethanol. Tolerance can develop with prolonged abuse, leading to escalating drug doses to achieve the desired effect. The suggested management of both types of withdrawal syndromes is similar, but the relative resistance of the behavioral and autonomic features in patients was remarkable. Physicians should be aware of the ease with which medications can be purchased without supervision from Internet pharmacies. The magnitude of the number of drugs that are made available through this means creates a proclivity to withdrawal states.
  • Butalbital in the treatment of headache: history, pharmacology, and efficacy. [Review]
    Headache. 2001 Nov-Dec; 41(10):953-67.Silberstein SD, McCrory DC
  • Analgesics containing butalbital compounded with aspirin, acetaminophen, and/or caffeine are widely used for the treatment of migraine and tension-type headache. The butalbital-containing compounds are efficacious in placebo-controlled trials among patients with episodic tension-type headaches. Despite their frequent clinical use for migraine, they have not been studied in placebo-controlled tria…
  • Analgesic rebound headache in clinical practice: data from a physician survey. [Journal Article]
    Headache. 1996 Jan; 36(1):14-9.Rapoport A, Stang P, … Fox AW
  • CONCLUSIONS: Analgesic rebound headache was recognized as a distinct entity and a substantive component in more than 40% of the practices of 174 surveyed practitioners. General practitioners, who see a wide variety of patient types with a spectrum of complaints, need to be able to diagnose analgesic rebound headache by taking a good history.
  • Drug abuse and headache. [Journal Article]
    Med Clin North Am. 1991 May; 75(3):717-32.Elkind AH
  • Substance abuse has been reported frequently in chronic headache patients. The problem exists in most Western countries. Abuse of various compounds frequently leads to a state of dependency. Prescription as well as over-the-counter agents are often abused. Aspirin, acetaminophen, and caffeine are the most frequently abused compounds. Butalbital, ergot alkaloids, NSAIDS, and narcotic and oral or i…
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