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66 results
  • Drug Repurposing for Paracoccidioidomycosis Through a Computational Chemogenomics Framework. [Journal Article]
    Front Microbiol 2019; 10:1301de Oliveira AA, Neves BJ, … Pereira M
  • Paracoccidioidomycosis (PCM) is the most prevalent endemic mycosis in Latin America. The disease is caused by fungi of the genus Paracoccidioides and mainly affects low-income rural workers after inhalation of fungal conidia suspended in the air. The current arsenal of chemotherapeutic agents requires long-term administration protocols. In addition, chemotherapy is related to a significantly incr…
  • Identification of FDA-Approved Drugs with Activity against Stationary Phase Bartonella henselae. [Journal Article]
    Antibiotics (Basel) 2019; 8(2)Li T, Feng J, … Zhang Y
  • Bartonella henselae can cause various infections in humans, ranging from benign and self-limiting diseases to severe and life-threatening diseases as well as persistent infections that are difficult to treat. To develop more effective treatments for persistent Bartonella infections, in this study, we performed a high-throughput screen of an FDA-approved drug library against stationary phase B. he…
  • Drugs and Lactation Database (LactMed): Butoconazole [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • Vaginal butoconazole has not been studied during breastfeeding. About 5.5% of a vaginal dose is absorbed and its plasma half-life is 21 to 24 hours. Because there is no published experience with butoconazole during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.
    Acta Pol Pharm 2017; 74(3):777-784Podolska M, Bialecka W, … Mazurek A
  • The aim of this study was to test separation possibility of enantiomers of nine active substances belonging to imidazole derivatives: bifonazole, butoconazole, econazole, enilconazole, fenticonazole, isoconazole, miconazole, sertaconazole and tioconazole. The study was performed using HPLC method and the CHI- RALCEL OJ column (10 gm; 250 x 4.6 mm), the mobile phase flow rate of 0.8 mL/min and det…
  • Analysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbent. [Journal Article]
    J Enzyme Inhib Med Chem 2017; 32(1):1-11Campestre C, Locatelli M, … Carradori S
  • This paper reports the MEPS-HPLC-DAD method for the simultaneous determination of 12 azole drugs (bifonazole, butoconazole, clotrimazole, econazole, itraconazole, ketoconazole, miconazole, posaconazole, ravuconazole, terconazole, tioconazole and voriconazole) administered to treat different systemic and topical fungal infections, in biological samples. Azole drugs separation was performed in 36 m…
  • Inhibition of 11β-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. [Journal Article]
    Biochem Pharmacol 2017; 130:93-103Beck KR, Bächler M, … Odermatt A
  • Impaired 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2)-dependent cortisol inactivation can lead to electrolyte dysbalance, hypertension and cardiometabolic disease. Furthermore, placental 11β-HSD2 essentially protects the fetus from high maternal glucocorticoid levels, and its impaired function has been associated with altered fetal growth and a higher risk for cardio-metabolic diseases in l…
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