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521 results
  • The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation. [Journal Article]
    Virchows Arch. 2020 Jun 30 [Online ahead of print]Bösmüller H, Traxler S, … Fend F
  • The pandemia of coronavirus disease 2019 (COVID-19) has caused more than 355,000 confirmed deaths worldwide. However, publications on postmortem findings are scarce. We present the pulmonary findings in four cases of fatal COVID-19 with a spectrum of lung pathology reflecting disease course and duration, invasive therapies, and laboratory features. Early disease is characterized by neutrophilic, …
  • Giant Cell Hepatitis - A Rare Association with Connective Tissue Disease. [Case Reports]
    Mediterr J Rheumatol. 2019 Dec; 30(4):224-227.Rauf M, Sen S, … Nisar MK
  • A 68-year-old gentleman presented to hepatology department with asymptomatic year-long history of stably deranged liver function tests. His peak alkaline phosphatase (ALP), was 828 with alanine transaminase (ALT) of 141. Full liver workup was negative; hence, a liver biopsy was organised, which confirmed giant cell hepatitis (GCH). A computed tomography (CT) scan revealed non-specific interstitia…
  • A cross-sectional analysis of clinicopathologic similarities and differences between Henoch-Schönlein purpura nephritis and IgA nephropathy. [Journal Article]
    PLoS One. 2020; 15(4):e0232194.Sugiyama M, Wada Y, … Shibata T
  • CONCLUSIONS: Although assessing both-Gd-IgA1 alone was insufficient to distinguish between HSPN and IgAN, patients with HSPN showed considerable glomerular capillaritis with subendothelial IgA deposition and significant elevation of serum inflammatory cytokines. Furthermore, such glomerular subendothelial IgA deposition might not contain Gd-IgA1, and factors associated with Gd-IgA1 were inconsistent among these 2 diseases. Thus, developmental mechanisms for IgAN might not apply to HSPN completely, and these 2 diseases still have different aspects.
  • A case of unilateral linear capillaritis. [Journal Article]
    Pediatr Dermatol. 2020 Apr 02 [Online ahead of print]Rodriguez-Garijo N, Tomas-Velazquez A, … Espana A
  • Unilateral linear capillaritis is a rare variant of the pigmented purpuric dermatoses that can be misdiagnosed due to confusion with other cutaneous diseases that follow a linear distribution. We present the case of an 8-year-old boy with hyperpigmented patches linearly distributed on the right arm, initially diagnosed with segmental neurofibromatosis.
  • StatPearls: Renal Transplantation Rejection [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Naik Ruchi H. RH Vanderbilt University Medical Center Shawar Saed H. SH Vanderbilt University Medical Center BOOK
  • Kidney transplantation is the treatment of choice in patients with end-stage renal disease or severe chronic kidney disease as it improves the quality of life and has better survival advantages compared to dialysis. Various factors merit consideration to match the donor kidney with the recipient, as the donor kidney act as an alloantigen. In general, when transplanting tissue or cells from a gene…
  • The color of skin: purple diseases of the skin, nails, and mucosa. [Review]
    Clin Dermatol. 2019 Sep - Oct; 37(5):528-547.Steuer AB, Cohen JM
  • The color purple can be seen in several types of eruptions including inflammatory dermatoses like lichen planus, infectious dermatoses like ecthyma gangrenosum, neoplasms like Kaposi sarcoma, and vasculitis and vasculopathy. The current review focuses on the clinical appearance, pathophysiology, and treatment of several vasculitides and vasculopathies including capillaritis, cutaneous small-vesse…
  • Persistent dermatomal eruption on a leg. [Case Reports]
    Dermatol Online J. 2019 Oct 15; 25(10)Hoesly PM, Cappel MA, Sluzevich JC
  • Unilateral linear capillaritis (ULC) is a rare variant of pigmented purpuric dermatoses (PPD) that is characterized by a linear or pseudo-dermatomal eruption on a single extremity. Although clinically distinct from the other PPD, it shares histopathologic features with this group. Herein, we present a man in his 50s who presented with asymptomatic macules and scaly papules on the left lower extre…
  • Pathological interpretation of connective tissue disease-associated lung diseases. [Review]
    Yeungnam Univ J Med. 2019 01; 36(1):8-15.Kwon KY
  • Connective tissue diseases (CTDs) can affect all compartments of the lungs, including airways, alveoli, interstitium, vessels, and pleura. CTD-associated lung diseases (CTD-LDs) may present as diffuse lung disease or as focal lesions, and there is significant heterogeneity between the individual CTDs in their clinical and pathological manifestations. CTD-LDs may presage the clinical diagnosis a p…
  • Clinical Insights into Diffuse Alveolar Hemorrhage in Antiphospholipid Syndrome. [Review]
    Curr Rheumatol Rep. 2019 09 06; 21(10):56.Stoots SA, Lief L, Erkan D
  • Diffuse alveolar hemorrhage (DAH) is a rare but devastating manifestation of antiphospholipid syndrome (APS) patients with or without other systemic autoimmune diseases. Data regarding diagnosis and treatment are limited to case series. We review diagnostic and therapeutic strategies employed in APS patients with DAH and discuss our experience in managing these complex patients.
  • Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis. [Case Reports]
    Intern Med. 2019 Oct 15; 58(20):3013-3017.Nemoto M, Nishioka K, … Aoshima M
  • Hepatitis B virus (HBV) is one of the main causes of polyarteritis nodosa (PAN). We herein report a rare case of HBV-associated vasculitis presenting with multiple pulmonary nodules, mimicking granulomatous polyangiitis (GPA), with no abnormalities of the ear, nose, or kidney. A surgical lung biopsy revealed geographic necrosis surrounded by palisading granuloma and capillaritis. Because the HBV …
  • Acute pulmonary embolism in a child with ANCA-negative Idiopathic Pulmonary Capillaritis. [Case Reports]
    Saudi Med J. 2019 Jun; 40(6):610-613.Asseri AA, Zeng Y, Daines CL
  • Diffuse alveolar hemorrhage is an uncommon and often fatal condition in children that is characterized by distinct histopathological etiologies. Herein, we discuss the case of an 11-year-old girl who presented with acute worsening of hypoxia and left-sided chest pain. The patient had lung biopsy-proven idiopathic pulmonary capillaritis and was being treated with prednisolone every alternate day, …
  • Antibody-Negative Relapse of Goodpasture Syndrome with Pulmonary Hemorrhage. [Case Reports]
    Case Rep Med. 2019; 2019:2975131.Rohm CL, Acree S, … Lovett L
  • Goodpasture syndrome is a rare autoimmune disease comprising antiglomerular basement membrane (anti-GBM) crescentic glomerulonephritis and pulmonary capillaritis with circulating anti-GBM antibodies. Rarely, antibody-negative cases have been described. We report a young, African American adult woman admitted with flank pain and hematuria with laboratory testing and kidney biopsy demonstrating ant…
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