- A Multicentre, Open label, Randomized, Comparative, Parallel Group, Active-controlled, Phase III Clinical Trial to Evaluate Safety and Efficacy of Arbekacin Sulphate Injection versus Vancomycin Injection in Patients Diagnosed with MRSA Infection. [Journal Article]
- JAJ Assoc Physicians India 2018; 66(12):47-50
- CONCLUSIONS: Arbekacin can be considered as safe and effective alternative to vancomycin in the management of MRSA infections.
- Comparison of automated quantification and semiquantitative visual analysis findings of IQ SPECT MPI with conventional coronary angiography in patients with stable angina. [Journal Article]
- TKTurk Kardiyol Dern Ars 2019; 47(5):357-364
- CONCLUSIONS: The quantitative analysis and summed stress scores produced by the IQ SPECT system appear to be a useful and valid method to detect significant CAD.
- Treatment-Emergent Influenza Variant Viruses With Reduced Baloxavir Susceptibility: Impact on Clinical and Virologic Outcomes in Uncomplicated Influenza. [Journal Article]
- JIJ Infect Dis 2019 Jul 16
- CONCLUSIONS: The emergence of viruses with PA/I38X substitutions following baloxavir treatment was associated with transient rises in infectious virus titers, prolongation of virus detectability, initial delay in symptom alleviation, and uncommonly with symptom rebound. The potential transmissibility of PA/I38X-substituted viruses requires careful study.
- The Long-term Efficacy of Sodium Glucose Co-transporter 2 Inhibitor in Patients with Non-alcoholic Fatty Liver Disease. [Journal Article]
- IMIntern Med 2019; 58(14):1987-1992
- Objective Sodium glucose co-transporter 2 inhibitor (SGLT-2i), recommended for patients with type 2 diabetes, has been reported to improve the liver function test results in non-alcoholic fatty liver…
Objective Sodium glucose co-transporter 2 inhibitor (SGLT-2i), recommended for patients with type 2 diabetes, has been reported to improve the liver function test results in non-alcoholic fatty liver disease (NAFLD). However, the long-term effects of SGLT-2i on the liver function and body weight in NAFLD patients have not been fully elucidated. In this study, we investigated the long-term effects of SGLT-2i in NAFLD patients. Methods Twenty-two diabetic patients with NAFLD were enrolled in this study. We assessed the body weight, liver enzyme levels, metabolism, and glucose levels at 12 months (22 cases) and 24 months (15 cases) after the initiation of SGLT-2i. The changes in controlled attenuation parameter (CAP) and liver stiffness in 20 of the 22 patients were evaluated using transient elastography (TE) and acoustic radiation force impulse (ARFI) elastography before the initiation of treatment and 1 year later. Results Body weight and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were significantly decreased at 12 and 24 months after SGLT-2i treatment. The decrease in the levels of ALT at 12 and 24 months was significantly correlated with the level of ALT at the initiation of SGLT-2i (r=0.813, p=0.001 and r=0.867, p=0.0001, respectively). SGLT-2i also reduced the CAP and velocity of shear wave (Vs) values at 12 months (CAP 315.1±43.4 db/mL→293.1±27.2 db/mL, p=0.027; Vs 1.87±0.8 m/s→ 1.48±0.6 m/s, p=0.011). Conclusion SGLT-2i treatment improved the liver function test results and reduced the body weight in NAFLD patients over a period of 12-24 months. This improvement was greater in patients with higher ALT values at baseline than in those with lower values.
- Sleep microstructure in Parkinson's disease: cycling alternating pattern (CAP) as a sensitive marker of early NREM sleep instability. [Journal Article]
- SMSleep Med 2019 Apr 20
- CONCLUSIONS: The main result of our study consists in the disclosure of altered NREM sleep microstructure in PD even at an early stage of the disease, suggesting an early alteration of the central pathways involved in the NREM sleep building-up and stability.
- Early experience with cap-assisted endoscopic pancreatic necrosectomy: A technique to enhance safe tissue extraction and decrease interventions. [Case Reports]
- EIEndosc Int Open 2019; 7(7):E912-E915
- Background and study aim Endoscopic treatment of walled-off pancreatic necrosis (WOPN) has been established as an alternative to operative intervention for well selected patients for many years. Pati…
Background and study aim Endoscopic treatment of walled-off pancreatic necrosis (WOPN) has been established as an alternative to operative intervention for well selected patients for many years. Patients and methods A retrospective database of patients who underwent cap-assisted endoscopic necrosectomy of symptomatic or infected WOPN using the assistance of a sterilized banding cap was constructed. All procedures were performed at a single center between January 2017 and June 2018. Results Eight patients met the inclusion criteria for this study. Contrast computed tomography scan was obtained between the initial percutaneous or trans-gastric access and initial necrosectomy. The WOPN had a median length of 9.5 cm (range 3.2 - 14) and width of 5.3 cm (range 2.8 - 11.6). Median duration of endoscopic debridement was 69 minutes (range 21 - 105). Four of six patients underwent a second debridement with a median duration of 95 minutes (range 16 - 108). No periprocedural adverse events occurred. Follow-up was at 6 months, and there were no additional endoscopic or percutaneous interventions for recurrent pancreatic fluid collections. Conclusion The technique of cap-assisted necrosectomy can allow for safe and efficient method of endoscopically treating WOPN.
- Predicting the need for ICU admission in community-acquired pneumonia. [Journal Article]
- RMRespir Med 2019 Jul 08; 155:61-65
- CONCLUSIONS: Assigning differential weights to clinical predictive variables generated a score with accuracy that outperformed the original 2007 IDSA/ATS criteria for severe CAP and ICU admission.
- Combining morphological and biomechanical factors for optimal carotid plaque progression prediction: An MRI-based follow-up study using 3D thin-layer models. [Journal Article]
- IJInt J Cardiol 2019 Jul 04
- Plaque progression prediction is of fundamental significance to cardiovascular research and disease diagnosis, prevention, and treatment. Magnetic resonance image (MRI) data of carotid atheroscleroti…
Plaque progression prediction is of fundamental significance to cardiovascular research and disease diagnosis, prevention, and treatment. Magnetic resonance image (MRI) data of carotid atherosclerotic plaques were acquired from 20 patients with consent obtained. 3D thin-layer models were constructed to calculate plaque stress and strain. Data for ten morphological and biomechanical risk factors were extracted for analysis. Wall thickness increase (WTI), plaque burden increase (PBI) and plaque area increase (PAI) were chosen as three measures for plaque progression. Generalized linear mixed models (GLMM) with 5-fold cross-validation strategy were used to calculate prediction accuracy and identify optimal predictor. The optimal predictor for PBI was the combination of lumen area (LA), plaque area (PA), lipid percent (LP), wall thickness (WT), maximum plaque wall stress (MPWS) and maximum plaque wall strain (MPWSn) with prediction accuracy = 1.4146 (area under the receiver operating characteristic curve (AUC) value is 0.7158), while PA, plaque burden (PB), WT, LP, minimum cap thickness, MPWS and MPWSn was the best for WTI (accuracy = 1.3140, AUC = 0.6552), and a combination of PA, PB, WT, MPWS, MPWSn and average plaque wall strain (APWSn) was the best for PAI with prediction accuracy = 1.3025 (AUC = 0.6657). The combinational predictors improved prediction accuracy by 9.95%, 4.01% and 1.96% over the best single predictors for PAI, PBI and WTI (AUC values improved by 9.78%, 9.45%, and 2.14%), respectively. This suggests that combining both morphological and biomechanical risk factors could lead to better patient screening strategies.
- Loss of MAP3K7 sensitizes prostate cancer cells to CDK1/2 inhibition and DNA damage by disrupting homologous recombination. [Journal Article]
- MCMol Cancer Res 2019 Jul 12
- The combined loss of CHD1 and MAP3K7 promotes aggressive prostate cancer (CaP) by unknown mechanisms. Because these genes are both lost genetically in CaP, they cannot be directly targeted. We applie…
The combined loss of CHD1 and MAP3K7 promotes aggressive prostate cancer (CaP) by unknown mechanisms. Because these genes are both lost genetically in CaP, they cannot be directly targeted. We applied an established computational systems pharmacology approach (TRAP) to identify altered signaling pathways, and associated druggable targets. We compared gene expression profiles of CaP with co-loss of CHD1 & MAP3K7 with CaP diploid for these genes using TCGA patient samples. This analysis prioritized druggable target genes that included CDK1 and CDK2. We validated that inhibitors of these druggable target genes, including the CDK1/ CDK2 inhibitor dinaciclib, had anti-proliferative and cytotoxic effects selectively on mouse prostate cells with knockdown of Chd1 and Map3k7. Dinaciclib had stronger effects on prostate cells with suppression of Map3k7 independent of Chd1 and also compared to cells without loss of Map3k7. Dinaciclib treatment reduced expression of homologous recombination (HR)-repair genes such as ATM, ATR, BRCA2, and RAD51, blocked BRCA1 phosphorylation, reduced RAD51 foci formation, and increased γH2AX foci selectively in prostate cells with suppression of Map3k7, thus inhibiting HR repair of chromosomal double strand breaks. Dinaciclib-induced HR disruption was also observed in human prostate cells with knockdown of MAP3K7. Co-treatment of dinaciclib with DNA damaging agents or PARP inhibitor resulted in a stronger cytotoxic effect on prostate cells with suppression of MAP3K7 compared to those without loss of MAP3K7, or to each single agent. Implications: These findings support that loss of MAP3K7 is a main contributing factor to drug response through disruption of homologous recombination in CaP.
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- Cultivation of a versatile manganese-oxidizing aerobic granular sludge for removal of organic micropollutants from wastewater. [Journal Article]
- STSci Total Environ 2019 Jul 02; 690:417-425
- Organic micropollutants (OMPs) are frequently detected in water and wastewater, and have attracted wide attention due to potential adverse effects on ecosystems and human health. In this work, mangan…
Organic micropollutants (OMPs) are frequently detected in water and wastewater, and have attracted wide attention due to potential adverse effects on ecosystems and human health. In this work, manganese-oxidizing aerobic granular sludge (Mn-AGS) was successfully cultivated and applied to remove OMPs from wastewater. Biogenic manganese (III,IV) oxides (bio-MnOx) were generated and accumulated to 22.0-28.3 mg Mn/g SS in the final sludge. Neither the addition of allochthonous manganese-oxidizing bacteria (MnOB; Pseudomonas putida MnB1) nor the reduction in hydraulic retention time (HRT) facilitated the cultivation of Mn-AGS. Batch experiments of OMPs degradation indicated that Mn-AGS significantly improved (1.3-3.9 times) degradation rates of most OMPs. Removal rates of bisphenol A (BPA), 17α‑ethinylestradiol (EE2), tetracycline (TC), and chloramphenicol (CAP) were 3.0-12.6 μg/h/g SS by the traditional AGS and 8.0-16.3 μg/h/g SS by Mn-AGS; those of imazethapyr (IM) were relatively high, 64.7 ± 0.1 and 127.8 ± 2.5 μg/h/g SS by AGS and Mn-AGS, respectively. However, degradation of dichlorophenyl phosphine (DCPP) was slower by Mn-AGS than AGS, 9.0 ± 0.4 vs. 21.2 ± 0.9 μg/h/g SS, possibly due to inhibition of microbial activity by bio-MnOx. This work provides a promising method for treating OMPs in organic wastewater, but the possible inhibition of microbes by bio-MnOx should be noted.