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265 results
  • Hepatobiliary Events in Migraine Therapy with Herbs-The Case of Petadolex, A Petasites Hybridus Extract. [Journal Article]
    J Clin Med 2019; 8(5)Anderson N, Borlak J
  • Petadolex®, a defined butterbur extract has clinically proven efficacy against migraine attacks. However, spontaneous reports indicate cases of herbal induced liver injury (HILI). While most HILI patients presented mild serum biochemistry changes (<3 ULN, dose range 50 to 225 mg/day; treatment duration 4-730 days) nine developed severe HILI (average time-to-onset 103 days, ALT-range 3-153; AST 2-…
  • New otonecine-type pyrrolizidine alkaloid from Petasites japonicus. [Journal Article]
    J Nat Med 2019; 73(3):602-607Kitajima M, Okabe K, … Takayama H
  • One new otonecine-type pyrrolizidine alkaloid secopetasitenine (1), along with petasitenine (fukinotoxine, 2), neopetasitenine (3), and senkirkine (4), was isolated from the whole plant of Petasites japonicus. The structure of 1 was determined by spectroscopic analyses and chemical conversion from the known alkaloid petasitenine (2).
  • StatPearls: Butterbur [BOOK]
    StatPearls Publishing: Treasure Island (FL) Din Lennox L California Northstate University Lui Forshing F CA Northstate Uni, College of Med BOOK
  • FDA approved indications:
  • TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal. [Journal Article]
    J Cell Mol Med 2019; 23(3):1976-1986Li Puma S, Landini L, … De Logu F
  • Safranal, contained in Crocus sativus L., exerts anti-inflammatory and analgesic effects. However, the underlying mechanisms for such effects are poorly understood. We explored whether safranal targets the transient receptor potential ankyrin 1 (TRPA1) channel, which in nociceptors mediates pain signals. Safranal by binding to specific cysteine/lysine residues, stimulates TRPA1, but not the TRP v…
  • Phytomedicines in the Treatment of Migraine. [Journal Article]
    CNS Drugs 2019; 33(5):399-415Rajapakse T, Davenport WJ
  • Migraine is a disabling neurovascular disorder with few targeted, tolerable and effective treatments. Phytomedicines, or plant-based medicinal formulations, hold great promise in the identification of novel therapeutic targets in migraine. Many patients also turn toward herbal and plant-based therapies for the treatment of their migraines as clinical and preclinical evidence of efficacy increases…
  • Migraine Headache Prophylaxis. [Journal Article]
    Am Fam Physician 2019; 99(1):17-24Ha H, Gonzalez A
  • Migraines impose significant health and financial burdens. Approximately 38% of patients with episodic migraines would benefit from preventive therapy, but less than 13% take prophylactic medications. Preventive medication therapy reduces migraine frequency, severity, and headache-related distress. Preventive therapy may also improve quality of life and prevent the progression to chronic migraine…
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