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19,137 results
  • Structural insight into the carboxylesterase BioH from Klebsiella pneumoniae. [Journal Article]
    Biochem Biophys Res Commun 2019Wang L, Chen Y, … Xu Y
  • The BioH carboxylesterase which is a typical α/β-hydrolase enzyme involved in biotin synthetic pathway in most bacteria. BioH acts as a gatekeeper and blocks the further elongation of its substrate. In the pathogen Klebsiella pneumoniae, BioH plays a critical role in the biosynthesis of biotin. To better understand the molecular function of BioH, we determined the crystal structure of BioH from K…
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